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  <xsd:element name="Plan2018Member" id="cyrx_Plan2018Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NatureOfBusinessAbstract" id="cyrx_NatureOfBusinessAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PatentsAndTrademarksMember" id="cyrx_PatentsAndTrademarksMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ReclassificationOfRealizedGainOnAvailableForSaleDebtSecuritiesToEarnings" id="cyrx_ReclassificationOfRealizedGainOnAvailableForSaleDebtSecuritiesToEarnings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="NonCashNetUnrealizedGainLossOnAvailableForSaleSecurities" id="cyrx_NonCashNetUnrealizedGainLossOnAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="FutureAmortizationOfFiniteLivedIntangibleAssets" id="cyrx_FutureAmortizationOfFiniteLivedIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ScheduleOfInterestExpensesOnConvertibleNotesPayableTableTextBlock" id="cyrx_ScheduleOfInterestExpensesOnConvertibleNotesPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" id="cyrx_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ClassCConvertiblePreferredStockMember" id="cyrx_ClassCConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodAxis" id="cyrx_PreferredStockRedemptionPeriodAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockRedemptionPeriodDomain" id="cyrx_PreferredStockRedemptionPeriodDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredClassCMember" id="cyrx_PreferredClassCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PaidInKindDividendOnSeriesCConvertiblePreferredStockValue" id="cyrx_PaidInKindDividendOnSeriesCConvertiblePreferredStockValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PaidInKindDividendOnSeriesCConvertiblePreferredStocksValue" id="cyrx_PaidInKindDividendOnSeriesCConvertiblePreferredStocksValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SeniorNotes2025Member" id="cyrx_SeniorNotes2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SeniorNotes2026Member" id="cyrx_SeniorNotes2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PurchaseOfEquipmentThroughCapitalLeaseObligation" id="cyrx_PurchaseOfEquipmentThroughCapitalLeaseObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ExcessAndObsoleteInventory" id="cyrx_ExcessAndObsoleteInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" id="cyrx_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ContractWithCustomerLiabilityRevenueRecognizedExcludingOpeningBalance" id="cyrx_ContractWithCustomerLiabilityRevenueRecognizedExcludingOpeningBalance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RightOfUseAssetObtainedInExchangeForLeaseObligationsAbstract" id="cyrx_RightOfUseAssetObtainedInExchangeForLeaseObligationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardWeightedAverageFairValuePerShares" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardWeightedAverageFairValuePerShares" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentConsiderationMember" id="cyrx_ContingentConsiderationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PeriodOfContingentConsiderationPayable" id="cyrx_PeriodOfContingentConsiderationPayable" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="MaximumContingentConsiderationPayableInCash" id="cyrx_MaximumContingentConsiderationPayableInCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="Acquisitions2021Member" id="cyrx_Acquisitions2021Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Acquisitions2022Member" id="cyrx_Acquisitions2022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AvailableForSaleSecuritiesUnrealizedLossPositionFairValue" id="cyrx_AvailableForSaleSecuritiesUnrealizedLossPositionFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AvailableForSaleSecuritiesUnrealizedLossPositionTwelveMonthsOrLongerFairValue" id="cyrx_AvailableForSaleSecuritiesUnrealizedLossPositionTwelveMonthsOrLongerFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OperatingLeaseRightOfUseAssetsAndLeaseLiabilities" id="cyrx_OperatingLeaseRightOfUseAssetsAndLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PaidInKindPreferredStockDividendIncludingBeneficialConversionFeature" id="cyrx_PaidInKindPreferredStockDividendIncludingBeneficialConversionFeature" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RevenueConcentrationsAndGeographicInformationTextBlock" id="cyrx_RevenueConcentrationsAndGeographicInformationTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RevenueConcentrationsAndGeographicInformationAbstract" id="cyrx_RevenueConcentrationsAndGeographicInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RevenueConcentrationsAndGeographicInformationTable" id="cyrx_RevenueConcentrationsAndGeographicInformationTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RevenueConcentrationsAndGeographicInformationLineItems" id="cyrx_RevenueConcentrationsAndGeographicInformationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConversionOf2026SeniorNotesMember" id="cyrx_ConversionOf2026SeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConversionOf2025SeniorNotesMember" id="cyrx_ConversionOf2025SeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Acquisitions2023Member" id="cyrx_Acquisitions2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncreaseDecreaseInCreditLosses" id="cyrx_IncreaseDecreaseInCreditLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BiologisticsSolutionsMember" id="cyrx_BiologisticsSolutionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BiostorageBioservicesMember" id="cyrx_BiostorageBioservicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="JerrellW.SheltonMember" id="cyrx_JerrellW.SheltonMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RamkumarMandalamMember" id="cyrx_RamkumarMandalamMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PurchaseOfStockArrangementMember" id="cyrx_PurchaseOfStockArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExerciseOfStockOptionsArrangementMember" id="cyrx_ExerciseOfStockOptionsArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FiniteLivedIntangibleAssetsAccumulatedImpairment" id="cyrx_FiniteLivedIntangibleAssetsAccumulatedImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockAndDebtRepurchaseProgramAuthorizedAmount" id="cyrx_StockAndDebtRepurchaseProgramAuthorizedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockAndDebtRepurchaseProgramRemainingAuthorizedRepurchaseAmount" id="cyrx_StockAndDebtRepurchaseProgramRemainingAuthorizedRepurchaseAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RepurchaseProgramAxis" id="cyrx_RepurchaseProgramAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RepurchaseProgramDomain" id="cyrx_RepurchaseProgramDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RepurchaseProgram2022Member" id="cyrx_RepurchaseProgram2022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RepurchaseProgram2024Member" id="cyrx_RepurchaseProgram2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleSubordinatedDebtCurrentDiscount" id="cyrx_ConvertibleSubordinatedDebtCurrentDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ConvertibleSubordinatedDebtNoncurrentDiscount" id="cyrx_ConvertibleSubordinatedDebtNoncurrentDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RepurchaseProgramsMember" id="cyrx_RepurchaseProgramsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LifeScienceSupplyChainSolutionsSegmentMember" id="cyrx_LifeScienceSupplyChainSolutionsSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LifeScienceSystemsSegmentMember" id="cyrx_LifeScienceSystemsSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationAcquisitionAndIntegrationRelatedCosts" id="cyrx_BusinessCombinationAcquisitionAndIntegrationRelatedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RentExpenses" id="cyrx_RentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OverheadExpenses" id="cyrx_OverheadExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustedEarningsBeforeInterestTaxDepreciationAndAmortization" id="cyrx_AdjustedEarningsBeforeInterestTaxDepreciationAndAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifications" id="cyrx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifications" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignCurrencyAdjustments" id="cyrx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignCurrencyAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CostOfGoodsAndServicesSoldExcludingRentCompensationAndDepreciationAndAmortization" id="cyrx_CostOfGoodsAndServicesSoldExcludingRentCompensationAndDepreciationAndAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ResearchAndDevelopmentExpenseExcludingCompensationAndDepreciationAndAmortization" id="cyrx_ResearchAndDevelopmentExpenseExcludingCompensationAndDepreciationAndAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CostStockBasedCompensation" id="cyrx_CostStockBasedCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ResearchAndDevelopmentEmployeeRelatedExpense" id="cyrx_ResearchAndDevelopmentEmployeeRelatedExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ResearchAndDevelopmentStockBasedCompensationExpense" id="cyrx_ResearchAndDevelopmentStockBasedCompensationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ResearchAndDevelopmentDepreciationDepletionAndAmortizationExpense" id="cyrx_ResearchAndDevelopmentDepreciationDepletionAndAmortizationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CryopdpSpecialtyCourierBusinessMember" id="cyrx_CryopdpSpecialtyCourierBusinessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOperatingLeaseRightOfUseAssets" id="cyrx_DisposalGroupIncludingDiscontinuedOperationOperatingLeaseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationAccountsPayableAndOtherAccruedLiabilitiesCurrent" id="cyrx_DisposalGroupIncludingDiscontinuedOperationAccountsPayableAndOtherAccruedLiabilitiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationAccruedCompensationAndRelatedExpensesCurrent" id="cyrx_DisposalGroupIncludingDiscontinuedOperationAccruedCompensationAndRelatedExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOperatingLeaseLiabilityCurrent" id="cyrx_DisposalGroupIncludingDiscontinuedOperationOperatingLeaseLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent" id="cyrx_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOperatingLeaseLiabilityNoncurrent" id="cyrx_DisposalGroupIncludingDiscontinuedOperationOperatingLeaseLiabilityNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityNoncurrent" id="cyrx_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationSellingGeneralAndAdministrativeExpense" id="cyrx_DisposalGroupIncludingDiscontinuedOperationSellingGeneralAndAdministrativeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NetOperatingCashProvidedByUsedInDiscontinuedOperationsAbstract" id="cyrx_NetOperatingCashProvidedByUsedInDiscontinuedOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DiscontinuedOperationStockBasedCompensationExpense" id="cyrx_DiscontinuedOperationStockBasedCompensationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DiscontinuedOperationNonCashOperatingLeaseExpense" id="cyrx_DiscontinuedOperationNonCashOperatingLeaseExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NetInvestingCashProvidedByUsedInDiscontinuedOperationsAbstract" id="cyrx_NetInvestingCashProvidedByUsedInDiscontinuedOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DiscontinuedOperationCapitalExpenditurePurchasesOfPropertyAndEquipment" id="cyrx_DiscontinuedOperationCapitalExpenditurePurchasesOfPropertyAndEquipment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DiscontinuedOperationCapitalExpenditureSoftwareDevelopmentCosts" id="cyrx_DiscontinuedOperationCapitalExpenditureSoftwareDevelopmentCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationsCashConsiderationReceivable" id="cyrx_DisposalGroupIncludingDiscontinuedOperationsCashConsiderationReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IntercompanyLoansReceivableOutstanding" id="cyrx_IntercompanyLoansReceivableOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationsConsiderationReceivableNetDebtOwed" id="cyrx_DisposalGroupIncludingDiscontinuedOperationsConsiderationReceivableNetDebtOwed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ContingentConsiderationReclassifiedToAccountsPayableAndAccruedLiabilities" id="cyrx_ContingentConsiderationReclassifiedToAccountsPayableAndAccruedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationRevenueAbstract" id="cyrx_DisposalGroupIncludingDiscontinuedOperationRevenueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DivestitureCosts" id="cyrx_DivestitureCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
