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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 RmByOFm2nzrfKOhLPpc5pQ==

<SEC-DOCUMENT>0000943440-10-000687.txt : 20101210
<SEC-HEADER>0000943440-10-000687.hdr.sgml : 20101210
<ACCEPTANCE-DATETIME>20101210130957
ACCESSION NUMBER:		0000943440-10-000687
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Securities Act Section 4(6)
FILED AS OF DATE:		20101210
DATE AS OF CHANGE:		20101210
EFFECTIVENESS DATE:		20101210

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lightwave Logic, Inc.
		CENTRAL INDEX KEY:			0001325964
		STANDARD INDUSTRIAL CLASSIFICATION:	MISCELLANEOUS PLASTIC PRODUCTS [3080]
		IRS NUMBER:				820497368
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-145927
		FILM NUMBER:		101244306

	BUSINESS ADDRESS:	
		STREET 1:		121 CONTINENTAL DRIVE
		STREET 2:		SUITE 110
		CITY:			NEWARK
		STATE:			DE
		ZIP:			19713
		BUSINESS PHONE:		(302) 356-2717

	MAIL ADDRESS:	
		STREET 1:		121 CONTINENTAL DRIVE
		STREET 2:		SUITE 110
		CITY:			NEWARK
		STATE:			DE
		ZIP:			19713

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THIRD-ORDER NANOTECHNOLOGIES INC
		DATE OF NAME CHANGE:	20070320

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THIRD-ORDER NANOTECHNOLOIES INC
		DATE OF NAME CHANGE:	20070222

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PSI TEC HOLDINGS INC
		DATE OF NAME CHANGE:	20050503
</SEC-HEADER>
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    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

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        <cik>0001325964</cik>
        <entityName>Lightwave Logic, Inc.</entityName>
        <issuerAddress>
            <street1>121 CONTINENTAL DRIVE</street1>
            <street2>SUITE 110</street2>
            <city>NEWARK</city>
            <stateOrCountry>DE</stateOrCountry>
            <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
            <zipCode>19713</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(302) 356-2717</issuerPhoneNumber>
        <jurisdictionOfInc>NEVADA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
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            <previousName>THIRD-ORDER NANOTECHNOLOGIES INC</previousName>
            <previousName>THIRD-ORDER NANOTECHNOLOIES INC</previousName>
            <previousName>PSI TEC HOLDINGS INC</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>S.</middleName>
                <lastName>Marcelli</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrew</firstName>
                <lastName>Ashton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Frederick</firstName>
                <lastName>Goetz, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Frederick</firstName>
                <lastName>Goetz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mary</firstName>
                <lastName>Goetz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Eaton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ross</firstName>
                <lastName>Fasick</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Pickett, III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            </relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Philips</firstName>
                <lastName>Smith</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Zelibor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 CONTINENTAL DRIVE</street1>
                <street2>SUITE 110</street2>
                <city>NEWARK</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Technology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>46</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000943440-10-000463</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-08-10</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>25000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1500000</totalOfferingAmount>
            <totalAmountSold>1500000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>28</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>261000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>Includes salaries for research and development</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Lightwave Logic, Inc.</issuerName>
                <signatureName>/s/ James S. Marcelli</signatureName>
                <nameOfSigner>James S. Marcelli</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2010-12-10</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
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-----END PRIVACY-ENHANCED MESSAGE-----
