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Stockholders' equity (Tables)
 12 Months Ended
Dec. 31, 2016
Stockholders' equity [Abstract]  
Option award activity
The following is a summary of option award activity under the Emergent Plans:

  
2006 Plan
  
2004 Plan
    
  
Number of Shares
  
Weighted-Average Exercise Price
  
Number of Shares
  
Weighted-Average Exercise Price
  
Aggregate Intrinsic Value
 
Outstanding at December 31, 2015
  
2,964,237
  
$
22.73
   
29,699
  
$
10.28
  
$
52,119,607
 
Granted
  
411,698
   
33.61
   
-
   
-
     
Exercised
  
(809,638
)
  
19.41
   
(29,699
)
  
10.28
     
Forfeited
  
(96,293
)
  
26.67
   
-
   
-
     
Cancelled
  
(146,986
)
  
28.33
   
-
   
-
     
Equitable adjustment
  
236,313
   
22.90
   
-
   
-
     
Outstanding at December 31, 2016
  
2,559,331
  
$
22.94
   
-
  
$
-
  
$
25,348,245
 
Exercisable at December 31, 2016
  
1,504,855
  
$
19.59
   
-
  
$
-
  
$
19,938,451
 
Options expected to vest at December 31, 2016
  
849,184
  
$
27.46
   
-
  
$
-
  
$
4,565,548
 
Restricted stock units activity
The following is a summary of restricted stock unit award activity under the 2006 Plan:

  
Number of Shares
  
Weighted-Average Grant Price
  
Aggregate Intrinsic Value
 
Outstanding at December 31, 2015
  
889,004
  
$
26.86
  
$
35,569,048
 
Granted
  
515,782
   
34.00
     
Vested
  
(420,599
)
  
24.68
     
Forfeited
  
(80,428
)
  
29.40
     
Cancelled
  
(107,514
)
  
30.90
     
Equitable adjustment
  
79,339
   
28.86
     
Outstanding at December 31, 2016
  
875,584
  
$
28.94
  
$
28,754,179
 
Allocated stock-based compensation expense
Stock-based compensation expense was recorded in the following financial statement line items:

  
Years ended December 31,
 
(in thousands)
 
2016
  
2015
  
2014
 
Cost of product sales
 
$
997
  
$
1,183
  
$
1,145
 
Research and development
  
2,297
   
2,324
   
2,779
 
Selling, general and administrative
  
14,062
   
11,234
   
7,830
 
Continuing operations
  
17,356
   
14,741
   
11,754
 
Discontinued operations
  
1,121
   
1,107
   
1,075
 
Total stock-based compensation expense
 
$
18,477
  
$
15,848
  
$
12,829