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Intangible assets and goodwill (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cost Basis [Abstract] |  |  |
Intangible Assets, Beginning Balance | $ 57,099 |  |
Additions | 94,304 |  |
Intangible Assets, Ending Balance | 151,403 | $ 57,099 |
Accumulated Amortization [Abstract] |  |  |
Accumulated Amortization, Beginning Balance | (23,234) |  |
Amortization | 8,572 | 6,893 | $ 7,376
Accumulated Amortization, Ending balance | (31,806) | (23,234) |
Net book value of intangible assets | $ 119,597 |  |
Intangible assets, weighted average useful life | 105 months |  |
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract] |  |  |
2018 | $ 15,647 |  |
2019 | 15,168 |  |
2020 | 15,087 |  |
2021 | 13,596 |  |
2022 and beyond | 60,099 |  |
Net book value of intangible assets | 119,597 |  |
Goodwill, Cost Basis [Abstract] |  |  |
Goodwill, Beginning Balance | 41,001 |  |
Goodwill, Additions | 8,129 |  |
Goodwill, Ending Balance | 49,130 | 41,001 |
Therapeutics and Vaccines [Member] |  |  |
Goodwill, Cost Basis [Abstract] |  |  |
Goodwill, Beginning Balance | 24,349 |  |
Goodwill, Additions | 8,129 |  |
Goodwill, Ending Balance | 32,478 | 24,349 |
Contract Manufacturing [Member] |  |  |
Goodwill, Cost Basis [Abstract] |  |  |
Goodwill, Beginning Balance | 6,736 |  |
Goodwill, Additions | 0 |  |
Goodwill, Ending Balance | 6,736 | 6,736 |
Medical Devices [Member] |  |  |
Goodwill, Cost Basis [Abstract] |  |  |
Goodwill, Beginning Balance | 9,916 |  |
Goodwill, Additions | 0 |  |
Goodwill, Ending Balance | $ 9,916 | $ 9,916 |

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- Definition Amount of amortization expense expected to be recognized during the fifth fiscal year and after following the latest fiscal year for assets, excluding financial assets and goodwill, lacking physical substance with a finite life. + References No definition available. + Details
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- Definition Weighted average amortization period of finite-lived intangible assets acquired either individually or as part of a group of assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 1 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16265-109275 + Details
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- Definition The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16225-109274 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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- Definition Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the fourth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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- Definition Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the second fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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- Definition Amount before amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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- Definition Amount of increase in asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized resulting from a business combination. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=35741047&loc=d3e13816-109267 + Details
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