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Discontinued operations (Details) - USD ($)
$ in Thousands
 12 Months Ended
Aug. 01, 2016
Dec. 31, 2016
Dec. 31, 2015
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]      
Percentage of outstanding shares distributed 100.00%    
Record date for distribution Jul. 22, 2016    
Number of shares received (in shares) 1    
Number of shares held (in shares) 2    
Number of common stock distributed (in shares) 20,230,000    
Aptevo [Member]      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]      
Unsecured debt $ 20,000    
Revenues [Abstract]      
Product sales   $ 21,183 $ 27,947
Collaborations   187 5,511
Total revenues   21,370 33,458
Operating expense [Abstract]      
Cost of product sales   11,556 16,809
Research and development   18,024 34,811
Selling, general and administrative   23,792 27,313
Loss from operations   (32,002) (45,475)
Other income (expense), net [Abstract]      
Other income (expense), net   (41) (472)
Loss from discontinued operations before benefit from income taxes   (32,043) (45,947)
Benefit from income taxes   (21,295) (17,401)
Net loss from discontinued operations   (10,748) (28,546)
Net Cash Provided by (Used in) Discontinued Operations [Abstract]      
Net cash used in operating activities   (10,299) (12,716)
Net cash used in investing activities   (1,926) (1,518)
Net cash provided by financing activities   7,733 15,012
Net increase (decrease) in cash and cash equivalents   $ (4,492) $ 778