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Cash and Cash Equivalents, Restricted Cash and Investments | 9 Months Ended
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Sep. 30, 2025
Cash, Cash Equivalents, and Short-Term Investments [Abstract] |
Cash and Cash Equivalents, Restricted Cash and Investments | Cash and Cash Equivalents, Restricted Cash and Investments The fair value of cash and cash equivalents, restricted cash and investments held are as follows:
|  | As of September 30, 2025
|  | Amortized Cost |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
|  | (in thousands)
Cash and cash equivalents |  | $ | 49,656 |  |  | $ | — |  |  | $ | — |  |  | $ | 49,656 |
Restricted cash |  | 29,000 |  |  | — |  |  | — |  |  | 29,000 |
Total cash and cash equivalents and restricted cash |  | $ | 78,656 |  |  | $ | — |  |  | $ | — |  |  | $ | 78,656 |
Securities maturing within one year: |  |  |  |  |  |  |  |
U.S. treasury securities |  | 43,223 |  |  | 24 |  |  | — |  |  | 43,247 |
Corporate debt securities |  | 23,042 |  |  | 9 |  |  | (4) |  |  | 23,047 |
Total short-term investments |  | $ | 66,265 |  |  | $ | 33 |  |  | $ | (4) |  |  | $ | 66,294 |
Total cash and cash equivalents, restricted cash and short-term investments |  | $ | 144,921 |  |  | $ | 33 |  |  | $ | (4) |  |  | $ | 144,950 |
|  | As of December 31, 2024
|  | Amortized Cost |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
|  |  |  | (in thousands) |  |
Cash and cash equivalents |  | $ | 66,656 |  |  | $ | — |  |  | $ | — |  |  | $ | 66,656 |
Restricted cash |  | — |  |  | — |  |  | — |  |  | — |
Total cash and cash equivalents and restricted cash |  | $ | 66,656 |  |  | $ | — |  |  | $ | — |  |  | $ | 66,656 |
Securities maturing within one year: |  |  |  |  |  |  |  |
U.S. treasury securities |  | 127,884 |  |  | 106 |  |  | — |  |  | 127,990 |
Corporate debt securities |  | 43,299 |  |  | 30 |  |  | (18) |  |  | 43,311 |
Total short-term investments |  | $ | 171,183 |  |  | $ | 136 |  |  | $ | (18) |  |  | $ | 171,301 |
Total cash and cash equivalents, restricted cash and short-term investments |  | $ | 237,839 |  |  | $ | 136 |  |  | $ | (18) |  |  | $ | 237,957 |
As of September 30, 2025 and December 31, 2024, Lexicon’s investments in an unrealized loss position had an estimated fair value of $16.3 million and $12.9 million, respectively. There were no realized gains or losses during either of the nine month periods ended September 30, 2025 and 2024.

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- Definition The entire disclosure for cash and cash equivalent footnotes, which may include the types of deposits and money market instruments, applicable carrying amounts, restricted amounts and compensating balance arrangements. Cash and equivalents include: (1) currency on hand (2) demand deposits with banks or financial institutions (3) other kinds of accounts that have the general characteristics of demand deposits (4) short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Generally, only investments maturing within three months from the date of acquisition qualify. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(1)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 944 -SubTopic 210 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(2)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147478777/944-210-S99-1 + Details
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- References No definition available. + Details
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