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Fair value measurements (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Liabilities [Abstract]    
Payment of contingent obligations  
Unobservable Input Reconciliation [Roll Forward]    
Balance, beginning of period $ 25,155 40,037
Expense (income) included in earnings (10,857) (10,884)
Settlements (1,113) (4,803)
Purchases, sales and issuances 0 805
Transfers in/(out) of Level 3 0 0
Balance, end of period 13,185 25,155
RSDL [Member]    
Liabilities [Abstract]    
Fair value adjustment for contingent obligations (5,400) (1,500)
Evolva Holding SA 035 & Unither [Member]    
Liabilities [Abstract]    
Fair value adjustment for contingent obligations (5,400) (9,400)
Unobservable Input Reconciliation [Roll Forward]    
Contingent value rights based on the novation of the contract   4,000
Fair Value, Measurements, Recurring [Member]    
Assets [Abstract]    
Investment in money market funds [1] 10 3,323
Total assets 10 3,323
Liabilities [Abstract]    
Contingent price consideration 13,185 25,155
Total liabilities 13,185 25,155
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]    
Assets [Abstract]    
Investment in money market funds [1] 10 3,323
Total assets 10 3,323
Liabilities [Abstract]    
Contingent price consideration 0 0
Total liabilities 0 0
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]    
Assets [Abstract]    
Investment in money market funds [1] 0 0
Total assets 0 0
Liabilities [Abstract]    
Contingent price consideration 0 0
Total liabilities 0 0
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]    
Assets [Abstract]    
Investment in money market funds [1] 0 0
Total assets 0 0
Liabilities [Abstract]    
Contingent price consideration 13,185 25,155
Total liabilities $ 13,185 $ 25,155
[1] Included in cash and cash equivalents in accompanying consolidated balance sheets.