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Intangible assets, in-process research and development and goodwill (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Intangible Assets [Abstract] |  |  |  |
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) |  | $ 701 | $ 9,827 | $ 0
Finite-Lived Intangible Assets, Net |  | 33,865 |  | 33,865
Goodwill |  | 41,001 | 41,001 |
Cost Basis [Abstract] |  |  |  |
Intangible Assets, Beginning Balance |  | 57,099 |  |
Additions |  | 0 |  |
Intangible Assets, Ending Balance |  | 57,099 | 57,099 |
Accumulated Amortization [Abstract] |  |  |  |
Accumulated Amortization, Beginning Balance |  | (16,341) |  |
Amortization |  | 6,893 | 7,376 | 6,991
Accumulated Amortization, Ending balance |  | $ (23,234) | (16,341) |
Intangible assets, weighted average useful life |  | 75 months |  |
Net book value of intangible assets |  | $ 33,865 |  | 33,865
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract] |  |  |  |
2017 |  | 6,217 |  |
2018 |  | 6,217 |  |
2019 |  | 5,738 |  |
2020 |  | 5,657 |  |
2021 and beyond |  | 10,036 |  |
Finite-Lived Intangible Assets, Net |  | 33,865 |  | $ 33,865
Goodwill, Cost Basis [Abstract] |  |  |  |
Goodwill, Beginning Balance |  | 41,001 |  |
Goodwill, Additions |  | 0 |  |
Goodwill, Ending Balance |  | 41,001 | 41,001 |
In-process research and development assets |  | 0 | 701 |
EV-035 [Member] |  |  |  |
Intangible Assets [Abstract] |  |  |  |
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) | $ 9,800 |  |  |
Finite-Lived Intangible Assets, Net | 700 |  |  |
Accumulated Amortization [Abstract] |  |  |  |
Net book value of intangible assets | 700 |  |  |
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract] |  |  |  |
Finite-Lived Intangible Assets, Net | 700 |  |  |
Therapeutics and Vaccines [Member] |  |  |  |
Goodwill, Cost Basis [Abstract] |  |  |  |
Goodwill, Beginning Balance |  | 24,349 |  |
Goodwill, Additions |  | 0 |  |
Goodwill, Ending Balance |  | 24,349 | 24,349 |
Therapeutics and Vaccines [Member] | EV-035 [Member] |  |  |  |
Intangible Assets [Abstract] |  |  |  |
Goodwill | $ 22,000 |  |  |
Contract Manufacturing [Member] |  |  |  |
Goodwill, Cost Basis [Abstract] |  |  |  |
Goodwill, Beginning Balance |  | 6,736 |  |
Goodwill, Additions |  | 0 |  |
Goodwill, Ending Balance |  | 6,736 | 6,736 |
Medical Devices [Member] |  |  |  |
Goodwill, Cost Basis [Abstract] |  |  |  |
Goodwill, Beginning Balance |  | 9,916 |  |
Goodwill, Additions |  | 0 |  |
Goodwill, Ending Balance |  | $ 9,916 | $ 9,916 |

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