<SEC-DOCUMENT>0001949846-25-000668.txt : 20251209
<SEC-HEADER>0001949846-25-000668.hdr.sgml : 20251209
<ACCEPTANCE-DATETIME>20251209095147
ACCESSION NUMBER:		0001949846-25-000668
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251209
DATE AS OF CHANGE:		20251209

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Semler Scientific, Inc.
		CENTRAL INDEX KEY:			0001554859
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				261367393
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-36305
		FILM NUMBER:		251557840

	BUSINESS ADDRESS:	
		STREET 1:		51 E CAMPBELL AVE
		STREET 2:		SUITE 107-D
		CITY:			CAMPBELL
		STATE:			CA
		ZIP:			95008
		BUSINESS PHONE:		8777744211

	MAIL ADDRESS:	
		STREET 1:		51 E CAMPBELL AVE
		STREET 2:		SUITE 107-D
		CITY:			CAMPBELL
		STATE:			CA
		ZIP:			95008

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			William H.C. Chang & Diana Shon Chang TTEE Chang Family Trust U/A DTD 10/23/2006
		CENTRAL INDEX KEY:			0001742975
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144

	BUSINESS ADDRESS:	
		STREET 1:		C/O SEMLER SCIENTIFIC, INC.
		STREET 2:		911 BERN CT.
		CITY:			SAN JOSE
		STATE:			CA
		ZIP:			95112
		BUSINESS PHONE:		(877) 774-4211

	MAIL ADDRESS:	
		STREET 1:		C/O SEMLER SCIENTIFIC, INC.
		STREET 2:		911 BERN CT.
		CITY:			SAN JOSE
		STATE:			CA
		ZIP:			95112
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001742975</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001554859</issuerCik>
      <issuerName>Semler Scientific, Inc.</issuerName>
      <secFileNumber>001-36305</secFileNumber>
      <issuerAddress>
        <com:street1>51 E CAMPBELL AVE</com:street1>
        <com:street2>SUITE 107-D</com:street2>
        <com:city>CAMPBELL</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>95008</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8777744211</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>William H.C. Chang &amp; Diana Shon Chang TTEE Chang Family Trust U/A DTD 10/23/2006</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>100000</noOfUnitsSold>
      <aggregateMarketValue>1977000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>15159895</noOfUnitsOutstanding>
      <approxSaleDate>12/09/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>09/30/2012</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>55646</amountOfSecuritiesAcquired>
      <paymentDate>09/30/2012</paymentDate>
      <natureOfPayment>Cash/Check</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/02/2015</acquiredDate>
      <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>44354</amountOfSecuritiesAcquired>
      <paymentDate>03/02/2015</paymentDate>
      <natureOfPayment>Cash/Check</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Table 1 ) Date acquired 9/30/2012 - 7/1/2013 - Private Placement from issuer - 55,646 shares Table 1 ) Date acquired 3/2/2015 - 5/2/2017 - open market purchase - 44,354 shares</remarks>
    <noticeSignature>
      <noticeDate>12/09/2025</noticeDate>
      <signature>William Chang TTEE for Chang Family Trust 10/23/2006</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
