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Property, plant and equipment, net
 12 Months Ended
Dec. 31, 2022
Property Plant and Equipment Income Statement Disclosures [Abstract]  
Property, plant and equipment, net Property, plant and equipment, net
Property, plant and equipment, net consists of the following:
 
December 31,
20222021
Land and improvements$54.9 $52.1 
Buildings, building improvements and leasehold improvements327.9 269.7 
Furniture and equipment567.5 513.5 
Software65.6 60.7 
Construction-in-progress185.5 223.2 
Property, plant and equipment, gross1,201.4 1,119.2 
Less: Accumulated depreciation and amortization(383.8)(319.1)
Total property, plant and equipment, net$817.6 $800.1 
For the years ended December 31, 2022 and 2021, construction-in-progress primarily includes costs incurred related to construction to advance the Company's CDMO capabilities.
Property, plant and equipment, net is stated at cost, less accumulated depreciation and amortization. During the year ended December 31, 2022, the Company recorded accelerated depreciation of $12.7 million reflecting a shortening of the useful life of certain property, plant and equipment which were to be used in the manufacturing process to fulfill the Agreement with Janssen. For additional information related to the termination of the Agreement, refer to Note 12 "Revenue recognition".
Depreciation and amortization expense associated with property, plant and equipment was $83.4 million, $62.2 million and $50.1 million for the years ended December 31, 2022, 2021, and 2020, respectively.