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Intangible assets, in-process research and development and goodwill (Tables)
12 Months Ended
Dec. 31, 2016
Intangible assets and in-process research and development [Abstract]  
Intangible Assets
Intangible assets consisted of the following:

    
(in thousands) 
 
Total
 
Cost basis
   
Balance at December 31, 2015
 
$
57,099
 
Additions
  
-
 
Balance at December 31, 2016
 
$
57,099
 
     
Accumulated amortization
    
Balance at December 31, 2015
 
$
(16,341
)
Amortization
  
(6,893
)
Balance at December 31, 2016
 
$
(23,234
)
     
Net book value at December 31, 2016
 
$
33,865
 

Future Amortization Expense
Future amortization expense as of December 31, 2016 is as follows:

(in thousands)
   
2017
 
$
6,217
 
2018
  
6,217
 
2019
  
5,738
 
2020
  
5,657
 
2021 and beyond
  
10,036
 
Total remaining amortization
 
$
33,865
 

Goodwill
The following table is a summary of changes in goodwill by reporting unit:

(in thousands) 
 
Therapeutics and vaccines
  
Contract manufacturing
  
Medical devices
  
Total
 
Cost Basis
            
Balance at December 31, 2015
 
$
24,349
  
$
6,736
  
$
9,916
  
$
41,001
 
Additions
  
-
   
-
   
-
   
-
 
Balance at December 31, 2016
 
$
24,349
  
$
6,736
  
$
9,916
  
$
41,001