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Stockholders' equity (Tables) | 12 Months Ended
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Dec. 31, 2017
Stockholders' equity [Abstract] |
Option award activity | The following is a summary of stock option award activity under the 2006 Plan:
|  | 2006 Plan |  |  |  |
|  | Number of Shares |  |  | Weighted-Average Exercise Price |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2016 |  |  | 2,559,331 |  |  | $ | 22.94 |  |  | $ | 25,348,245 |
Granted |  |  | 427,821 |  |  |  | 31.13 |  |  |  |  |
Exercised |  |  | (792,795 | ) |  |  | 19.95 |  |  |  |  |
Forfeited |  |  | (72,952 | ) |  |  | 29.30 |  |  |  |  |
Outstanding at December 31, 2017 |  |  | 2,121,405 |  |  | $ | 25.48 |  |  | $ | 44,518,585 |
Exercisable at December 31, 2017 |  |  | 1,307,330 |  |  | $ | 22.63 |  |  | $ | 31,170,967 |
Options expected to vest at December 31, 2017 |  |  | 632,954 |  |  | $ | 29.91 |  |  | $ | 10,480,716 |
Restricted stock units activity | The following is a summary of restricted stock unit award activity under the 2006 Plan:
|  | Number of Shares |  |  | Weighted-Average Grant Price |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2016 |  |  | 875,584 |  |  | $ | 28.94 |  |  | $ | 28,754,179 |
Granted |  |  | 480,959 |  |  |  | 31.49 |  |  |  |  |
Vested |  |  | (423,840 | ) |  |  | 30.52 |  |  |  |  |
Forfeited |  |  | (80,983 | ) |  |  | 29.21 |  |  |  |  |
Outstanding at December 31, 2017 |  |  | 851,720 |  |  | $ | 30.84 |  |  | $ | 39,579,428 |
Allocated stock-based compensation expense | Stock-based compensation expense was recorded in the following financial statement line items:
|  | Year Ended December 31, |
(in thousands) |  | 2017 |  |  | 2016 |  |  | 2015 |
Cost of product sales |  | $ | 1,076 |  |  | $ | 997 |  |  | $ | 1,183 |
Research and development |  |  | 2,526 |  |  |  | 2,297 |  |  |  | 2,324 |
Selling, general and administrative |  |  | 11,611 |  |  |  | 14,062 |  |  |  | 11,234 |
Continuing operations |  |  | 15,213 |  |  |  | 17,356 |  |  |  | 14,741 |
Discontinued operations |  |  | - |  |  |  | 1,121 |  |  |  | 1,107 |
Total stock-based compensation expense |  | $ | 15,213 |  |  | $ | 18,477 |  |  | $ | 15,848 |

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