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Stockholders' equity, Stock options and restricted stock units (Details) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2017 USD ($) Plan $ / shares shares | Dec. 31, 2016 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares | Jul. 14, 2016 USD ($)
Aggregate intrinsic value [Abstract] |  |  |  |
Weighted average period expected to be recognized related to unvested equity awards | 2 years |  |  |
Compensation cost expected to be recognized related to unvested equity awards | $ 17,900,000 |  |  |
Authorized amount for the repurchase program |  |  |  | $ 50,000,000
Repurchased common stock (in shares) | shares | 800,000 |  |  |
Repurchased common stock | $ 33,077,000 | $ 0 | $ 100,000 |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | 15,213,000 | 18,477,000 | 15,848,000 |
Continuing Operations [Member] |  |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | 15,213,000 | 17,356,000 | 14,741,000 |
Discontinued Operations [Member] |  |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 0 | $ 1,121,000 | $ 1,107,000 |
Stock Options [Member] |  |  |  |
Aggregate intrinsic value [Abstract] |  |  |  |
Weighted average remaining contractual term of options outstanding | 4 years | 4 years |  |
Weighted average remaining contractual term of options exercisable | 3 years 2 months 12 days | 3 years 2 months 12 days |  |
Weighted average grant date fair value of options granted (in dollars per share) | $ / shares | $ 10.53 | $ 9.24 | $ 8.66 |
Total intrinsic value of options exercised | $ 13,900,000 | $ 15,600,000 | $ 20,200,000 |
Total fair value of awards vested | $ 17,900,000 | $ 16,900,000 | 14,400,000 |
2006 Plan [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Number of equity award plans | Plan | 1 |  |  |
2006 Plan [Member] | Stock Options [Member] |  |  |  |
Options outstanding [Roll Forward] |  |  |  |
Outstanding, beginning of period (in shares) | shares | 2,559,331 |  |  |
Granted (in shares) | shares | 427,821 |  |  |
Exercised (in shares) | shares | (792,795) |  |  |
Forfeited (in shares) | shares | (72,952) |  |  |
Outstanding, end of period (in shares) | shares | 2,121,405 | 2,559,331 |  |
Exercisable, end of period (in shares) | shares | 1,307,330 |  |  |
Options expected to vest, end of period (in shares) | shares | 632,954 |  |  |
Weighted-Average Exercise Price [Roll Forward] |  |  |  |
Outstanding, beginning of period (in dollars per share) | $ / shares | $ 22.94 |  |  |
Granted (in dollars per share) | $ / shares | 31.13 |  |  |
Exercised (in dollars per share) | $ / shares | 19.95 |  |  |
Forfeited (in dollars per share) | $ / shares | 29.30 |  |  |
Outstanding, end of period (in dollars per share) | $ / shares | 25.48 | $ 22.94 |  |
Exercisable, end of period (in dollars per share) | $ / shares | 22.63 |  |  |
Options expected to vest, end of period (in dollars per share) | $ / shares | $ 29.91 |  |  |
Aggregate Intrinsic Value [Abstract] |  |  |  |
Outstanding, beginning of period | $ 25,348,245 |  |  |
Outstanding, end of period | 44,518,585 | $ 25,348,245 |  |
Exercisable, end of period | 31,170,967 |  |  |
Options expected to vest, end of period | $ 10,480,716 |  |  |
2006 Plan [Member] | Restricted Stock Units (RSUs) [Member] |  |  |  |
Restricted stock unit award activity [Roll Forward] |  |  |  |
Outstanding, beginning of period (in shares) | shares | 875,584 |  |  |
Granted (in shares) | shares | 480,959 |  |  |
Vested (in shares) | shares | (423,840) |  |  |
Forfeited (in shares) | shares | (80,983) |  |  |
Outstanding, end of period (in shares) | shares | 851,720 | 875,584 |  |
Weighted-Average Grant Price [Roll Forward] |  |  |  |
Outstanding, beginning of period (in dollars per share) | $ / shares | $ 28.94 |  |  |
Granted (in dollars per share) | $ / shares | 31.49 |  |  |
Vested (in dollars per share) | $ / shares | 30.52 |  |  |
Forfeited (in dollars per share) | $ / shares | 29.21 |  |  |
Outstanding, end of period (in dollars per share) | $ / shares | $ 30.84 | $ 28.94 |  |
Aggregate intrinsic value [Abstract] |  |  |  |
Outstanding, beginning of period | $ 28,754,179 |  |  |
Outstanding, end of period | $ 39,579,428 | $ 28,754,179 |  |
2004 Plan [Member] | Stock Options [Member] |  |  |  |
Options outstanding [Roll Forward] |  |  |  |
Options expected to vest, end of period (in shares) | shares | 0 |  |  |
Weighted-Average Exercise Price [Roll Forward] |  |  |  |
Options expected to vest, end of period (in dollars per share) | $ / shares | $ 0 |  |  |
Cost of Product Sales [Member] | Continuing Operations [Member] |  |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 1,076,000 | 997,000 | 1,183,000 |
Research and Development [Member] | Continuing Operations [Member] |  |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | 2,526,000 | 2,297,000 | 2,324,000 |
Selling, General and Administrative [Member] | Continuing Operations [Member] |  |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 11,611,000 | $ 14,062,000 | $ 11,234,000 |

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- Definition Weighted average fair value as of the grant date of equity-based award plans other than stock (unit) option plans that were not exercised or put into effect as a result of the occurrence of a terminating event. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average fair value of nonvested awards on equity-based plans excluding option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, revenue or profit achievement stock award plan) for which the employer is contingently obligated to issue equity instruments or transfer assets to an employee who has not yet satisfied service or performance criteria necessary to gain title to proceeds from the sale of the award or underlying shares or units. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average fair value as of grant date pertaining to an equity-based award plan other than a stock (or unit) option plan for which the grantee gained the right during the reporting period, by satisfying service and performance requirements, to receive or retain shares or units, other instruments, or cash in accordance with the terms of the arrangement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Number of options outstanding, including both vested and non-vested options. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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