<SEC-DOCUMENT>0001193125-26-037644.txt : 20260204
<SEC-HEADER>0001193125-26-037644.hdr.sgml : 20260204
<ACCEPTANCE-DATETIME>20260204162505
ACCESSION NUMBER:		0001193125-26-037644
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20260202
FILED AS OF DATE:		20260204
DATE AS OF CHANGE:		20260204

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DEBBANE RAYMOND
		CENTRAL INDEX KEY:			0001053890
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598600

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal Group S.A.
		CENTRAL INDEX KEY:			0001053906
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			N4

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598596

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		(352) 22.42.59-1

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL GROUP S A
		DATE OF NAME CHANGE:	19980128

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Westend S.A.
		CENTRAL INDEX KEY:			0001283968
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598595

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		3522242591

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

	FORMER NAME:	
		FORMER CONFORMED NAME:	WESTEND S.A.
		DATE OF NAME CHANGE:	20120816

	FORMER NAME:	
		FORMER CONFORMED NAME:	WESTEND SA
		DATE OF NAME CHANGE:	20040317

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International S.C.A.
		CENTRAL INDEX KEY:			0001218180
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598598

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SCA
		DATE OF NAME CHANGE:	20110531

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SA
		DATE OF NAME CHANGE:	20030210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal Participations S.a r.l.
		CENTRAL INDEX KEY:			0002048403
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598599

	BUSINESS ADDRESS:	
		STREET 1:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Stichting Administratiekantoor Westend
		CENTRAL INDEX KEY:			0001460840
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			XX

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598594

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		H.J.E. WENCKEBACHWEG 252
		CITY:			AMSTERDAM
		PROVINCE COUNTRY:   	P7
		ZIP:			1096 AS
		BUSINESS PHONE:		352-224-2591

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		H.J.E. WENCKEBACHWEG 252
		CITY:			AMSTERDAM
		PROVINCE COUNTRY:   	P7
		ZIP:			1096 AS

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International Management S.A.
		CENTRAL INDEX KEY:			0001522131
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598597

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Siren, L.L.C.
		CENTRAL INDEX KEY:			0002005245
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598601

	BUSINESS ADDRESS:	
		STREET 1:		10 QUAIL ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06831
		BUSINESS PHONE:		212-371-1717

	MAIL ADDRESS:	
		STREET 1:		THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Global Management, LLC
		CENTRAL INDEX KEY:			0002005369
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		26598602

	BUSINESS ADDRESS:	
		STREET 1:		THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-371-1717

	MAIL ADDRESS:	
		STREET 1:		THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
		DATE OF NAME CHANGE:	20070426

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>ownership.xml
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<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-02-02</periodOfReport>

    <issuer>
        <issuerCik>0001062822</issuerCik>
        <issuerName>LEXICON PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>LXRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002005369</rptOwnerCik>
            <rptOwnerName>Invus Global Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002005245</rptOwnerCik>
            <rptOwnerName>Siren, L.L.C.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THE INVUS GROUP, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>750 LEXINGTON AVENUE 30TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001053890</rptOwnerCik>
            <rptOwnerName>DEBBANE RAYMOND</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THE INVUS GROUP, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>750 LEXINGTON AVENUE 30TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002048403</rptOwnerCik>
            <rptOwnerName>Artal Participations S.a r.l.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218180</rptOwnerCik>
            <rptOwnerName>Artal International S.C.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001522131</rptOwnerCik>
            <rptOwnerName>Artal International Management S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001053906</rptOwnerCik>
            <rptOwnerName>Artal Group S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001283968</rptOwnerCik>
            <rptOwnerName>Westend S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460840</rptOwnerCik>
            <rptOwnerName>Stichting Administratiekantoor Westend</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>H.J.E. WENCKEBACHWEG 252</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>AMSTERDAM</rptOwnerCity>
            <rptOwnerState>P7</rptOwnerState>
            <rptOwnerZipCode>1096 AS</rptOwnerZipCode>
            <rptOwnerStateDescription>NETHERLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>false</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-02-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>18553846</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.30</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>154734327</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F9"/>
                    <footnoteId id="F15"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-02-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3846154</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.30</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7362368</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F5"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F15"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-02-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
                <footnoteId id="F2"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1538462</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.30</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1538462</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F6"/>
                    <footnoteId id="F11"/>
                    <footnoteId id="F15"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Series B Convertible Preferred Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-02-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
                <footnoteId id="F3"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>367145.12</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>65.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>367145.12</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F9"/>
                    <footnoteId id="F15"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>35402689</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
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                    <footnoteId id="F12"/>
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        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
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            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5451204</value>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
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                    <value>See Footnotes</value>
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        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
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                    <value>1385689</value>
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                <directOrIndirectOwnership>
                    <value>I</value>
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                    <value>See Footnotes</value>
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                    <footnoteId id="F15"/>
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    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">On January 29, 2026, Artal Participations S.a r.l. entered into a purchase agreement with the Issuer pursuant to which Artal Participations S.a r.l. agreed to purchase 22,400,000 shares of common stock par value $0.001 per share (the &quot;Common Stock&quot;) of the Issuer at a price of $1.30 per share (the &quot;Purchase Price&quot;). On January 30, 2026, Artal Participations S.a r.l. assigned its right to purchase from the Issuer 3,846,154 shares of Issuer Common Stock to Invus Public Equities, L.P., and Invus Public Equities, L.P. agreed to purchase directly from the Issuer 3,846,154 shares of Issuer Common Stock at the Purchase Price. The purchase closed on February 2, 2026.</footnote>
        <footnote id="F2">On February 2, 2026, Avicenna Life Sci Master Fund LP purchased 1,538,462 shares of Common Stock as part of the Issuer's underwritten public offering.</footnote>
        <footnote id="F3">On January 29, 2026, Artal Participations S.a r.l. entered into a preferred stock purchase agreement (the &quot;Preferred Purchase Agreement&quot;) with the Issuer pursuant to which Artal Participations S.a r.l. agreed to purchase 367,145.12 shares of Series B Convertible Preferred Stock, par value $0.01 per share (the &quot;Preferred Stock&quot;) of the Issuer at a price of $65.00 per share. The Preferred Purchase Agreement also provides Artal Participations S.a r.l. the right to purchase from the Issuer, up to an additional 94,854.88 shares of Preferred Stock at a price per share of $65.00. Each share of Preferred Stock will automatically convert into 50 shares of the Issuer's Common Stock upon receipt of shareholder approval and the satisfaction of certain other conditions; however, absent the satisfaction of such conditions, the shares are not convertible. The purchase closed on February 2, 2026.</footnote>
        <footnote id="F4">These securities are directly held by Artal Participations S.a r.l.</footnote>
        <footnote id="F5">These securities are directly held by Invus Public Equities, L.P.</footnote>
        <footnote id="F6">These securities are directly held by Avicenna Life Sci Master Fund LP</footnote>
        <footnote id="F7">These securities are directly held by Invus, L.P.</footnote>
        <footnote id="F8">These securities are directly held by Invus US Partners LLC</footnote>
        <footnote id="F9">The sole shareholder of Artal Participations S.a r.l. is Artal International S.C.A. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the &quot;Stichting&quot;). Mr. Amaury Wittouck is the sole member of the board of the Stichting.</footnote>
        <footnote id="F10">The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The managing member of Invus Public Equities Advisors, LLC is Invus Global Management, LLC. The managing member of Invus Global Management, LLC is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.</footnote>
        <footnote id="F11">The general partner of Avicenna Life Sci Master Fund LP is Avicenna Life Sci Master GP LLC. The managing member of Avicenna Life Sci Master GP LLC is Ulys, L.L.C. The managing member of Ulys, L.L.C. is Mr. Raymond Debbane.</footnote>
        <footnote id="F12">The general partner of Invus, L.P. is Invus Advisors, L.L.C. The managing member of Invus Advisors, L.L.C. is Invus Global Management, LLC. The managing member of Invus Global Management, LLC. is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.</footnote>
        <footnote id="F13">The managing member of Invus US Partners LLC is Ulys, L.L.C. The managing member of Ulys, L.L.C. is Mr. Raymond Debbane.</footnote>
        <footnote id="F14">These securities are directly held by Mr. Raymond Debbane.</footnote>
        <footnote id="F15">Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.</footnote>
    </footnotes>

    <remarks>For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.</remarks>

    <ownerSignature>
        <signatureName>See Exhibit 99.1</signatureName>
        <signatureDate>2026-02-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<DOCUMENT>
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<FILENAME>lxrx-ex99_1.htm
<DESCRIPTION>EX-99.1
<TEXT>
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