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Intangible assets and goodwill (Tables)
12 Months Ended
Dec. 31, 2017
Intangible assets and goodwill [Abstract]  
Intangible Assets
Intangible assets consisted of the following:

    
(in thousands) 
 
Total
 
Cost basis
   
Balance at December 31, 2016
 
$
57,099
 
Additions
  
94,304
 
Balance at December 31, 2017
 
$
151,403
 
     
Accumulated amortization
    
Balance at December 31, 2016
 
$
(23,234
)
Amortization
  
(8,572
)
Balance at December 31, 2017
 
$
(31,806
)
     
Net book value at December 31, 2017
 
$
119,597
 

Future Amortization Expense
Future amortization expense as of December 31, 2017 is as follows:

(in thousands)
   
2018
 
$
15,647
 
2019
  
15,168
 
2020
  
15,087
 
2021
  
13,596
 
2022 and beyond
  
60,099
 
Total remaining amortization
 
$
119,597
 

Goodwill
The following table is a summary of changes in goodwill by reporting unit:

(in thousands) 
 
Therapeutics and vaccines
  
Contract manufacturing
  
Devices
  
Total
 
Cost Basis
            
Balance at December 31, 2016
 
$
24,349
  
$
6,736
  
$
9,916
  
$
41,001
 
Additions
  
8,129
   
-
   
-
   
8,129
 
Balance at December 31, 2017
 
$
32,478
  
$
6,736
  
$
9,916
  
$
49,130