<SEC-DOCUMENT>0001062822-25-000025-index.html : 20250422
<SEC-HEADER>0001062822-25-000025.hdr.sgml : 20250422
<ACCEPTANCE-DATETIME>20250422071130
ACCESSION NUMBER:		0001062822-25-000025
CONFORMED SUBMISSION TYPE:	ARS
PUBLIC DOCUMENT COUNT:		22
CONFORMED PERIOD OF REPORT:	20241231
FILED AS OF DATE:		20250422
DATE AS OF CHANGE:		20250422
EFFECTIVENESS DATE:		20250422

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		ARS
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		25854951

	BUSINESS ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
		DATE OF NAME CHANGE:	20070426

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>ARS
<SEQUENCE>1
<FILENAME>a2024annualreport.htm
<DESCRIPTION>ARS
<TEXT>
Document 1 - file: a2024annualreport.htm
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>2 <FILENAME>a2024annualreport001.jpg <TEXT> Document 2 - file: a2024annualreport001.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>3 <FILENAME>a2024annualreport002.jpg <TEXT> Document 3 - file: a2024annualreport002.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>4 <FILENAME>a2024annualreport003.jpg <TEXT> Document 4 - file: a2024annualreport003.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>5 <FILENAME>a2024annualreport004.jpg <TEXT> Document 5 - file: a2024annualreport004.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>6 <FILENAME>a2024annualreport005.jpg <TEXT> Document 6 - file: a2024annualreport005.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>7 <FILENAME>a2024annualreport006.jpg <TEXT> Document 7 - file: a2024annualreport006.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>8 <FILENAME>a2024annualreport007.jpg <TEXT> Document 8 - file: a2024annualreport007.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>9 <FILENAME>a2024annualreport008.jpg <TEXT> Document 9 - file: a2024annualreport008.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>10 <FILENAME>a2024annualreport009.jpg <TEXT> Document 10 - file: a2024annualreport009.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>11 <FILENAME>a2024annualreport010.jpg <TEXT> Document 11 - file: a2024annualreport010.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>12 <FILENAME>a2024annualreport011.jpg <TEXT> Document 12 - file: a2024annualreport011.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>13 <FILENAME>a2024annualreport012.jpg <TEXT> Document 13 - file: a2024annualreport012.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>14 <FILENAME>a2024annualreport013.jpg <TEXT> Document 14 - file: a2024annualreport013.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>15 <FILENAME>a2024annualreport014.jpg <TEXT> Document 15 - file: a2024annualreport014.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>16 <FILENAME>a2024annualreport015.jpg <TEXT> Document 16 - file: a2024annualreport015.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>17 <FILENAME>a2024annualreport016.jpg <TEXT> Document 17 - file: a2024annualreport016.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>18 <FILENAME>a2024annualreport017.jpg <TEXT> Document 18 - file: a2024annualreport017.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>19 <FILENAME>a2024annualreport018.jpg <TEXT> Document 19 - file: a2024annualreport018.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>20 <FILENAME>a2024annualreport019.jpg <TEXT> Document 20 - file: a2024annualreport019.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>21 <FILENAME>a2024annualreport020.jpg <TEXT> Document 21 - file: a2024annualreport020.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>22 <FILENAME>a2024annualreport021.jpg <TEXT> Document 22 - file: a2024annualreport021.jpg
</DOCUMENT> </SEC-DOCUMENT>