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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash Flows From Operating Activities: |  |  |
Net loss | $ (37,333) | $ (275,528) | $ (32,693)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Loss on extinguishment of debt |  | 251,754 | 0
Depreciation and amortization | 22,765 | 20,247 | 9,869
Amortization of debt discount | 2,581 | 1,236 | 437
Unrealized (gain) loss on investments in equity securities | 11,406 | 1,386 | (845)
Realized loss on investments in equity securities |  | 0 | 1,090
Realized (gain) loss on available-for-sale debt securities | 102 | 81 | 32
Stock-based compensation expense | 20,082 | 15,345 | 8,916
Loss on disposal of property and equipment | 800 | 542 | 384
Excess and obsolete inventory | 651 | 0 | 0
Gain on insurance settlement | (4,815) | 0 | 0
Insurance proceeds for operations | 9,883 | 0 | 0
Provision for bad debt | 234 | 26 | 197
Change in contingent consideration | 216 | 0 | 0
Changes in operating assets and liabilities, net of effects of acquisition: |  |  |
Accounts receivable | (4,137) | (7,270) | (2,617)
Inventories | (14,204) | (5,979) | 1,322
Prepaid expenses and other current assets | (1,598) | 3,056 | (7,520)
Deposits | (60) | 211 | (152)
Change in operating lease right-of-use assets and lease liabilities | 569 | 562 | 134
Accounts payable and other accrued expenses | (6,483) | (398) | 4,245
Accrued compensation and related expenses | (1,569) | 2,522 | 3,143
Deferred revenue | (530) | 102 | (309)
Net deferred tax (asset) liability | (411) | 231 | (499)
Net cash provided by (used in) operating activities | (1,851) | 8,126 | (14,866)
Cash Flows From Investing Activities: |  |  |
Purchases of property and equipment | (22,107) | (23,882) | (8,918)
Insurance proceeds for loss of fixed assets | 3,000 | 0 | 0
Purchases of short-term investments | (163,788) | (482,707) | (158,736)
Sales/maturities of short-term investments | 131,858 | 44,000 | 149,233
Patent and trademark costs | (614) | (255) | (200)
Software development costs | (1,476) | (870) | (551)
Cash paid for acquisitions | 6,554 | 5,540 | 363,140
Net cash used in investing activities | (59,681) | (469,254) | (382,312)
Cash Flows From Financing Activities: |  |  |
Proceeds from exercise of stock options and warrants | 2,048 | 8,995 | 9,388
Repurchase of common stock | (37,960) | 0 | 0
Proceeds from issuance of Series C convertible preferred stock, net of issuance costs |  | 248,911 | 237,225
Proceeds from issuance of common stock, net of issuance costs |  | 0 | 28,160
Proceeds from public offering, net of offering costs |  | 269,825 | 0
Repayment of finance lease liabilities | (82) | (60) | (70)
Repayment of note payable | (3,180) | (3,397) | 0
Proceeds from issuance of convertible senior notes |  | 40,068 | 115,000
Payment of deferred financing costs |  | 0 | (4,118)
Net cash provided by (used in) financing activities | (39,174) | 564,342 | 385,585
Effect of exchange rate changes on cash and cash equivalents | (1,800) | (986) | 1,231
Net change in cash and cash equivalents | (102,506) | 102,228 | (10,362)
Cash and cash equivalents - beginning of year | 139,101 | 36,873 | 47,235
Cash and cash equivalents - end of year | 36,595 | 139,101 | 36,873
Supplemental Disclosure of Cash Flow Information: |  |  |
Cash paid for interest | 3,628 | 3,297 | 1,823
Cash paid for income taxes | 1,979 | 1,315 | 60
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |  |  |
Net unrealized gain (loss) on available-for-sale debt securities | 23,439 | 3,958 | 161
Reclassification of realized gain on available-for-sale debt securities to earnings | 46 | 27 | 3
Fixed assets included in accounts payable and accrued liabilities | 1,003 | 1,412 | 499
Purchase of equipment through finance lease obligations |  | 0 | 205
Paid-in-kind preferred stock dividend, including beneficial conversion feature | $ 8,000 | 8,196 | 2,844
Common stock issued for conversion of debt and accrued interest |  | $ 765 | $ 0

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- Definition The cash outflow for a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3291-108585 + Details
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