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Pay vs Performance Disclosure - USD ($) | 8 Months Ended | 10 Months Ended | 12 Months Ended | 42 Months Ended
--- | --- | --- | --- | ---
Feb. 20, 2024 | Dec. 31, 2024 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Jun. 23, 2023
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Pay vs Performance Disclosure, Table |  |  |
Fiscal Year | Summary Compensation Table Total for PEO (Miller) ($)(1) | Summary Compensation Table Total for PEO (Papa) ($)(1) | Compensation Actually Paid to PEO (Miller) ($)(1)(2) | Compensation Actually Paid to PEO (Papa) ($)(1)(2) | Average Summary Compensation Table Total for Non-PEO NEOs ($)(3) | Average Compensation Actually Paid to Non-PEO NEOs ($)(2)(3) |  | Value of Initial Fixed $100 Investment Based on | Net Income (Loss) (in millions) ($)(5) | Total Revenues (in millions) ($)(5)
| Total Shareholder Return ($) | Peer Group Total Shareholder Return ($)(4)
2024 | 218,750 |  | 5,862,562 |  | 218,750 |  | 19,531,513 |  | 1,788,883 |  | 2,945,103 |  |  | 17.72 |  | 147.24 |  | (190.6) |  | 1,043.6 |
2023 | 766,667 |  | 5,103,858 |  | 766,667 |  | 393,077 |  | 1,813,193 |  | 462,669 |  |  | 4.45 |  | 146.27 |  | (760.5) |  | 1,049.3 |
2022 | — |  | 7,578,573 |  | — |  | 508,270 |  | 3,393,116 |  | 951,561 |  |  | 21.89 |  | 140.85 |  | (211.6) |  | 1,117.5 |
2021 | — |  | 6,932,076 |  | — |  | 532,388 |  | 2,469,172 |  | 192,682 |  |  | 80.57 |  | 121.8 |  | 219.5 |  | 1,773.6 |
2020 | — |  | 5,569,978 |  | — |  | 10,223,966 |  | 2,457,336 |  | 5,035,083 |  |  | 166.08 |  | 108.63 |  | 305.8 |  | 1,577.3 |
Company Selected Measure Name |  |  | Total Revenues |  |  |  |  |
Named Executive Officers, Footnote |  |  | Mr. Kramer was our principal executive officer (PEO) for each of 2020, 2021, 2022 and until June 24, 2023. Mr. Miller was the Company’s Interim CEO from June 24, 2023 until February 21, 2024. Mr. Papa is the Company’s current CEO starting February 21, 2024.The non-PEO NEOs for 2024 are Mr. Lindahl, Ms. Glessner, Mr. Williams, Mr. Hartzel and Ms. Fox, our former EVP, General Counsel, Legal Affairs and Corporate Secretary. The 2023 non-PEO NEOs are Mr. Lindahl, Mr. Havey, our former Chief Operating Officer, Ms. Fox, Ms. Glessner and Mr. Williams. For 2022, the non-PEO NEOS were Mr. Lindahl, Mr. Havey, Ms. Fox and Mr. Saran, our former Chief Strategy and Development Officer, and for each of 2021 and 2020 the non-PEO NEOs were Mr. El-Hibri, Mr. Lindahl, Mr. Havey and Mr. Saran. Supplemental tables reconciling compensation reported in our summary compensation table to CAP for the average of our non-PEO NEOs is provided below. |  |  |  |  |
Peer Group Issuers, Footnote |  |  | Peer Group reflects published data for the S&P 500 Biotechnology Index. |  |  |  |  |
Adjustment To PEO Compensation, Footnote |  |  | PEO SCT to CAP Reconciliation
Fiscal Year | Reported Summary Compensation Table Total for PEO (Miller) ($) | Reported Summary Compensation Table Total for PEO (Papa) ($) | Reported Value of Equity Awards in the Summary Compensation Table(1) ($) | Equity Award Adjustments(1) ($) | Compensation Actually Paid to PEO (Miller) ($) | Compensation Actually Paid to PEO ($) |
2024 | 218,750 |  | 5,862,562 |  | (2,489,050) |  | 16,158,000 |  | 218,750 |  | 19,531,513 |  |
2023 | 766,667 |  | 5,103,858 |  | (3,398,039) |  | (1,312,741) |  | 766,667 |  | 393,077 |  |
2022 | N/A | 7,578,573 |  | (6,231,882) |  | (838,421) |  | N/A | 508,270 |  |
2021 | N/A | 6,932,076 |  | (4,998,767) |  | (1,400,921) |  | N/A | 532,388 |  |
2020 | N/A | 5,569,978 |  | (3,442,423) |  | 8,096,411 |  | N/A | 10,223,966 |  |
1.Mr. Miller was not eligible to receive equity in his role as Interim CEO and did not receive equity awards from the Company prior to his service as Interim CEO. Accordingly, the equity award columns apply only to Mr. Papa in 2024 and Mr. Kramer for years 2020 through 2023. PEO Equity Award Adjustment Reconciliation(1)
Fiscal Year | Year-End Fair Value of Awards Granted During Year That Remain Unvested as of Year End ($) | Year-over-Year Change in Fair Value of Outstanding and Unvested Equity Awards ($) | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Covered Year ($) | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Covered Year ($) | Year-end Fair Value of Equity Awards that Failed to Meet Vesting Conditions in the Covered Year ($) | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation ($) | Total Equity Award Adjustments ($) |
2024 | 16,158,000 |  | — |  | — |  | — |  | — |  | — |  | 16,158,000 |  |
2023 | — |  | — |  | — |  | 80,295 |  | (1,393,036) |  | — |  | (1,312,741) |  |
2022 | 1,391,610 |  | (1,603,115) |  | — |  | (626,916) |  | — |  | — |  | (838,421) |  |
2021 | 1,869,759 |  | (3,301,247) |  | — |  | 30,567 |  | — |  | — |  | (1,400,921) |  |
2020 | 5,854,355 |  | 1,898,642 |  | — |  | 343,414 |  | — |  | — |  | 8,096,411 |  |
1.Mr. Miller was not eligible to receive equity in his role as Interim CEO. Accordingly, this table applies only to Mr. Kramer for years 2020 through 2023 and Mr. Papa for 2024. |  |  |  |  |
Non-PEO NEO Average Total Compensation Amount |  |  | $ 1,788,883 | $ 1,813,193 | $ 3,393,116 | $ 2,469,172 | $ 2,457,336 |
Non-PEO NEO Average Compensation Actually Paid Amount |  |  | $ 2,945,103 | 462,669 | 951,561 | 192,682 | 5,035,083 |
Adjustment to Non-PEO NEO Compensation Footnote |  |  | Average non-PEO NEO SCT to CAP Reconciliation
Fiscal Year | Average Reported Summary Compensation Table Total for non-PEO NEOs ($) | Average Reported Value of Equity Awards in the Summary Compensation Table ($) | Total Average Equity Award Adjustments ($) | Average Compensation Actually Paid to non-PEO NEOs ($) |
2024 | 1,788,883 |  | (269,975) |  | 1,426,196 |  | 2,945,103 |  |
2023 | 1,813,193 |  | (881,054) |  | (469,470) |  | 462,669 |  |
2022 | 3,393,116 |  | (2,640,104) |  | 198,549 |  | 951,561 |  |
2021 | 2,469,172 |  | (1,539,799) |  | (736,691) |  | 192,682 |  |
2020 | 2,457,336 |  | (1,406,360) |  | 3,984,107 |  | 5,035,083 |  |
Average non-PEO NEO Equity Award Adjustment Reconciliation
Fiscal Year | Average Year-End Fair Value of Awards Granted During Year That Remain Unvested as of Year End ($) | Year-over-Year Average Change in Fair Value of Outstanding and Unvested Equity Awards ($) | Average Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Covered Year ($) | Year-over-Year Average Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Covered Year ($) | Average Year-End Fair Value of Equity Awards that Failed to Meet Vesting Conditions in the Covered Year ($) | Average Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation ($) | Total Average Equity Award Adjustments ($) |
2024 | 894,360 |  | 333,544 |  | — |  | 198,291 |  | — |  | — |  | 1,416,195 |  |
2023 | 147,810 |  | (604,648) |  | — |  | (12,632) |  | — |  | — |  | (469,470) |  |
2022 | 764,901 |  | (389,222) |  | — |  | (177,130) |  | — |  | — |  | 198,549 |  |
2021 | 575,964 |  | (1,417,932) |  | — |  | 105,276 |  | — |  | — |  | (736,691) |  |
2020 | 2,391,709 |  | 1,136,285 |  | — |  | 456,113 |  | — |  | — |  | 3,984,107 |  |
Compensation Actually Paid vs. Total Shareholder Return |  |  | (1) Relationship between compensation “actually paid” to each PEO and average actual compensation paid to the Company’s non-PEO NEOs and the Company’s cumulative total shareholder return (“TSR”) and comparison of company TSR and peer group TSR. PEO CAP applies to Mr. Kramer for years 2020 through 2023 and Mr. Papa for 2024. |  |  |  |  |
Compensation Actually Paid vs. Net Income |  |  | (2) Relationship between compensation “actually paid” to each PEO and average actual compensation paid to the Company’s non-PEO NEOs and the Company’s net income (loss). PEO CAP applies to Mr. Kramer for years 2020 through 2023 and Mr. Papa for 2024. |  |  |  |  |
Compensation Actually Paid vs. Company Selected Measure |  |  | (3) Relationship between compensation “actually paid” to each PEO and average actual compensation paid to non-PEO NEOs and Total Revenues. PEO CAP applies to Mr. Kramer for years 2020 through 2023 and Mr. Papa for 2024. |  |  |  |  |
Total Shareholder Return Vs Peer Group |  |  | (1) Relationship between compensation “actually paid” to each PEO and average actual compensation paid to the Company’s non-PEO NEOs and the Company’s cumulative total shareholder return (“TSR”) and comparison of company TSR and peer group TSR. PEO CAP applies to Mr. Kramer for years 2020 through 2023 and Mr. Papa for 2024. |  |  |  |  |
Tabular List, Table |  |  |
Measure 1 | Total Revenues (Company Selected Measure)
Measure 2 | Adjusted EBITDA Margin
Measure 3 | Adjusted Net Income (Loss)
Total Shareholder Return Amount |  |  | $ 17.72 | 4.45 | 21.89 | 80.57 | 166.08 |
Peer Group Total Shareholder Return Amount |  |  | 147.24 | 146.27 | 140.85 | 121.8 | 108.63 |
Net Income (Loss) |  |  | $ (190,600,000) | $ (760,500,000) | $ (211,600,000) | $ 219,500,000 | $ 305,800,000 |
Company Selected Measure Amount |  |  | 1,043,600,000 | 1,049,300,000 | 1,117,500,000 | 1,773,600,000 | 1,577,300,000 |
PEO Name | Mr. Miller | Mr. Papa |  |  |  |  |  | Mr. Kramer
Additional 402(v) Disclosure |  |  | The dollar amounts reported in the “Compensation Actually Paid to PEO” column, the “Compensation Actually paid to CEO (Miller)” column and the “Average Compensation Actually Paid to Non-PEO Named Executive Officers” column represent the amount of “compensation actually paid” (“CAP”) to each of our PEOs and the “average compensation actually paid” to our non-PEO NEOs, respectively, as computed in accordance with Item 402(v) of Regulation S-K. While SEC rules require us to disclose these amounts, they do not correlate to actual amounts that will or may be paid to our NEOs. The actual amounts that will or may be paid to each NEO will be determined following the completion of the applicable service and/or performance period based upon the actual achievement over such service and/or performance period. Supplemental tables reconciling compensation reported in our summary compensation table to CAP for our PEOs is provided below. Net income (loss) and Total Revenues for each year shown, as disclosed in the Company’s annual report on Form 10-K for the corresponding year. Total Revenues is our “Company-Selected Measure” as set forth in Regulation S-K 402(v). Note that the restatement identified in the Company’s Form 10-K/A filed on December 11, 2023 did not require a recovery in connection with the Company’s Executive Compensation Recovery Policy. |  |  |  |  |
Measure:: 1 |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Name |  |  | Total Revenues (Company Selected Measure) |  |  |  |  |
Measure:: 2 |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Name |  |  | Adjusted EBITDA Margin |  |  |  |  |
Measure:: 3 |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Name |  |  | Adjusted Net Income (Loss) |  |  |  |  |
Miller [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
PEO Total Compensation Amount |  |  | $ 218,750 | $ 766,667 |  |  |  |
PEO Actually Paid Compensation Amount |  |  | 218,750 | 766,667 |  |  |  |
Papa [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
PEO Total Compensation Amount |  |  | 5,862,562 | 5,103,858 | $ 7,578,573 | $ 6,932,076 | $ 5,569,978 |
PEO Actually Paid Compensation Amount |  |  | 19,531,513 | 393,077 | 508,270 | 532,388 | 10,223,966 |
PEO [Member] | Equity Awards Adjustments |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 16,158,000 | (1,312,741) | (838,421) | (1,400,921) | 8,096,411 |
PEO [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | (2,489,050) | (3,398,039) | (6,231,882) | (4,998,767) | (3,442,423) |
Non-PEO NEO [Member] | Equity Awards Adjustments |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 1,426,196 | (469,470) | 198,549 | (736,691) | 3,984,107 |
Non-PEO NEO [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | (269,975) | (881,054) | (2,640,104) | (1,539,799) | (1,406,360) |
Equity Awards Adjustments | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 16,158,000 | (1,312,741) | (838,421) | (1,400,921) | 8,096,411 |
Equity Awards Adjustments | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 1,416,195 | (469,470) | 198,549 | (736,691) | 3,984,107 |
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 16,158,000 | 0 | 1,391,610 | 1,869,759 | 5,854,355 |
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 894,360 | 147,810 | 764,901 | 575,964 | 2,391,709 |
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | 0 | (1,603,115) | (3,301,247) | 1,898,642 |
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 333,544 | (604,648) | (389,222) | (1,417,932) | 1,136,285 |
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | 0 | 0 | 0 | 0 |
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | 0 | 0 | 0 | 0 |
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | 80,295 | (626,916) | 30,567 | 343,414 |
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 198,291 | (12,632) | (177,130) | 105,276 | 456,113 |
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | (1,393,036) | 0 | 0 | 0 |
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | 0 | 0 | 0 | 0 |
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year | PEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | 0 | 0 | 0 | 0 | 0 |
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year | Non-PEO NEO [Member] |  |  |  |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |  |  |  |
Adjustment to Compensation, Amount |  |  | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 |

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