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Condensed Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash Flows From Operating Activities: |  |  |
Net loss | $ (275,528,000) | $ (32,693,000) | $ (18,332,000)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Loss on extinguishment of debt | 251,754,000 | 0 | 0
Depreciation and amortization | 20,247,000 | 9,869,000 | 2,415,000
Amortization of debt discount | 1,236,000 | 437,000 | 288,000
Interest expense on convertible note settled by issuance of common stock |  | 0 | 418,000
Unrealized (gain) loss on investments in equity securities | 1,386,000 | (845,000) | 102,000
Realized loss on investments in equity securities |  | 1,090,000 | 0
Unrealized (gain) loss on investments in equity securities | 81,000 | 32,000 | (82,000)
Stock-based compensation expense | 15,345,000 | 8,916,000 | 6,962,000
Accelerated stock-based compensation expense |  | 0 | 9,562,000
Loss on disposal of property and equipment | 542,000 | 384,000 | 274,000
Provision for bad debt | 26,000 | 197,000 | 42,000
Changes in operating assets and liabilities, net of effects of acquisition: |  |  |
Accounts receivable | (7,270,000) | (2,617,000) | (3,596,000)
Inventories | (5,979,000) | 1,322,000 | (253,000)
Prepaid expenses and other current assets | 3,056,000 | (7,520,000) | (345,000)
Deposits | 211,000 | (152,000) | (86,000)
Change in operating lease right-of-use assets and lease liabilities | 562,000 | 134,000 | (6,000)
Accounts payable and other accrued expenses | (398,000) | 4,245,000 | 570,000
Accrued compensation and related expenses | 2,522,000 | 3,143,000 | 641,000
Deferred revenue | 102,000 | (309,000) | 81,000
Net deferred tax (asset) liability | 231,000 | (499,000) | 21,000
Net cash provided by (used in) operating activities | 8,126,000 | (14,866,000) | (1,324,000)
Cash Flows From Investing Activities: |  |  |
Purchases of property and equipment | (23,882,000) | (8,918,000) | (5,336,000)
Software development costs | (870,000) | (551,000) | 0
Purchases of short-term investments | (482,707,000) | (158,736,000) | (43,196,000)
Sales/maturities of short-term investments | 44,000,000 | 149,233,000 | 5,995,000
Patent and trademark costs | (255,000) | (200,000) | (73,000)
Cash paid for acquisitions | (5,540,000) | (363,140,000) | (20,317,000)
Net cash used in investing activities | (469,254,000) | (382,312,000) | (62,927,000)
Cash Flows From Financing Activities: |  |  |
Proceeds from exercise of stock options and warrants | 8,995,000 | 9,388,000 | 5,363,000
Proceeds from the issuance of convertible senior notes | 40,068,000 | 115,000,000 | 0
Proceeds from issuance of common stock, net of issuance costs |  | 28,160,000 | 0
Proceeds from issuance of Series C convertible preferred stock, net of issuance costs | 248,911,000 | 237,225,000 | 0
Payment of deferred financing costs |  | (4,118,000) | 0
Repayment of finance lease liabilities | (60,000) | (70,000) | (23,000)
Repayment of note payable | (3,397,000) | 0 | 0
Proceeds from tender offer, net of offering costs | 269,825,000 | 0 | 68,811,000
Net cash provided by financing activities | 564,342,000 | 385,585,000 | 74,151,000
Effect of exchange rate changes on cash and cash equivalents | (986,000) | 1,231,000 | 8,000
Net change in cash and cash equivalents | 102,228,000 | (10,362,000) | 9,908,000
Cash and cash equivalents - beginning of year | 36,873,000 | 47,235,000 | 37,327,000
Cash and cash equivalents - end of year | 139,101,000 | 36,873,000 | 47,235,000
Supplemental Disclosure of Cash Flow Information: |  |  |
Cash paid for interest | 3,297,000 | 1,823,000 | 707,000
Cash paid for income taxes | 1,315,000 | 60,000 | 14,000
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |  |  |
Net unrealized gain (loss) on available-for-sale debt securities | 3,958,000 | 161,000 | (28,000)
Reclassification of realized gain on available-for-sale debt securities to earnings | 27,000 | 3,000 | 23,000
Purchase of equipment through finance lease obligations |  | 205,000 | 0
Fixed assets included in accounts payable and accrued liabilities | 1,412,000 | 499,000 | 261,000
Paid-in-kind preferred stock dividend, including beneficial conversion feature | 8,196,000 | 2,844,000 | 0
Common stock issued for conversion of debt and accrued interest | $ 765,000 | $ 0 | $ 15,418,000

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