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Property, plant and equipment, net
 9 Months Ended
Sep. 30, 2022
Property Plant and Equipment Income Statement Disclosures [Abstract]  
Property, plant and equipment, net Property, plant and equipment, net
Property, plant and equipment, net consisted of the following:
September 30, 2022December 31, 2021
Land and improvements$53.5 $52.1 
Buildings, building improvements and leasehold improvements321.9 269.7 
Furniture and equipment551.2 513.5 
Software65.3 60.7 
Construction-in-progress181.0 223.2 
Property, plant and equipment, gross$1,172.9 $1,119.2 
Less: Accumulated depreciation & amortization(366.2)(319.1)
Total property, plant and equipment, net$806.7 $800.1 
As of September 30, 2022 and December 31, 2021, construction-in-progress primarily included costs incurred related to construction to advance the Company's CDMO capabilities.
Property, plant and equipment, net is stated at cost, less accumulated depreciation and amortization. During the nine months ended September 30, 2022, the Company recorded accelerated depreciation of $12.7 million reflecting a shortening of the useful life of certain property, plant and equipment which were to be used in the manufacturing process to fulfill the manufacturing services agreement with Janssen. For additional information related to the termination of the Agreement, refer to Note 10, "Revenue recognition".