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Cash and Cash Equivalents and Investments
9 Months Ended
Sep. 30, 2024
Cash, Cash Equivalents, and Short-Term Investments [Abstract]  
Cash and Cash Equivalents and Investments Cash and Cash Equivalents and Investments
The fair value of cash and cash equivalents and investments held at September 30, 2024 and December 31, 2023 are as follows: 
 As of September 30, 2024
 Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value
 (in thousands)
Cash and cash equivalents$34,551 $— $— $34,551 
Securities maturing within one year:    
U.S. treasury securities188,577 279 — 188,856 
Corporate debt securities34,892 77 (7)34,962 
Total short-term investments$223,469 $356 $(7)$223,818 
Total cash and cash equivalents and investments$258,020 $356 $(7)$258,369 
 As of December 31, 2023
 Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value
  (in thousands) 
Cash and cash equivalents$22,465 $— $— $22,465 
Securities maturing within one year:    
U.S. treasury securities141,577 31 (12)141,596 
Corporate debt securities5,954 11 — 5,965 
Total short-term investments$147,531 $42 $(12)$147,561 
Total cash and cash equivalents and investments
$169,996 $42 $(12)$170,026 

As of September 30, 2024 and December 31, 2023, Lexicon’s investments in an unrealized loss position had an estimated fair value of $14.8 million and $58.5 million, respectively. There were no realized gains or losses during either of the nine month periods ended September 30, 2024 and 2023.