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Acquisitions (Details) - USD ($)
$ in Thousands
 12 Months Ended
Oct. 06, 2017
Oct. 02, 2017
Dec. 31, 2017
Dec. 31, 2016
Fair value of tangible assets acquired and liabilities assumed [Abstract]        
Goodwill     $ 49,130 $ 41,001
Sanofi [Member]        
Summary of total purchase price [Abstract]        
Amount of cash paid to Sanofi $ 117,500      
Fair value of contingent purchase consideration 2,200      
Total purchase price 119,700      
Fair value of tangible assets acquired and liabilities assumed [Abstract]        
Inventory 74,876      
Property, plant and equipment 19,995      
Total fair value of tangible assets acquired and liabilities assumed 94,871      
Acquired intangible asset 16,700      
Goodwill 8,129      
Total purchase price $ 119,700      
ACAM2000 [Member]        
Business Acquisition [Line Items]        
Term of contract under acquisition 10 years      
Value of contract $ 425,000      
Amount for deliveries of product to the SNS 160,000      
Upfront cash payment 97,500      
Amount of payment for manufacturing related milestones 20,000      
Amount of payment for regulatory related milestones $ 7,500   7,500  
Fair value of tangible assets acquired and liabilities assumed [Abstract]        
Present value discount rate 15.50%      
Amortization period of intangible asset 10 years      
Transaction costs related to acquisition     $ 2,500  
Raxibacumab [Member]        
Business Acquisition [Line Items]        
Upfront cash payment   $ 76,000    
Amount of payment for manufacturing related milestones   20,000    
Capitalized transaction costs   $ 1,600    
Fair value of tangible assets acquired and liabilities assumed [Abstract]        
Amortization period of intangible asset   10 years