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Discontinued operations (Details) - USD ($)
 12 Months Ended
Aug. 01, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]        
Percentage of outstanding shares distributed 100.00%      
Record date for distribution Jul. 22, 2016      
Number of shares received (in shares) 1      
Number of shares held (in shares) 2      
Number of common stock distributed (in shares) 20,230,000      
Term of manufacturing services contract   10 years    
Term of transition services agreement   2 years    
Assets [Abstract]        
Current assets of discontinued operations   $ 0 $ 29,282,000  
Non-current assets of discontinued operations   0 76,365,000  
Liabilities [Abstract]        
Current liabilities of discontinued operations   0 17,348,000  
Non-current liabilities of discontinued operations   0 3,234,000  
Aptevo [Member]        
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]        
Unsecured debt $ 20,000,000      
TSA revenue from Aptevo   1,127,778    
Manufacturing services revenue   832,108    
Revenues [Abstract]        
Product sales   21,183,000 27,947,000 $ 30,036,000
Contracts, grants and collaborations   187,000 5,511,000 15,636,000
Total revenues   21,370,000 33,458,000 45,672,000
Operating expense [Abstract]        
Cost of product sales   11,556,000 16,809,000 16,449,000
Research and development   18,024,000 34,811,000 46,108,000
Selling, general and administrative   23,792,000 27,313,000 14,248,000
Income (loss) from operations   (32,002,000) (45,475,000) (31,133,000)
Other income (expense), net [Abstract]        
Other income (expense), net   (41,000) (472,000) 0
Income (loss) from discontinued operations before provision for (benefit from) income taxes   (32,043,000) (45,947,000) (31,133,000)
Provision for (benefit from) income taxes   (21,295,000) (17,401,000) (13,608,000)
Net Income (loss) from discontinued operations   (10,748,000) (28,546,000) (17,525,000)
Net Cash Provided by (Used in) Discontinued Operations [Abstract]        
Net cash (used in) provided by operating activities   (10,299,000) (12,716,000) (14,683,000)
Net cash provided by investing activities   (1,926,000) (1,518,000) (48,822,000)
Net cash provided by (used in) financing activities   7,733,000 15,012,000 67,219,000
Net increase in cash and cash equivalents   $ (4,492,000) 778,000 $ 3,714,000
Aptevo [Member] | Disposed of by Sale [Member]        
Assets [Abstract]        
Cash and cash equivalents 45,000,000      
Accounts receivable, net 4,465,000      
Inventories 11,959,000      
Notes receivable 20,000,000      
Other current assets 4,870,000      
Current assets of discontinued operations 86,294,000      
Property, plant and equipment, net 6,128,000      
In-process research and development 41,800,000      
Intangible assets, net 15,402,000      
Goodwill 13,902,000      
Non-current assets of discontinued operations 77,232,000      
Total assets of discontinued operations 163,526,000      
Liabilities [Abstract]        
Accounts payable 6,285,000      
Accrued expenses and other current liabilities 64,000      
Accrued compensation 2,456,000      
Contingent consideration, current portion 191,000      
Provision for chargebacks 2,341,000      
Deferred revenue, current portion 433,000      
Current liabilities of discontinued operations 11,770,000      
Deferred revenue, net of current portion 3,232,000      
Other liabilities 91,000      
Non-current liabilities of discontinued operations 3,323,000      
Total liabilities of discontinued operations $ 15,093,000      
Aptevo [Member] | Held-for-sale [Member]        
Assets [Abstract]        
Cash and cash equivalents     4,492,000  
Accounts receivable, net     6,861,000  
Inventories     16,049,000  
Prepaid expenses and other current assets     1,880,000  
Current assets of discontinued operations     29,282,000  
Property, plant and equipment, net     4,046,000  
In-process research and development     41,800,000  
Intangible assets, net     16,617,000  
Goodwill     13,902,000  
Non-current assets of discontinued operations     76,365,000  
Total assets of discontinued operations     105,647,000  
Liabilities [Abstract]        
Accounts payable     8,134,000  
Accrued expenses and other current liabilities     22,000  
Accrued compensation     2,684,000  
Contingent consideration, current portion     306,000  
Provision for chargebacks     2,238,000  
Deferred revenue, current portion     3,964,000  
Current liabilities of discontinued operations     17,348,000  
Deferred revenue, net of current portion     3,163,000  
Other liabilities     71,000  
Non-current liabilities of discontinued operations     3,234,000  
Total liabilities of discontinued operations     $ 20,582,000