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Segment Information | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment Information | Segment Information Lexicon operates as a single reportable segment, primarily focusing on the discovery, development and commercialization of pharmaceutical products for the treatment of human disease. Substantially all of the Company’s revenues have been derived from drug discovery alliances, target validation collaborations for the development and, in some cases, analysis of the physiological effects of genes altered in knockout mice, technology licenses, subscriptions to its databases, product sales, government grants and contracts and compound library sales, as well as from commercial sales of its approved drug product. The chief operating decision maker (“CODM”) is the Company’s chief executive officer (“CEO”). The CEO manages and allocates resources on a total company basis by assessing the overall level of resources available and how to best deploy these resources across research and development projects in line with the Company’s long-term company-wide strategic goals. The CEO evaluates single-segment consolidated financial information against budget for purposes of making operating decisions, planning and forecasting for future periods, and deciding the level of investment in the Company’s various operating activities and other capital allocation activities. The CODM assesses financial performance based on consolidated net income (loss) (as reported on the consolidated statement of comprehensive income (loss)). The CEO also uses consolidated cash and cash equivalents and short-term investments (which can be found on our Consolidated Balance Sheets) as a measure of segment assets for allocating resources. Summary of segment net income (loss), including segment expenses were as follows:
|  | Three Months Ended September 30, |  | Nine Months Ended September 30,
|  | 2025 |  | 2024 |  | 2025 |  | 2024
|  | (in thousands) |  | (in thousands)
Revenues: |  |  |  |  |  |  |  |
Net product revenue |  | $ | 1,008 |  |  | $ | 1,741 |  |  | $ | 3,592 |  |  | $ | 4,451 |
Licensing revenue |  | 13,154 |  |  | — |  |  | 40,698 |  |  | — |
Royalties and other revenue |  | 20 |  |  | 9 |  |  | 20 |  |  | 76 |
Total revenues |  | 14,182 |  |  | 1,750 |  |  | 44,310 |  |  | 4,527 |
Operating expenses: |  |  |  |  |  |  |  |
Cost of sales |  | 10 |  |  | 71 |  |  | 73 |  |  | 268 |
Research and development |  | 16,799 |  |  | 24,314 |  |  | 44,535 |  |  | 53,056 |
Sales and marketing |  | 1,149 |  |  | 27,822 |  |  | 5,057 |  |  | 79,484 |
General and administrative |  | 4,841 |  |  | 7,067 |  |  | 19,133 |  |  | 20,541 |
Other segment expense (1) (2) |  | 3,570 |  |  | 6,169 |  |  | 9,643 |  |  | 15,558 |
Total operating expenses |  | 26,369 |  |  | 65,443 |  |  | 78,441 |  |  | 168,907 |
Loss from operations |  | (12,187) |  |  | (63,693) |  |  | (34,131) |  |  | (164,380) |
Interest and other expense |  | (2,155) |  |  | (4,562) |  |  | (6,308) |  |  | (11,721) |
Interest income and other |  | 1,573 |  |  | 3,444 |  |  | 5,628 |  |  | 9,464 |
Net loss |  | $ | (12,769) |  |  | $ | (64,811) |  |  | $ | (34,811) |  |  | $ | (166,637) |
(1) For the three and nine months ended September 30, 2025 and 2024, other segment expense includes stock compensation of (i) $1.8 million, $1.5 million, $5.0 million, and $4.7 million, respectively, related to research and development personnel and (ii) $1.6 million, $0.8 million, $4.6 million, and $4.7 million, respectively, related to general and administrative personnel. For the three and nine months ended September 30, 2024, other segment expense primarily includes, among other items, stock compensation of $0.6 million and $2.6 million, respectively, related to sales and marketing personnel. (2) For the three and nine months ended September 30, 2025, other segment expense includes, among other items, severance costs of $0.1 million and $0.2 million, respectively, related to research and development personnel. For the three and nine months ended September 30, 2024, other segment expense includes, among other items, severance costs of (i) $2.5 million and $2.7 million, respectively, related to sales and marketing personnel and (ii) $0.9 million and $0.9 million, respectively, related to general and administrative personnel.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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