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Equity (Tables) | 3 Months Ended
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Mar. 31, 2022
Stockholders' Equity Note [Abstract] |
Share-based Payment Arrangement, Expensed and Capitalized, Amount | Share-based compensation expense was recorded in the following financial statement line items:
| Three Months Ended March 31, |
| 2022 |  | 2021 |  |  |
Cost of product sales | $ | 1.7 |  |  | $ | 1.5 |  |  |  |
Cost of contract development and manufacturing | 0.4 |  |  | 0.2 |  |  |  |
Research and development | 1.1 |  |  | 1.4 |  |  |  |
Selling, general and administrative | 6.7 |  |  | 7.4 |  |  |  |
Total share-based compensation expense | $ | 9.9 |  |  | $ | 10.5 |  |  |  |
Schedule of Accumulated Other Comprehensive Income (Loss) | The following table includes changes in accumulated other comprehensive income (loss), net of tax by component:
|  | Defined Benefit Pension Plan |  | Derivative Instruments |  | Foreign Currency Translation Losses |  | Total
(in millions, net of tax) |
Balance, December 31, 2021 |  | $ | (4.0) |  |  | $ | (4.5) |  |  | $ | (7.6) |  |  | $ | (16.1) |
Other comprehensive (loss) income before reclassifications |  | — |  |  | 4.9 |  |  | 0.5 |  |  | 5.4 |
Amounts reclassified from accumulated other comprehensive income |  | — |  |  | 1.4 |  |  | — |  |  | 1.4 |
Net current period other comprehensive income (loss) |  | — |  |  | 6.3 |  |  | 0.5 |  |  | 6.8 |
Balance, March 31, 2022 |  | $ | (4.0) |  |  | $ | 1.8 |  |  | $ | (7.1) |  |  | $ | (9.3) |
Balance, December 31, 2020 |  | $ | (7.7) |  |  | $ | (11.0) |  |  | $ | (6.6) |  |  | $ | (25.3) |
Other comprehensive (loss) income before reclassifications |  | — |  |  | 1.7 |  |  | (2.2) |  |  | (0.5) |
Amounts reclassified from accumulated other comprehensive income |  | — |  |  | 1.4 |  |  | — |  |  | 1.4 |
Net current period other comprehensive income (loss) |  | — |  |  | 3.1 |  |  | (2.2) |  |  | 0.9 |
Balance, March 31, 2021 |  | $ | (7.7) |  |  | $ | (7.9) |  |  | $ | (8.8) |  |  | $ | (24.4) |
Comprehensive Income (Loss) | The following table presents the tax effects related to each component of accumulated other comprehensive (loss) income:
| March 31, 2022 |  | March 31, 2021
| Pretax |  | Tax Benefit (Expense) |  | Net of tax |  | Pretax |  | Tax Benefit (Expense) |  | Net of tax
Derivative Instruments | $ | 8.6 |  |  | $ | (2.3) |  |  | $ | 6.3 |  |  | $ | 2.4 |  |  | $ | 0.7 |  |  | $ | 3.1 |
Foreign Currency Translation Losses | 0.7 |  |  | (0.2) |  |  | 0.5 |  |  | (2.2) |  |  | — |  |  | (2.2) |
Total Adjustments | $ | 9.3 |  |  | $ | (2.5) |  |  | $ | 6.8 |  |  | $ | 0.2 |  |  | $ | 0.7 |  |  | $ | 0.9 |

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