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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Cash flows from operating activities:      
Net income $ 82,594 $ 51,776 $ 62,870
Adjustments to reconcile to net cash provided by (used in) operating activities:      
Stock-based compensation expense 15,213 18,477 15,848
Depreciation and amortization 42,572 38,229 35,335
Income taxes 3,259 5,190 3,464
Change in fair value of contingent obligations 7,830 (10,838) (10,599)
Impairment of intangible assets (including IPR&D) 0 701 9,827
Impairment and abandonment of long-lived assets 1,936 5,569 1,147
Bad debt expense 0 0 3,481
Excess tax benefits from stock-based compensation 0 (10,619) (11,281)
Other 1,011 452 271
Changes in operating assets and liabilities:      
Accounts receivable (4,810) (22,446) (64,351)
Inventories 6,066 (9,026) (11,262)
Income taxes 20,067 (3,424) (5,492)
Prepaid expenses and other assets (3,730) (2,089) 2,319
Accounts payable 16,134 (14,791) 4,749
Accrued expenses and other liabilities 1,626 624 45
Accrued compensation 3,349 2,236 2,680
Provision for chargebacks 0 0 (8)
Deferred revenue 15,022 4,602 3,474
Net cash provided by operating activities 208,139 54,623 42,517
Cash flows from investing activities:      
Purchases of property, plant and equipment (54,828) (76,257) (44,812)
Acquisitions (195,104) 0 (650)
Net cash used in investing activities (249,932) (76,257) (45,462)
Cash flows from financing activities:      
Proceeds from long-term debt obligations 0 0 2,000
Issuance of common stock upon exercise of stock options 19,346 17,125 25,961
Excess tax benefits from stock-based compensation 0 10,619 11,281
Debt issuance costs (1,426) 0 0
Taxes paid on behalf of employees for equity activity (4,260) (1,136) 1,942
Payments of notes payable (20,000) 0 0
Distribution to Aptevo 0 (45,000) 0
Contingent consideration payments (10,941) (1,385) (5,693)
Restricted cash (1,043) 0 0
Purchase of treasury stock (33,077) 0 (100)
Net cash (used in) provided by financing activities (51,401) (19,777) 35,391
Effect of exchange rate changes on cash and cash equivalents (27) 129 (150)
Net (decrease) increase in cash and cash equivalents (93,221) (41,282) 32,296
Cash and cash equivalents at beginning of year 271,513 312,795 280,499
Cash and cash equivalents at end of year 178,292 271,513 312,795
Supplemental disclosure of cash flow information:      
Cash paid during the year for interest 8,416 8,210 7,751
Cash paid during the year for income taxes 11,977 10,081 28,271
Supplemental information on non-cash investing and financing activities:      
Purchases of property, plant and equipment unpaid at year end $ 4,587 $ 13,459 $ 4,379