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Condensed Consolidated Statements of Stockholders' Equity - USD ($) | Preferred Stock [Member] Class A Preferred Stock Private Placement | Preferred Stock [Member] Class A Preferred Stock | Preferred Stock [Member] Class B Preferred Stock Private Placement | Preferred Stock [Member] Class B Preferred Stock | Preferred Stock [Member] Class C Preferred Stock | Common Stock [Member] Private Placement | Common Stock [Member] | Additional Paid-In Capital [Member] Private Placement | Additional Paid-In Capital [Member] | Accumulated Deficit [Member] Private Placement | Accumulated Deficit [Member] | Other Comprehensive Income (Loss) [Member] Private Placement | Other Comprehensive Income (Loss) [Member] | Private Placement | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2018 |  | $ 0 |  | $ 0 | $ 0 |  | $ 30,000 |  | $ 179,502,000 |  | $ (140,988,000) |  | $ 3,000 |  | $ 38,547,000
Balance (in shares) at Dec. 31, 2018 |  | 0 |  | 0 |  |  | 30,319,038 |  |  |  |  |  |  |  |
Net loss |  | $ 0 |  | $ 0 |  |  | $ 0 |  | 0 |  | (18,332,000) |  | 0 |  | (18,332,000)
Other comprehensive loss, net of taxes |  | 0 |  | 0 |  |  | 0 |  | 0 |  | 0 |  | (48,000) |  | (48,000)
Stock-based compensation expense |  | 0 |  | 0 |  |  | 0 |  | 6,871,000 |  | 0 |  | 0 |  | 6,871,000
Accelerated stock-based compensation expense |  | 0 |  | 0 |  |  | 0 |  | 9,562,000 |  | 0 |  | 0 |  | 9,562,000
Proceeds from public offering net of costs of $103,000 |  | $ 0 |  | $ 0 |  |  | 4,000 |  | 68,806,000 |  | 0 |  | 0 |  | 68,810,000
Stock Issued During Period Shares On Public Offer Net Cost |  | 0 |  | 0 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for board of director compensation |  | $ 0 |  | $ 0 |  |  | $ 0 |  | 91,000 |  | 0 |  | 0 |  | 91,000
Issuance of common stock for board of director compensation (in shares) |  | 0 |  | 0 |  |  | 5,753 |  |  |  |  |  |  |  |
Issuance of common stock in public offering, net of costs of $17.7 million (in shares) |  |  |  |  |  |  | 4,312,500 |  |  |  |  |  |  |  |
Issuance of common stock for convertible debt and accrued interest |  | $ 0 |  | $ 0 |  |  | $ 1,000 |  | 15,416,000 |  | 0 |  | 0 |  | 15,417,000
Issuance of common stock for convertible debt and accrued interest (in shares) |  | 0 |  | 0 |  |  | 1,172,305 |  |  |  |  |  |  |  |
Proceeds from exercise of stock options and warrants |  | $ 0 |  | $ 0 |  |  | $ 2,000 |  | 5,361,000 |  | 0 |  | 0 |  | 5,363,000
Proceeds from exercise of stock options and warrants (in shares) |  |  |  | 0 |  |  | 1,530,191 |  |  |  |  |  |  |  |
Balance at Dec. 31, 2019 |  | 0 |  | $ 0 | $ 0 |  | $ 37,000 |  | 285,609,000 |  | (159,320,000) |  | (45,000) |  | 126,281,000
Balance (in shares) at Dec. 31, 2019 |  |  |  | 0 |  |  | 37,339,787 |  |  |  |  |  |  |  |
Net loss |  | 0 |  | $ 0 |  |  | $ 0 |  | 0 |  | (32,693,000) |  | 0 |  | (32,693,000)
Other comprehensive loss, net of taxes |  | 0 |  | 0 |  |  | 0 |  | 0 |  | 0 |  | 5,421,000 |  | 5,421,000
Stock-based compensation expense |  | $ 0 |  | 0 |  |  | 0 |  | 8,833,000 |  | 0 |  | 0 |  | 8,833,000
Issuance of common stock for board of director compensation |  |  |  | 0 |  |  | $ 0 |  | 83,000 |  | 0 |  | 0 |  | 83,000
Issuance of common stock for board of director compensation (in shares) |  | 0 |  |  |  |  | 2,869 |  |  |  |  |  |  |  |
Cost of Series C preferred stock conversion |  | $ 0 |  | $ 0 |  |  | $ 0 |  | 237,225,000 |  | 0 |  | 0 |  | 237,225,000
Issuance of common stock in public offering, net of costs | $ 0 |  | $ 0 |  |  | $ 1,000 |  | $ 28,159,000 |  | $ 0 |  | $ 0 |  | $ 28,160,000 |
Issuance of common stock in public offering, net of costs of $17.7 million (in shares) |  |  | 0 | 0 | 250,000 | 675,536 | 0 |  |  |  |  |  |  |  |
Paid-in-kind preferred stock dividend, including beneficial conversion feature |  | 0 |  | $ 0 | $ 2,844,000 |  | $ 0 |  | (2,844,000) |  | 0 |  | 0 |  | 0
Proceeds from exercise of stock options and warrants |  | $ 0 |  | $ 0 |  |  | $ 2,000 |  | 9,386,000 |  | 0 |  | 0 |  | 9,388,000
Proceeds from exercise of stock options and warrants (in shares) |  | 0 |  | 0 |  |  | 1,818,866 |  |  |  |  |  |  |  |
Beneficial conversion feature of the Series C convertible preferred stock |  | $ 0 |  | $ 0 |  |  | $ 0 |  |  |  | 0 |  | 0 |  | 0
Deemed dividend on the Series C convertible preferred stock |  | 0 |  | 0 |  |  | 0 |  |  |  | 0 |  | 0 |  | 0
Balance at Dec. 31, 2020 |  | $ 0 |  | $ 0 | $ 2,844,000 |  | $ 40,000 |  | 566,451,000 |  | (192,013,000) |  | 5,376,000 |  | 382,698,000
Balance (in shares) at Dec. 31, 2020 |  | 0 |  | 0 | 250,000 |  | 39,837,058 |  |  |  |  |  |  |  |
Net loss |  | $ 0 |  | $ 0 |  |  | $ 0 |  | 0 |  | (275,528,000) |  | 0 |  | (275,528,000)
Other comprehensive loss, net of taxes |  | 0 |  | 0 |  |  | 0 |  | 0 |  | 0 |  | (6,619,000) |  | (6,619,000)
Stock-based compensation expense |  | 0 |  | 0 |  |  | 0 |  | 15,334,000 |  | 0 |  | 0 |  | 15,334,000
Issuance of common stock for board of director compensation |  | $ 0 |  | $ 0 |  |  | 229 |  | 11,000 |  | 0 |  | 0 |  | 11,000
Issuance of common stock for board of director compensation (in shares) |  | 0 |  | 0 |  |  |  |  |  |  |  |  |  |  |
Cost of Series C preferred stock conversion |  | $ 0 |  | $ 0 |  |  | 0 |  | (1,800,000) |  | 0 |  | 0 |  | (1,800,000)
Issuance of common stock in public offering, net of costs |  | $ 0 |  | $ 0 |  |  | $ 4,000 |  | 269,821,000 |  | 0 |  | 0 |  | 269,825,000
Issuance of common stock in public offering, net of costs of $17.7 million (in shares) |  | 0 |  | 0 |  |  | 4,356,059 |  |  |  |  |  |  |  |
Issuance of common stock for convertible debt and accrued interest |  | $ 0 |  | $ 0 |  |  | $ 3,000 |  | 248,908,000 |  | 0 |  | 0 |  | 248,911,000
Issuance of common stock for convertible debt and accrued interest (in shares) |  | 0 |  | 0 |  |  | 3,072,038 |  |  |  |  |  |  |  |
Conversion of Series C preferred shares to common stock |  | $ 0 |  | $ 0 | $ (765,000) |  | $ 1,000 |  | 764,000 |  | 0 |  | 0 |  | 0
Conversion of Series C preferred shares to common stock (in shares) |  | 0 |  | 0 | (50,000) |  | 1,312,860 |  |  |  |  |  |  |  |
Paid-in-kind preferred stock dividend, including beneficial conversion feature |  | $ 0 |  | $ 0 | $ 8,196,000 |  | $ 0 |  | (8,196,000) |  | 0 |  | 0 |  | 0
Proceeds from exercise of stock options and warrants |  | $ 0 |  | $ 0 |  |  | $ 2,000 |  | 8,994,000 |  | 0 |  | 0 |  | 8,996,000
Proceeds from exercise of stock options and warrants (in shares) |  | 0 |  | 0 |  |  | 1,037,910 |  |  |  |  |  |  |  |
Beneficial conversion feature of the Series C convertible preferred stock |  |  |  |  | (39,492,000) |  |  |  | 39,492,000 |  |  |  |  |  |
Deemed dividend on the Series C convertible preferred stock |  |  |  |  | 39,492,000 |  |  |  | (39,492,000) |  |  |  |  |  |
Balance at Dec. 31, 2021 |  | $ 0 |  | $ 0 | $ 10,275,000 |  | $ 50,000 |  | $ 1,100,287,000 |  | $ (467,541,000) |  | $ (1,243,000) |  | $ 641,828,000
Balance (in shares) at Dec. 31, 2021 |  | 0 |  | 0 | 200,000 |  | 49,616,154 |  |  |  |  |  |  |  |

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