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Stockholders' equity - Stock-based Compensation Expense (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total share-based compensation expense | $ 45.1 | $ 42.4 | $ 51.8
Cost of product sales | Products |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total share-based compensation expense | 7.3 | 6.4 | 8.9
Cost of product sales | Contract Development And Manufacturing |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total share-based compensation expense | 1.8 | 1.1 | 3.5
Research and development |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total share-based compensation expense | 5.4 | 5.0 | 8.4
Selling, general and administrative |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Total share-based compensation expense | $ 30.6 | $ 29.9 | $ 31.0

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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