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Property, plant and equipment, net | 12 Months Ended
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Dec. 31, 2022
Property Plant and Equipment Income Statement Disclosures [Abstract] |
Property, plant and equipment, net | Property, plant and equipment, net Property, plant and equipment, net consists of the following:
| December 31,
| 2022 |  | 2021
Land and improvements | $ | 54.9 |  |  | $ | 52.1 |
Buildings, building improvements and leasehold improvements | 327.9 |  |  | 269.7 |
Furniture and equipment | 567.5 |  |  | 513.5 |
Software | 65.6 |  |  | 60.7 |
Construction-in-progress | 185.5 |  |  | 223.2 |
Property, plant and equipment, gross | 1,201.4 |  |  | 1,119.2 |
Less: Accumulated depreciation and amortization | (383.8) |  |  | (319.1) |
Total property, plant and equipment, net | $ | 817.6 |  |  | $ | 800.1 |
For the years ended December 31, 2022 and 2021, construction-in-progress primarily includes costs incurred related to construction to advance the Company's CDMO capabilities. Property, plant and equipment, net is stated at cost, less accumulated depreciation and amortization. During the year ended December 31, 2022, the Company recorded accelerated depreciation of $12.7 million reflecting a shortening of the useful life of certain property, plant and equipment which were to be used in the manufacturing process to fulfill the Agreement with Janssen. For additional information related to the termination of the Agreement, refer to Note 12 "Revenue recognition". Depreciation and amortization expense associated with property, plant and equipment was $83.4 million, $62.2 million and $50.1 million for the years ended December 31, 2022, 2021, and 2020, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI https://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI https://asc.fasb.org/extlink&oid=126982197&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99779-112916 + Details
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