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Discontinued operations (Details) - USD ($) |  | 12 Months Ended
--- | --- | ---
Aug. 01, 2016 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] |  |  |  |
Percentage of outstanding shares distributed | 100.00% |  |  |
Record date for distribution | Jul. 22, 2016 |  |  |
Number of shares received (in shares) | 1 |  |  |
Number of shares held (in shares) | 2 |  |  |
Number of common stock distributed (in shares) | 20,230,000 |  |  |
Term of manufacturing services contract |  | 10 years |  |
Term of transition services agreement |  | 2 years |  |
Assets [Abstract] |  |  |  |
Current assets of discontinued operations |  | $ 0 | $ 29,282,000 |
Non-current assets of discontinued operations |  | 0 | 76,365,000 |
Liabilities [Abstract] |  |  |  |
Current liabilities of discontinued operations |  | 0 | 17,348,000 |
Non-current liabilities of discontinued operations |  | 0 | 3,234,000 |
Aptevo [Member] |  |  |  |
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] |  |  |  |
Unsecured debt | $ 20,000,000 |  |  |
TSA revenue from Aptevo |  | 1,127,778 |  |
Manufacturing services revenue |  | 832,108 |  |
Revenues [Abstract] |  |  |  |
Product sales |  | 21,183,000 | 27,947,000 | $ 30,036,000
Contracts, grants and collaborations |  | 187,000 | 5,511,000 | 15,636,000
Total revenues |  | 21,370,000 | 33,458,000 | 45,672,000
Operating expense [Abstract] |  |  |  |
Cost of product sales |  | 11,556,000 | 16,809,000 | 16,449,000
Research and development |  | 18,024,000 | 34,811,000 | 46,108,000
Selling, general and administrative |  | 23,792,000 | 27,313,000 | 14,248,000
Income (loss) from operations |  | (32,002,000) | (45,475,000) | (31,133,000)
Other income (expense), net [Abstract] |  |  |  |
Other income (expense), net |  | (41,000) | (472,000) | 0
Income (loss) from discontinued operations before provision for (benefit from) income taxes |  | (32,043,000) | (45,947,000) | (31,133,000)
Provision for (benefit from) income taxes |  | (21,295,000) | (17,401,000) | (13,608,000)
Net Income (loss) from discontinued operations |  | (10,748,000) | (28,546,000) | (17,525,000)
Net Cash Provided by (Used in) Discontinued Operations [Abstract] |  |  |  |
Net cash (used in) provided by operating activities |  | (10,299,000) | (12,716,000) | (14,683,000)
Net cash provided by investing activities |  | (1,926,000) | (1,518,000) | (48,822,000)
Net cash provided by (used in) financing activities |  | 7,733,000 | 15,012,000 | 67,219,000
Net increase in cash and cash equivalents |  | $ (4,492,000) | 778,000 | $ 3,714,000
Aptevo [Member] | Disposed of by Sale [Member] |  |  |  |
Assets [Abstract] |  |  |  |
Cash and cash equivalents | 45,000,000 |  |  |
Accounts receivable, net | 4,465,000 |  |  |
Inventories | 11,959,000 |  |  |
Notes receivable | 20,000,000 |  |  |
Other current assets | 4,870,000 |  |  |
Current assets of discontinued operations | 86,294,000 |  |  |
Property, plant and equipment, net | 6,128,000 |  |  |
In-process research and development | 41,800,000 |  |  |
Intangible assets, net | 15,402,000 |  |  |
Goodwill | 13,902,000 |  |  |
Non-current assets of discontinued operations | 77,232,000 |  |  |
Total assets of discontinued operations | 163,526,000 |  |  |
Liabilities [Abstract] |  |  |  |
Accounts payable | 6,285,000 |  |  |
Accrued expenses and other current liabilities | 64,000 |  |  |
Accrued compensation | 2,456,000 |  |  |
Contingent consideration, current portion | 191,000 |  |  |
Provision for chargebacks | 2,341,000 |  |  |
Deferred revenue, current portion | 433,000 |  |  |
Current liabilities of discontinued operations | 11,770,000 |  |  |
Deferred revenue, net of current portion | 3,232,000 |  |  |
Other liabilities | 91,000 |  |  |
Non-current liabilities of discontinued operations | 3,323,000 |  |  |
Total liabilities of discontinued operations | $ 15,093,000 |  |  |
Aptevo [Member] | Held-for-sale [Member] |  |  |  |
Assets [Abstract] |  |  |  |
Cash and cash equivalents |  |  | 4,492,000 |
Accounts receivable, net |  |  | 6,861,000 |
Inventories |  |  | 16,049,000 |
Prepaid expenses and other current assets |  |  | 1,880,000 |
Current assets of discontinued operations |  |  | 29,282,000 |
Property, plant and equipment, net |  |  | 4,046,000 |
In-process research and development |  |  | 41,800,000 |
Intangible assets, net |  |  | 16,617,000 |
Goodwill |  |  | 13,902,000 |
Non-current assets of discontinued operations |  |  | 76,365,000 |
Total assets of discontinued operations |  |  | 105,647,000 |
Liabilities [Abstract] |  |  |  |
Accounts payable |  |  | 8,134,000 |
Accrued expenses and other current liabilities |  |  | 22,000 |
Accrued compensation |  |  | 2,684,000 |
Contingent consideration, current portion |  |  | 306,000 |
Provision for chargebacks |  |  | 2,238,000 |
Deferred revenue, current portion |  |  | 3,964,000 |
Current liabilities of discontinued operations |  |  | 17,348,000 |
Deferred revenue, net of current portion |  |  | 3,163,000 |
Other liabilities |  |  | 71,000 |
Non-current liabilities of discontinued operations |  |  | 3,234,000 |
Total liabilities of discontinued operations |  |  | $ 20,582,000 |

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