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Income Taxes - Schedule of Deferred Tax Assets (Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 316,034 | $ 288,264
Research and development tax credits | 34,243 | 30,002
Orphan drug credits | 24,524 | 24,524
Capitalized research and development | 38,688 | 37,357
Stock-based compensation | 4,327 | 6,965
Interest | 1,748 | 1,359
Other | 2,726 | 3,308
Total deferred tax assets | 422,290 | 391,779
Deferred tax liabilities: |  |
Other | (1,357) | (1,608)
Total deferred tax liabilities | (1,357) | (1,608)
Less: valuation allowance | (420,933) | (390,171)
Net deferred tax liabilities | $ 0 | $ 0

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