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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
Product sales $ 296,278 $ 328,969 $ 281,845
Contract manufacturing 49,138 42,968 30,944
Contracts and grants 143,366 117,394 91,677
Total revenues 488,782 489,331 404,466
Operating expenses:      
Cost of product sales and contract manufacturing 131,284 107,486 101,963
Research and development 108,290 119,186 104,721
Selling, general and administrative 143,686 121,145 108,594
Income from operations 105,522 141,514 89,188
Other income (expense):      
Interest income 1,053 572 320
Interest expense (7,617) (6,523) (8,240)
Other income (expense), net 263 153 2,926
Total other income (expense) (6,301) (5,798) (4,994)
Income from continuing operations before provision for income taxes 99,221 135,716 84,194
Provision for income taxes 36,697 44,300 29,928
Net Income from continuing operations 62,524 91,416 54,266
Loss from discontinued operations (net of tax) (10,748) (28,546) (17,525)
Net income $ 51,776 $ 62,870 $ 36,741
Net income per share - basic:      
Net income from continuing operations-basic $ 1.56 $ 2.37 $ 1.45
Net loss from discontinued operations-basic (0.27) (0.74) (0.47)
Net income per share - basic (in dollars per share) 1.29 1.63 0.98
Net income per share - diluted:      
Net income per share from continuing operations-diluted 1.35 2.02 1.26
Net loss per share from discontinued operations-diluted (0.22) (0.61) (0.38)
Net income per share-diluted $ 1.13 $ 1.41 $ 0.88
Weighted-average number of shares - basic (in shares) 40,184,159 38,595,435 37,344,891
Weighted-average number of shares - diluted (in shares) 49,335,112 47,255,842 45,802,807