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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Product sales $ 421,516 $ 296,278 $ 328,969
Contract manufacturing 68,935 49,138 42,968
Contracts and grants 70,422 143,366 117,394
Total revenues 560,873 488,782 489,331
Operating expenses:      
Cost of product sales and contract manufacturing 195,707 131,284 107,486
Research and development 97,384 108,290 119,186
Selling, general and administrative 143,497 143,686 121,145
Income from operations 124,285 105,522 141,514
Other income (expense):      
Interest income 1,753 1,053 572
Interest expense (6,590) (7,617) (6,523)
Other income (expense), net (815) 263 153
Total other expense, net (5,652) (6,301) (5,798)
Income from continuing operations before provision for income taxes 118,633 99,221 135,716
Provision for income taxes 36,039 36,697 44,300
Net Income from continuing operations 82,594 62,524 91,416
Net loss from discontinued operations 0 (10,748) (28,546)
Net income $ 82,594 $ 51,776 $ 62,870
Net income (loss) per share - basic:      
Net income per share from continuing operations-basic (in dollars per share) $ 1.98 $ 1.56 $ 2.37
Net loss per share from discontinued operations-basic (in dollars per share) 0 (0.27) (0.74)
Net income per share-basic (in dollars per share) 1.98 1.29 1.63
Net income (loss) per share - diluted:      
Net income from continuing operations-diluted (in dollars per share) 1.71 1.35 2.02
Net loss per share from discontinued operations-diluted (in dollars per share) 0 (0.22) (0.61)
Net income per share-diluted (in dollars per share) [1] $ 1.71 $ 1.13 $ 1.41
Weighted-average number of shares - basic (in shares) 41,816,431 40,184,159 38,595,435
Weighted-average number of shares - diluted (in shares) 50,327,937 49,335,112 47,255,842
[1] See "Earnings per share" footnote for details on calculation.