<SEC-DOCUMENT>0001571049-16-010848.txt : 20160120
<SEC-HEADER>0001571049-16-010848.hdr.sgml : 20160120
<ACCEPTANCE-DATETIME>20160120162215
ACCESSION NUMBER:		0001571049-16-010848
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20160120
DATE AS OF CHANGE:		20160120

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Semler Scientific, Inc.
		CENTRAL INDEX KEY:			0001554859
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		IRS NUMBER:				261367393
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88028
		FILM NUMBER:		161351237

	BUSINESS ADDRESS:	
		STREET 1:		2330 N.W. EVERETT STREET
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97210
		BUSINESS PHONE:		408-627-4557

	MAIL ADDRESS:	
		STREET 1:		2330 N.W. EVERETT STREET
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97210

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Murphy-Chutorian Douglas
		CENTRAL INDEX KEY:			0001594342

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	MAIL ADDRESS:	
		STREET 1:		C/O SEMLER SCIENTIFIC, INC.
		STREET 2:		2330 NW EVERETT ST.
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97210
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>t1600132_13da.htm
<DESCRIPTION>AMENDMENT NO. 2 TO SCHEDULE 13D
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE 13D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Amendment No. 2)&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Under the Securities Exchange Act of 1934</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SEMLER SCIENTIFIC, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-top: black 0.5pt solid">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Common Stock, par value $0.001 per share</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-top: black 0.5pt solid">(Title of Class
of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>81684M 104</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-top: black 0.5pt solid">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Yvan-Claude Pierre, Esq.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Marianne C. Sarrazin, Esq.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Cooley LLP</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1114 Avenue of the Americas</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>New York, New York 10036-7798</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Telephone: (212) 479-6000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-top: black 0.5pt solid">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name, Address and Telephone Number of Person</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Authorized to Receive Notices and Communications)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>December 31, 2015</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-top: black 0.5pt solid">(Date of Event
Which Requires Filing of this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">If the
filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D,
and is filing this schedule because of &sect;&sect;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. </FONT><FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: right"><B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>Page
                                         <B>2 </B>of<B> 5</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: center"><B>SCHEDULE 13D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD COLSPAN="6" STYLE="vertical-align: top; border: Black 1pt solid; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>CUSIP No. 81684M 104</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.75pt; text-indent: 0.5in">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; border-top: black 1pt solid; border-bottom: black 1pt solid; padding-bottom: 10pt"></TD>
    </TR>
<TR>

    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>1</B></TD>
    <TD COLSPAN="3" STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">NAMES OF REPORTING PERSONS</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Douglas Murphy-Chutorian, M.D.</B></P></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>2</B></TD>
    <TD COLSPAN="3" STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 0"><FONT STYLE="font-size: 10pt">CHECK THE APPROPRIATE BOX
        IF A MEMBER OF A GROUP</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 0"><FONT STYLE="font-size: 10pt">(a)&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></P></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>3</B></TD>
    <TD COLSPAN="3" STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; padding-left: 6pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>4</B></TD>
    <TD COLSPAN="3" STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt">SOURCE OF FUNDS*</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt"><B>PF</B></P></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>5</B></TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; border: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; padding-left: 6pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-size: 10pt">&#9;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>6</B></TD>
    <TD COLSPAN="3" STYLE="border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 0">CITIZENSHIP OR PLACE OF ORGANIZATION</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 2.7pt; text-indent: 0in"><B>United States</B></P></TD></TR>
<TR>
    <TD COLSPAN="2" ROWSPAN="4" STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0; text-align: center"><B>NUMBER OF</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>SHARES</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>BENEFICIALLY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>OWNED BY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>EACH</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>REPORTING</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center"><B>WITH</B></P></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; padding-left: 10pt">&nbsp;&nbsp;<B>7</B></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 2.7pt">SOLE VOTING POWER</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>543,089 shares</B></P></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; padding-left: 10pt">&nbsp;&nbsp;<B>8</B></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">SHARED VOTING POWER</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>63,571 shares</B></P></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; padding-left: 10pt"><B>9</B></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 0">SOLE DISPOSITIVE POWER</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt"><B>543,089 shares</B></P></TD></TR>
<TR>
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; padding-left: 10pt"><B>10</B></TD>
    <TD STYLE="vertical-align: top; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt">SHARED DISPOSITIVE POWER</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt"><B>63,571 shares</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>11</B></TD>
    <TD COLSPAN="3" STYLE="border: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
        PERSON</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt"><B>606,660 shares</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>12</B></TD>
    <TD COLSPAN="3" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; padding-left: 6pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*</FONT><BR><FONT STYLE="font-size: 10pt"> <FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;&nbsp;<B>13</B></TD>
    <TD COLSPAN="3" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt"><B>10.7%*</B></P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 4.5pt; padding-bottom: 2.7pt; font-size: 10pt; text-align: left">&nbsp;&nbsp;<B>14</B></TD>
    <TD COLSPAN="3" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 2.7pt">TYPE OF REPORTING PERSON*</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 2.7pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 4.5pt 0 2.7pt"><B>IN</B></P></TD></TR>
<TR>
    <TD STYLE="width: 42px">&nbsp;</TD>
    <TD STYLE="width: 63px">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

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<TD STYLE="width: 15pt; text-align: left">*</TD><TD STYLE="width: 5pt"></TD><TD STYLE="text-align: justify">Based upon an aggregate of 5,123,568 shares of the Issuer&rsquo;s (as defined below) common
                                                                            stock outstanding as of January 1, 2016.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: right"><B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>Page
                                         <B>3 </B>of<B> 5</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: right"><B>&nbsp;</B></P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-bottom: 10pt; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item&nbsp;1.</B></FONT></TD>
    <TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Security and Issuer </B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The equity securities covered by
this Schedule 13D (Amendment No. 2) are shares of common stock, $0.001 par value, of Semler Scientific, Inc., a Delaware
corporation (the &ldquo;Issuer&rdquo;). The Issuer&rsquo;s principal executive offices are located at 2330 NW Everett St.,
Portland, OR 97210.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-bottom: 10pt; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item&nbsp;2.</B></FONT></TD>
    <TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Identity and Background </B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">This statement is filed by Douglas Murphy-Chutorian,
M.D., a U.S. citizen (the &ldquo;Reporting Person&rdquo;). The Reporting Person&rsquo;s business address is the same as that of
the Issuer, 2330 NW Everett St., Portland, OR 97210, and his present principal occupation is serving as Chief Executive Officer
and a Director of the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Reporting Person has not, during the last
five years, (a) been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors) or (b) been party
to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or
is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject
to, federal or state securities laws or finding any violation with respect to such laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-bottom: 10pt; text-align: justify"><B>Item&nbsp;3.</B></TD><TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><B>Source and Amount of Funds or Other Consideration</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The information contained in Item 4 is incorporated
by reference into this Item 3.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"><TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-bottom: 10pt; text-align: justify"><B>Item&nbsp;4.</B></TD><TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><B>Purpose of Transaction.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Reporting Person acquired
an aggregate of 53,571 shares of the Issuer&rsquo;s common stock upon the closing of the Issuer&rsquo;s initial public
offering (&ldquo;IPO&rdquo;) on the same terms and for the same price as other investors in the Issuer&rsquo;s IPO. Such
shares were acquired by the Reporting Person&rsquo;s family trust, the Murphy-Chutorian Family Trust, of which he is
co-Trustee with his spouse, at the IPO price of $7.00 per share using personal funds (approximately $374,997). Such shares,
when aggregated with other acquisitions of the Issuer&rsquo;s equity securities by the Reporting Person in the 12 months
preceding the IPO exceeded 2% of the Issuer&rsquo;s outstanding common stock after closing of the IPO.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">The Reporting Person acquired an aggregate of 10,000 shares of the
Issuer&rsquo;s common stock in a series of open market purchases as follows: (i) April 30, 2014, 2,000 shares at $4.99 per share;
(ii) May 9, 2014, 1,400 shares at $4.01 per share; (iii) July 30, 2014, 1,000 shares at $3.40 per share; (iv) August 1, 2014, 1,500
shares at $3.50 per share; (v) November 4, 2014, 1,000 shares at $2.10 per share; November 5, 2014, 1,000 shares at $2.10 per share;
and November 7, 2014, 2,100 shares at $2.10 per share. Such shares were acquired by the Reporting Person&rsquo;s family trust,
the Murphy-Chutorian Family Trust, of which he is co-Trustee with his spouse, using an aggregate of $30,754 of personal funds.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">The Reporting Person has also received equity grants under the
Issuer&rsquo;s 2014 Stock Incentive Plan (the &ldquo;2014 Plan&rdquo;) as follows: (i) November 8, 2014 grant of options to acquire
85,000 shares of common stock at $2.10 per share, which options vest monthly over 4-years (1/48 per month) such that it is vested
in full on the four-year anniversary of the grant date; (ii) January 1, 2015 grant of options to acquire 75,000 shares of common
stock at $1.96 per share, which options vest monthly over 4-years (1/48 per month) such that it is vested in full on the four-year
anniversary of the grant date; (iii) July 21, 2015 grant of options that were contingent upon stockholder approval, which was
received October 29, 2015, to acquire 180,000 shares of common stock at $3.44 per share, which options originally vested monthly
over one-year (1/12 per month), but which are now, effective as of December 31, 2015, vested in full; and (iv) December 31, 2015
grant of fully-vested options to acquire 60,000 shares of common stock at $2.56 per share. In accordance with the terms
of the 2014 Plan, such options will expire 10-years after the grant date.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">On September 18, 2015, the Issuer and the Reporting Person agreed
to amend the terms of all his outstanding warrants to extend the maturity date to July 31, 2023.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Reporting Person consummated the transaction
described herein in order to acquire an interest in the Issuer for investment purposes. Depending upon future evaluations of the
business prospects of the Issuer and upon other developments, including, but not limited to, general economic and business conditions
and stock market conditions, the Reporting Person may purchase additional equity or other securities of the Issuer or dispose of
some or all of his holdings in the open market, in public offerings, in privately negotiated transactions or in other transactions,
or in any combination of the foregoing, subject to the Issuer&rsquo;s insider trading policy and relevant applicable securities
laws and regulations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Except as set forth in this Item 4, the Reporting
Person has no present plans or proposals that relate to, or that would result in, any of the actions specified in clauses (a) through
(j) of Item 4 of Schedule 13D.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="padding-bottom: 10pt; text-align: justify; width: 9%"><B>Item&nbsp;5.</B></TD><TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><B>Interest in Securities of the Issuer.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Reporting Person is the beneficial
owner of an aggregate of 606,660 shares of the Issuer&rsquo;s common stock (approximately 10.7% based on 5,123,568 shares
issued and outstanding on January 1, 2016). Other than the 63,571 shares of common stock held in the Reporting Person&rsquo;s
family trust, over which he shares voting and investment control with his spouse, the Reporting Person has sole voting and
investment control over such shares. Such beneficial ownership includes: (i) 63,571 shares of the Issuer&rsquo;s common stock
acquired as described in Item 4 (which shares are held in a family trust), (ii) options to purchase 20,000 shares of the
Issuer&rsquo;s common stock at $0.52 per share, which options (granted under the Issuer&rsquo;s 2007 equity compensation
plan) are fully vested and expire November 22, 2022, (iii) options to purchase 85,000 shares of the Issuer&rsquo;s common
stock at $2.10 per share, which options vest monthly over 4-years (1/48 per month) such that it is vested in full on the
four-year anniversary of the grant date, and which expire November 8, 2024; (iv) options to purchase 75,000 shares of common
stock at $1.96 per share, which options vest monthly over 4-years (1/48 per month) such that it is vested in full on the
four-year anniversary of the grant date, and which expire January 1, 2025; (v) options to purchase 180,000 shares of common
stock at $3.44 per share, which options are fully vested and expire October 28, 2025; (vi) options to purchase 60,000 shares
of common stock at $2.56 per share, which options are fully vested and expire December 30, 2025; (vii) warrants to purchase
25,000 shares of the Issuer&rsquo;s common stock at $2.00 per share, which warrants expire July 31, 2023; (viii) warrants to
purchase 16,875 shares of the Issuer&rsquo;s common stock at $4.00 per share, which warrants expire July 31, 2023; (ix)
warrants to purchase 155,432 shares of the Issuer&rsquo;s common stock at $4.50 per share, which warrants expire July 31,
2023; and (x) warrants to purchase 38,907 shares of the Issuer&rsquo;s common stock at $4.50 per share, which warrants
expire July 31, 2023.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Other than the December 31, 2015 grant of options to acquire 60,000
shares of common stock and acceleration of the July 21, 2015 grant of options as described in Item 4 of this Schedule 13D (Amendment
No. 2), the Reporting Person has not effected any transaction in the Issuer&rsquo;s common stock during the 60 days prior to the
date of this Schedule 13D (Amendment No. 2).</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: right"><B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>Page
                                         <B>4 </B>of<B> 5</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.7pt; text-align: right"><B>&nbsp;</B></P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="padding-bottom: 10pt; text-align: justify; width: 9%"><B>Item 6.</B></TD><TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><B>Contracts, Arrangements, Understandings or Relationships with Respect to Securities
of the Issuer.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 10pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 10pt; text-align: justify">As a stockholder of the Issuer prior
to its IPO, the Reporting Person is party to the following agreements:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 10pt; text-align: justify"><B><I>Investor Rights Agreement </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 10pt; text-align: justify">In June 2012, all the holders of the
Issuer&rsquo;s then outstanding common stock and convertible preferred stock, including the Reporting Person, entered into an Investor
Rights Agreement. This agreement currently provides for certain rights relating to the registration of the holders&rsquo; shares
of common stock, which rights will terminate five years following the completion of the IPO, or for any particular holder with
registration rights, at such time following the IPO when all securities held by that stockholder subject to registration rights
may be sold pursuant to Rule 144 under the Securities Act of 1933, as amended during any ninety (90) day period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 10pt; text-align: justify">Other than as described above, there
are no other contracts, arrangements, understandings, or relationships (legal or otherwise) between Reporting Person and any other
person with respect to the securities beneficially owned by the Reporting Person.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="padding-bottom: 10pt; text-align: justify; width: 9%"><B>Item 7.</B></TD><TD STYLE="padding-bottom: 10pt; text-align: justify; width: 91%"><B>Materials to be Filed as Exhibits</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 10pt 22.5pt; text-align: justify; text-indent: -22.5pt">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURE </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 9pt 0 0; text-indent: 24.5pt">After reasonable inquiry and to the best
of such Reporting Person&rsquo;s knowledge and belief, the undersigned certifies that the information set forth in this statement
is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 9pt 0 0">Dated: January 20, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 9pt 0 0 3.5in">&nbsp;</P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 50%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 46%">/s/ D<FONT STYLE="text-transform: lowercase">OUGLAS</FONT> M<FONT STYLE="text-transform: lowercase">URPHY</FONT>-C<FONT STYLE="text-transform: lowercase">HUTORIAN</FONT>,
    M.D.</TD>
</TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-top: #000000 1px solid">DOUGLAS MURPHY-CHUTORIAN, M.D.</TD>
</TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; margin-top: 0pt; margin-bottom: 6pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; margin-top: 0pt; margin-bottom: 6pt"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 9pt 0 0 3.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 9pt 0 0 3.5in">&nbsp;</P>





<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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