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Intangible assets and goodwill (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Cost Basis [Abstract]      
Intangible Assets, Beginning Balance $ 57,099    
Additions 94,304    
Intangible Assets, Ending Balance 151,403 $ 57,099  
Accumulated Amortization [Abstract]      
Accumulated Amortization, Beginning Balance (23,234)    
Amortization 8,572 6,893 $ 7,376
Accumulated Amortization, Ending balance (31,806) (23,234)  
Net book value of intangible assets $ 119,597    
Intangible assets, weighted average useful life 105 months    
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract]      
2018 $ 15,647    
2019 15,168    
2020 15,087    
2021 13,596    
2022 and beyond 60,099    
Net book value of intangible assets 119,597    
Goodwill, Cost Basis [Abstract]      
Goodwill, Beginning Balance 41,001    
Goodwill, Additions 8,129    
Goodwill, Ending Balance 49,130 41,001  
Therapeutics and Vaccines [Member]      
Goodwill, Cost Basis [Abstract]      
Goodwill, Beginning Balance 24,349    
Goodwill, Additions 8,129    
Goodwill, Ending Balance 32,478 24,349  
Contract Manufacturing [Member]      
Goodwill, Cost Basis [Abstract]      
Goodwill, Beginning Balance 6,736    
Goodwill, Additions 0    
Goodwill, Ending Balance 6,736 6,736  
Medical Devices [Member]      
Goodwill, Cost Basis [Abstract]      
Goodwill, Beginning Balance 9,916    
Goodwill, Additions 0    
Goodwill, Ending Balance $ 9,916 $ 9,916