<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2020-08-04T17:33:17.1285969+00:00 -->
<!-- Version            : 5.0.1.476 -->
<!-- Package ID         : c3af145632e140799b6b19b3d49e45b6 -->
<!-- Copyright (c) 2020 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="srdx_MaximumLimit" name="MaximumLimit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="srdx_EmployeeContributions" name="EmployeeContributions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="srdx_EarningsLossPerShareLineItems" name="EarningsLossPerShareLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_EarningsLossPerShareTable" name="EarningsLossPerShareTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_AcceleratedShareRepurchaseProgramMember" name="AcceleratedShareRepurchaseProgramMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_RightOfUseAssetsAbstract" name="RightOfUseAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_OperatingLeaseLiabilitiesAbstract" name="OperatingLeaseLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_EmbolitechLLCMember" name="EmbolitechLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_ClinicalResearchOrganizationMember" name="ClinicalResearchOrganizationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_InnoCoreTechnologiesBVMember" name="InnoCoreTechnologiesBVMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_CROPassThroughExpensesMember" name="CROPassThroughExpensesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="srdx_LicenseAgreementCommencementYear" name="LicenseAgreementCommencementYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="srdx_AnnualMinimumPaymentsForLicense" name="AnnualMinimumPaymentsForLicense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="srdx_FiniteLivedIntangibleAssetsUsefulLifeEndDate" name="FiniteLivedIntangibleAssetsUsefulLifeEndDate" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="srdx_FutureMinimumAnnualLicenseMaintenanceFeePayable" name="FutureMinimumAnnualLicenseMaintenanceFeePayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="srdx_GrossContractualObligation" name="GrossContractualObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="srdx_AssetAcquisitionInstallmentPaymentBeginningPeriod" name="AssetAcquisitionInstallmentPaymentBeginningPeriod" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="srdx_AssetAcquisitionInstallmentPaymentEndingPeriod" name="AssetAcquisitionInstallmentPaymentEndingPeriod" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="srdx_AssetAcquisitionContingentPaymentsUponAchievementOfRegulatoryMilestones" name="AssetAcquisitionContingentPaymentsUponAchievementOfRegulatoryMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="srdx_AssetAcquisitionContingencyPeriodEndingYear" name="AssetAcquisitionContingencyPeriodEndingYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="srdx_AssetAcquisitionCurrentContingentPaymentsUponAchievementOfRegulatoryMilestones" name="AssetAcquisitionCurrentContingentPaymentsUponAchievementOfRegulatoryMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
</xsd:schema>
