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Stock-based compensation and stockholders' equity - Schedule of Stock-based Compensation Expense (Details) - USD ($) $ in Millions | 3 Months Ended
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Mar. 31, 2023 | Mar. 31, 2022
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |  |
Total stock-based compensation expense | $ 6.8 | $ 9.9
Cost of product sales | Products |  |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |  |
Total stock-based compensation expense | 1.4 | 1.7
Cost of product sales | CDMO |  |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |  |
Total stock-based compensation expense | 0.3 | 0.4
R&D |  |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |  |
Total stock-based compensation expense | 0.7 | 1.1
Selling, general and administrative |  |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |  |
Total stock-based compensation expense | $ 4.4 | $ 6.7

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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