    <SEC-DOCUMENT>0001062822-24-000018-index.html : 20240326
    <SEC-HEADER>0001062822-24-000018.hdr.sgml : 20240326
    <ACCEPTANCE-DATETIME>20240326160520
    ACCESSION NUMBER:		0001062822-24-000018
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20231231
    FILED AS OF DATE:		20240326
    DATE AS OF CHANGE:		20240326
    EFFECTIVENESS DATE:		20240326

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
    		CENTRAL INDEX KEY:			0001062822
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				760474169
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-30111
    		FILM NUMBER:		24783516

    	BUSINESS ADDRESS:
    		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
    		STREET 2:		SUITE 1100
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381
    		BUSINESS PHONE:		2818633000

    	MAIL ADDRESS:
    		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
    		STREET 2:		SUITE 1100
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
    		DATE OF NAME CHANGE:	20070426

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
    		DATE OF NAME CHANGE:	20000126
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>annualreport-march2024.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: annualreport-march2024.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>