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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
Preferred Stock [Member]
Class A Preferred Stock
Private Placement
Preferred Stock [Member]
Class A Preferred Stock
Preferred Stock [Member]
Class B Preferred Stock
Private Placement
Preferred Stock [Member]
Class B Preferred Stock
Preferred Stock [Member]
Class C Preferred Stock
Common Stock [Member]
Private Placement
Common Stock [Member]
Additional Paid-In Capital [Member]
Private Placement
Additional Paid-In Capital [Member]
Accumulated Deficit [Member]
Private Placement
Accumulated Deficit [Member]
Other Comprehensive Income (Loss) [Member]
Private Placement
Other Comprehensive Income (Loss) [Member]
Private Placement
Total
Balance at Dec. 31, 2018   $ 0   $ 0 $ 0   $ 30,000   $ 179,502,000   $ (140,988,000)   $ 3,000   $ 38,547,000
Balance (in shares) at Dec. 31, 2018   0   0     30,319,038                
Net loss   $ 0   $ 0     $ 0   0   (18,332,000)   0   (18,332,000)
Other comprehensive loss, net of taxes   0   0     0   0   0   (48,000)   (48,000)
Stock-based compensation expense   0   0     0   6,871,000   0   0   6,871,000
Accelerated stock-based compensation expense   0   0     0   9,562,000   0   0   9,562,000
Proceeds from public offering net of costs of $103,000   $ 0   $ 0     4,000   68,806,000   0   0   68,810,000
Stock Issued During Period Shares On Public Offer Net Cost   0   0                      
Issuance of common stock for board of director compensation   $ 0   $ 0     $ 0   91,000   0   0   91,000
Issuance of common stock for board of director compensation (in shares)   0   0     5,753                
Issuance of common stock in public offering, net of costs of $17.7 million (in shares)             4,312,500                
Issuance of common stock for convertible debt and accrued interest   $ 0   $ 0     $ 1,000   15,416,000   0   0   15,417,000
Issuance of common stock for convertible debt and accrued interest (in shares)   0   0     1,172,305                
Proceeds from exercise of stock options and warrants   $ 0   $ 0     $ 2,000   5,361,000   0   0   5,363,000
Proceeds from exercise of stock options and warrants (in shares)       0     1,530,191                
Balance at Dec. 31, 2019   0   $ 0 $ 0   $ 37,000   285,609,000   (159,320,000)   (45,000)   126,281,000
Balance (in shares) at Dec. 31, 2019       0     37,339,787                
Net loss   0   $ 0     $ 0   0   (32,693,000)   0   (32,693,000)
Other comprehensive loss, net of taxes   0   0     0   0   0   5,421,000   5,421,000
Stock-based compensation expense   $ 0   0     0   8,833,000   0   0   8,833,000
Issuance of common stock for board of director compensation       0     $ 0   83,000   0   0   83,000
Issuance of common stock for board of director compensation (in shares)   0         2,869                
Cost of Series C preferred stock conversion   $ 0   $ 0     $ 0   237,225,000   0   0   237,225,000
Issuance of common stock in public offering, net of costs $ 0   $ 0     $ 1,000   $ 28,159,000   $ 0   $ 0   $ 28,160,000  
Issuance of common stock in public offering, net of costs of $17.7 million (in shares)     0 0 250,000 675,536 0                
Paid-in-kind preferred stock dividend, including beneficial conversion feature   0   $ 0 $ 2,844,000   $ 0   (2,844,000)   0   0   0
Proceeds from exercise of stock options and warrants   $ 0   $ 0     $ 2,000   9,386,000   0   0   9,388,000
Proceeds from exercise of stock options and warrants (in shares)   0   0     1,818,866                
Beneficial conversion feature of the Series C convertible preferred stock   $ 0   $ 0     $ 0       0   0   0
Deemed dividend on the Series C convertible preferred stock   0   0     0       0   0   0
Balance at Dec. 31, 2020   $ 0   $ 0 $ 2,844,000   $ 40,000   566,451,000   (192,013,000)   5,376,000   382,698,000
Balance (in shares) at Dec. 31, 2020   0   0 250,000   39,837,058                
Net loss   $ 0   $ 0     $ 0   0   (275,528,000)   0   (275,528,000)
Other comprehensive loss, net of taxes   0   0     0   0   0   (6,619,000)   (6,619,000)
Stock-based compensation expense   0   0     0   15,334,000   0   0   15,334,000
Issuance of common stock for board of director compensation   $ 0   $ 0     229   11,000   0   0   11,000
Issuance of common stock for board of director compensation (in shares)   0   0                      
Cost of Series C preferred stock conversion   $ 0   $ 0     0   (1,800,000)   0   0   (1,800,000)
Issuance of common stock in public offering, net of costs   $ 0   $ 0     $ 4,000   269,821,000   0   0   269,825,000
Issuance of common stock in public offering, net of costs of $17.7 million (in shares)   0   0     4,356,059                
Issuance of common stock for convertible debt and accrued interest   $ 0   $ 0     $ 3,000   248,908,000   0   0   248,911,000
Issuance of common stock for convertible debt and accrued interest (in shares)   0   0     3,072,038                
Conversion of Series C preferred shares to common stock   $ 0   $ 0 $ (765,000)   $ 1,000   764,000   0   0   0
Conversion of Series C preferred shares to common stock (in shares)   0   0 (50,000)   1,312,860                
Paid-in-kind preferred stock dividend, including beneficial conversion feature   $ 0   $ 0 $ 8,196,000   $ 0   (8,196,000)   0   0   0
Proceeds from exercise of stock options and warrants   $ 0   $ 0     $ 2,000   8,994,000   0   0   8,996,000
Proceeds from exercise of stock options and warrants (in shares)   0   0     1,037,910                
Beneficial conversion feature of the Series C convertible preferred stock         (39,492,000)       39,492,000            
Deemed dividend on the Series C convertible preferred stock         39,492,000       (39,492,000)            
Balance at Dec. 31, 2021   $ 0   $ 0 $ 10,275,000   $ 50,000   $ 1,100,287,000   $ (467,541,000)   $ (1,243,000)   $ 641,828,000
Balance (in shares) at Dec. 31, 2021   0   0 200,000   49,616,154