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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities:      
Net income (loss) $ 51,776 $ 62,870 $ 36,741
Adjustments to reconcile to net cash provided by operating activities:      
Stock-based compensation expense 18,477 15,848 12,829
Other Depreciation and Amortization 38,229 35,335 32,453
Deferred income taxes 5,190 3,464 16,493
Change in fair value of contingent obligations (10,838) (10,599) 3,133
Write off of debt issuance costs 0 0 1,831
Impairment of in-process research and development 701 9,827 0
Impairment and abandonment of long-lived assets 5,569 1,147 0
Bad debt expense 0 3,481 0
Excess tax benefits from stock-based compensation (10,619) (11,281) (5,987)
Other 452 271 1,284
Changes in operating assets and liabilities:      
Accounts receivable (22,446) (64,351) 21,405
Inventories (9,026) (11,262) 4,229
Income taxes (4,560) (3,550) (4,711)
Prepaid expenses and other assets (2,089) 2,319 (8,472)
Accounts payable (14,791) 4,749 (9,279)
Accrued expenses and other liabilities 624 45 2,685
Accrued compensation 2,236 2,680 4,539
Provision for chargebacks 0 (8) 299
Deferred revenue 4,602 3,474 2,846
Net cash provided by operating activities 53,487 44,459 112,318
Cash flows from investing activities:      
Purchases of property, plant and equipment (76,257) (44,812) (30,673)
Acquisitions, net of acquired cash 0 (650) (179,379)
Net cash used in investing activities (76,257) (45,462) (210,052)
Cash flows from financing activities:      
Proceeds from convertible debenture, net of bank fees 0 0 241,588
Proceeds from borrowings on long-term indebtedness 0 2,000 1,000
Issuance of common stock subject to employee equity plans 17,125 25,961 14,078
Excess tax benefits from stock-based compensation 10,619 11,281 5,987
Principal payments on long-term indebtedness and line of credit 0 0 (62,000)
Distribution to Aptevo (45,000) 0 0
Contingent obligation payments (1,385) (5,693) (1,579)
Purchase of treasury stock 0 (100) (200)
Net cash (used in) provided by financing activities (18,641) 33,449 198,874
Effect of exchange rate changes on cash and cash equivalents 129 (150) 21
Net (decrease) increase in cash and cash equivalents (41,282) 32,296 101,161
Cash and cash equivalents at beginning of year 312,795 280,499 179,338
Cash and cash equivalents at end of year 271,513 312,795 280,499
Supplemental disclosure of cash flow information:      
Cash paid during the year for interest 8,210 7,751 3,761
Cash paid during the year for income taxes 10,081 28,271 4,711
Supplemental information on non-cash investing and financing activities:      
Purchases of property, plant and equipment unpaid at year end $ 13,459 $ 4,379 $ 5,394