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Fair value measurements (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Unobservable Input Reconciliation [Roll Forward]    
Balance, beginning of period $ 13,185 $ 25,155
(Income) expense included in earnings 7,830 (10,857)
Settlements (10,941) (1,113)
Purchases, sales and issuances 2,200  
Balance, end of period 12,274 13,185
RSDL [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Fair value adjustment for contingent obligations 2,700 (5,400)
Evolva Holding SA 035 & Unither [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Fair value adjustment for contingent obligations (200) $ (5,400)
ACAM2000 [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Fair value adjustment for contingent obligations 5,300  
Amount of payment for regulatory related milestones $ 7,500