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  <xsd:element name="NatureOfBusinessAbstract" id="cyrx_NatureOfBusinessAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquipmentAndFurnitureMember" id="cyrx_EquipmentAndFurnitureMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PatentsAndTrademarksMember" id="cyrx_PatentsAndTrademarksMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ReclassificationOfRealizedGainOnAvailableForSaleDebtSecuritiesToEarnings" id="cyrx_ReclassificationOfRealizedGainOnAvailableForSaleDebtSecuritiesToEarnings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PublicOfferingMember" id="cyrx_PublicOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NonCashNetUnrealizedGainLossOnAvailableForSaleSecurities" id="cyrx_NonCashNetUnrealizedGainLossOnAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="RealizedLossOnInvestmentsInEquitySecurities" id="cyrx_RealizedLossOnInvestmentsInEquitySecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="NumberOfCustomers" id="cyrx_NumberOfCustomers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FutureAmortizationOfFiniteLivedIntangibleAssets" id="cyrx_FutureAmortizationOfFiniteLivedIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ScheduleOfInterestExpensesOnConvertibleNotesPayableTableTextBlock" id="cyrx_ScheduleOfInterestExpensesOnConvertibleNotesPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioOneMember" id="cyrx_ScenarioOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioTwoMember" id="cyrx_ScenarioTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ThirdPartyOfferingRelatedCosts" id="cyrx_ThirdPartyOfferingRelatedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentRedemptionThresholdTradingDays" id="cyrx_DebtInstrumentRedemptionThresholdTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentRedemptionThresholdConsecutiveTradingDays" id="cyrx_DebtInstrumentRedemptionThresholdConsecutiveTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentRegistrationDefaultAdditionalInterestRate" id="cyrx_DebtInstrumentRegistrationDefaultAdditionalInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentRegistrationDefaultThresholdMaximumCombinedInterestRate" id="cyrx_DebtInstrumentRegistrationDefaultThresholdMaximumCombinedInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentRegistrationDefaultCashPaymentToEachNoteholderPercentage" id="cyrx_DebtInstrumentRegistrationDefaultCashPaymentToEachNoteholderPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ConvertibleSeniorNotesMember" id="cyrx_ConvertibleSeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" id="cyrx_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="InterestAmountOnAccountsPayableAndAccruedLiabilities" id="cyrx_InterestAmountOnAccountsPayableAndAccruedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ClassCConvertiblePreferredStockMember" id="cyrx_ClassCConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MveCryobiologicalStorageBusinessMember" id="cyrx_MveCryobiologicalStorageBusinessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CryopdpMember" id="cyrx_CryopdpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodAxis" id="cyrx_PreferredStockRedemptionPeriodAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodDomain" id="cyrx_PreferredStockRedemptionPeriodDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodOneMember" id="cyrx_PreferredStockRedemptionPeriodOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodTwoMember" id="cyrx_PreferredStockRedemptionPeriodTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodThreeMember" id="cyrx_PreferredStockRedemptionPeriodThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ReimbursementOfTransactionalExpenses" id="cyrx_ReimbursementOfTransactionalExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="NetProceedsFromIssuanceOfPrivatePlacement" id="cyrx_NetProceedsFromIssuanceOfPrivatePlacement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConvertibleConversionPricePerShare" id="cyrx_PreferredStockConvertibleConversionPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConvertibleConversionRate" id="cyrx_PreferredStockConvertibleConversionRate" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConvertibleThresholdTradingDays" id="cyrx_PreferredStockConvertibleThresholdTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConvertibleThresholdConsecutiveTradingDays" id="cyrx_PreferredStockConvertibleThresholdConsecutiveTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConvertibleStockPriceTriggerPercentage" id="cyrx_PreferredStockConvertibleStockPriceTriggerPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeemedDividend" id="cyrx_DeemedDividend" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockSharesToBeRedeemed" id="cyrx_PreferredStockSharesToBeRedeemed" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPricePercentage" id="cyrx_PreferredStockRedemptionPricePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockIfNotRepurchasedDividendRatePercentage" id="cyrx_PreferredStockIfNotRepurchasedDividendRatePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfBoardMemberWhoCanBeElectedByPreferredStockHolders" id="cyrx_NumberOfBoardMemberWhoCanBeElectedByPreferredStockHolders" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockOwnershipPercentageToExerciseRightToNominateBoard" id="cyrx_PreferredStockOwnershipPercentageToExerciseRightToNominateBoard" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredClassCMember" id="cyrx_PreferredClassCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FreezerMember" id="cyrx_FreezerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TruckAndAutoMember" id="cyrx_TruckAndAutoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfInstallments" id="cyrx_NumberOfInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NotesPayableTextBlock" id="cyrx_NotesPayableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AgentNetworkMember" id="cyrx_AgentNetworkMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PaidInKindDividendOnSeriesCConvertiblePreferredStockValue" id="cyrx_PaidInKindDividendOnSeriesCConvertiblePreferredStockValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PaidInKindDividendOnSeriesCConvertiblePreferredStocksValue" id="cyrx_PaidInKindDividendOnSeriesCConvertiblePreferredStocksValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="BusinessCombinationsAcquisitionCostsPolicyPolicyTextBlock" id="cyrx_BusinessCombinationsAcquisitionCostsPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalPaidInKindDividends" id="cyrx_AdjustmentsToAdditionalPaidInCapitalPaidInKindDividends" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="StatutoryCreditUsageLimitForResearchAndDevelopmentForTaxRelief" id="cyrx_StatutoryCreditUsageLimitForResearchAndDevelopmentForTaxRelief" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="TaxExaminationPeriodForForeignSubsidiaries" id="cyrx_TaxExaminationPeriodForForeignSubsidiaries" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalConversionCosts" id="cyrx_AdjustmentsToAdditionalPaidInCapitalConversionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CostOfSeriesCPreferredStockConversionIncludedInAdditionalPaidInCapitalAndAccountsPayableAndAccruedLiabilities" id="cyrx_CostOfSeriesCPreferredStockConversionIncludedInAdditionalPaidInCapitalAndAccountsPayableAndAccruedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="GoodwillAdjustmentIncludedInDeferredTaxLiability" id="cyrx_GoodwillAdjustmentIncludedInDeferredTaxLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="GoodwillAdjustmentIncludedInFixedAssets" id="cyrx_GoodwillAdjustmentIncludedInFixedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="NoteValuationAdjustmentIncludedInNotePayableAndGoodwill" id="cyrx_NoteValuationAdjustmentIncludedInNotePayableAndGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConvertibleConversionCost" id="cyrx_PreferredStockConvertibleConversionCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="AcquireeWorkingCapitalSettlementIncludedInGoodwillAndAccountsPayable" id="cyrx_AcquireeWorkingCapitalSettlementIncludedInGoodwillAndAccountsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CriticalTransportSolutionsAustraliaAndFairgateMember" id="cyrx_CriticalTransportSolutionsAustraliaAndFairgateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BusinessCombinationContingentConsiderationLiabilityFairValueDisclosure" id="cyrx_BusinessCombinationContingentConsiderationLiabilityFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="FirstInstallmentRepayableNoLaterThanDecember312021Member" id="cyrx_FirstInstallmentRepayableNoLaterThanDecember312021Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SecondInstallmentRepayableNoLaterThanDecember312022Member" id="cyrx_SecondInstallmentRepayableNoLaterThanDecember312022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedButUnissued" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedButUnissued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ThresholdUsedForCalculatingConcentrationOfRisk" id="cyrx_ThresholdUsedForCalculatingConcentrationOfRisk" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CustomerMember" id="cyrx_CustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CostOfServicesRevenuesPolicyTextBlock" id="cyrx_CostOfServicesRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CostOfProductRevenuesPolicyTextBlock" id="cyrx_CostOfProductRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BusinessCombinationPriorPeriodAdjustmentDeferredTax" id="cyrx_BusinessCombinationPriorPeriodAdjustmentDeferredTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="SeniorNotes2025Member" id="cyrx_SeniorNotes2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SeniorNotes2026Member" id="cyrx_SeniorNotes2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashRepurchasePrise" id="cyrx_CashRepurchasePrise" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="LossOnExtinguishmentOfDebt" id="cyrx_LossOnExtinguishmentOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="TotalRemainingPrincipalAmountOutstanding" id="cyrx_TotalRemainingPrincipalAmountOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ExclusiveRightOfNoteholdersMaximumPercentageOfSpecialInterestOnPrincipalAmount" id="cyrx_ExclusiveRightOfNoteholdersMaximumPercentageOfSpecialInterestOnPrincipalAmount" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ExclusiveRightOfNoteholdersMaximumNumberOfDaysToReceiveSpecialInterestOnSeniorNotes" id="cyrx_ExclusiveRightOfNoteholdersMaximumNumberOfDaysToReceiveSpecialInterestOnSeniorNotes" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MveBiologicalSolutionsMember" id="cyrx_MveBiologicalSolutionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentConvertibleConversionPrice" id="cyrx_DebtInstrumentConvertibleConversionPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="DebtInstrumentConvertibleThresholdMaximumConversionRatio" id="cyrx_DebtInstrumentConvertibleThresholdMaximumConversionRatio" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccumulatedOtherComprehensiveIncomeLoss" id="cyrx_AccumulatedOtherComprehensiveIncomeLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ConcurrentPlacementMember" id="cyrx_ConcurrentPlacementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentRedemptionPrincipalAmountRedeemed" id="cyrx_DebtInstrumentRedemptionPrincipalAmountRedeemed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="NetProceedsAfterDeductingBankerFeesToBeUsedForGeneralCorporatePurposes" id="cyrx_NetProceedsAfterDeductingBankerFeesToBeUsedForGeneralCorporatePurposes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardWeightedaverageFairvalueperShares" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardWeightedaverageFairvalueperShares" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CellCoBioservicesMember" id="cyrx_CellCoBioservicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PaymentsForProceedsFromInsuranceProceedsForLossFromFixedAssets" id="cyrx_PaymentsForProceedsFromInsuranceProceedsForLossFromFixedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CurrentPortionOfOperatingLeaseLiability" id="cyrx_CurrentPortionOfOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NonCurrentPortionOfOperatingLeaseLiability" id="cyrx_NonCurrentPortionOfOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RevenuePracticalExpedientRemainingPerformanceObligation." id="cyrx_RevenuePracticalExpedientRemainingPerformanceObligation." type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PaymentsToAcquireCellAndCo" id="cyrx_PaymentsToAcquireCellAndCo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PaymentsToAcquireCtsaAndFairGate" id="cyrx_PaymentsToAcquireCtsaAndFairGate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfInterestExpenseOnNotesPayableTableTextBlock" id="cyrx_ScheduleOfInterestExpenseOnNotesPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NotesPayableMember" id="cyrx_NotesPayableMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NotesPayableMaturingOnJuly2027Member" id="cyrx_NotesPayableMaturingOnJuly2027Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NotesPayableMaturingOnJuly2030Member" id="cyrx_NotesPayableMaturingOnJuly2030Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PolarExpressMadridSpainMember" id="cyrx_PolarExpressMadridSpainMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CellMattersBasedInLiegeBelgiumMember" id="cyrx_CellMattersBasedInLiegeBelgiumMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NonCashActivityOfCommonStockIssuedForCellCoAcquisition" id="cyrx_NonCashActivityOfCommonStockIssuedForCellCoAcquisition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationConsiderationUpfrontFees" id="cyrx_BusinessCombinationConsiderationUpfrontFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationAcquisitionEquityInterestSharesIssuable" id="cyrx_BusinessCombinationAcquisitionEquityInterestSharesIssuable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ExcessAndObsoleteInventory" id="cyrx_ExcessAndObsoleteInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
