<SEC-DOCUMENT>0001752724-20-037929.txt : 20200227
<SEC-HEADER>0001752724-20-037929.hdr.sgml : 20200227
<ACCEPTANCE-DATETIME>20200226210217
ACCESSION NUMBER:		0001752724-20-037929
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20191231
FILED AS OF DATE:		20200227
PERIOD START:           	20191231

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BlackRock Health Sciences Trust
		CENTRAL INDEX KEY:			0001314966
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-21702
		FILM NUMBER:		20658102

	BUSINESS ADDRESS:	
		STREET 1:		100 BELLEVUE PARKWAY
		CITY:			WILMINGTON
		STATE:			DE
		ZIP:			19809
		BUSINESS PHONE:		(888) 825-2257

	MAIL ADDRESS:	
		STREET 1:		100 BELLEVUE PARKWAY
		CITY:			WILMINGTON
		STATE:			DE
		ZIP:			19809
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <regFileNumber>811-21702</regFileNumber>
      <regCik>0001314966</regCik>
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      <regStreet1>100 BELLEVUE PARKWAY</regStreet1>
      <regCity>WILMINGTON</regCity>
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      <regZipOrPostalCode>19809</regZipOrPostalCode>
      <regPhone>800-441-7762</regPhone>
      <seriesName>BlackRock Health Sciences Trust</seriesName>
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      <repPdEnd>2019-12-31</repPdEnd>
      <repPdDate>2019-12-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
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      <totLiabs>10964968.61</totLiabs>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>Envista Holdings Corp</name>
        <lei>549300BX623VURJZ5269</lei>
        <title>Envista Holdings Corp</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>BLUEPRINT MEDICINES CORP JAN20 85 CALL</title>
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        <fairValLevel>1</fairValLevel>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <unrealizedAppr>-940.28</unrealizedAppr>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <unrealizedAppr>-33261.23</unrealizedAppr>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>GILEAD SCIENCES INC JAN20 67.5 CALL</title>
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            <unrealizedAppr>3042.33</unrealizedAppr>
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      <invstOrSec>
        <name>Zoetis Inc</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>Zoetis Inc</title>
        <cusip>98978V103</cusip>
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        <balance>89614.00000000</balance>
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      <invstOrSec>
        <name>SUSQUEHANNA FINANCIAL GROUP LLLP</name>
        <lei>549300E8QX0ZMRDC2M81</lei>
        <title>BRTZ3B5C3 JAN20 PFE US CALL JAN20 38.7 CALL</title>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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      <invstOrSec>
        <name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</name>
        <lei>8NAV47T0Y26Q87Y0QP81</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>PFIZER INC JAN20 38 CALL</title>
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        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>JP MORGAN CHASE BANK</name>
        <lei>7H6GLXDRUGQFU57RNE97</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>Options Clearing Corp.</name>
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        <name>HCA Healthcare Inc</name>
        <lei>N/A</lei>
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        <name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</name>
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                <issuerName>Zimmer Biomet Holdings Inc</issuerName>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>CREDIT SUISSE INTERNATIONAL</name>
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        <lei>8MYN82XMYQH89CTMTH67</lei>
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        <name>Options Clearing Corp.</name>
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        <name>Corbus Pharmaceuticals Holdings Inc</name>
        <lei>529900MX6XCNZC7MM155</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Teleflex Inc</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>Teleflex Inc</title>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>JP MORGAN CHASE BANK</name>
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        <name>Options Clearing Corp.</name>
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        <name>QIAGEN NV</name>
        <lei>54930036WK3GMCN17Z57</lei>
        <title>QIAGEN NV</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Daiichi Sankyo Co Ltd</name>
        <lei>353800XGIU2IHQGC9504</lei>
        <title>Daiichi Sankyo Co Ltd</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MyoKardia Inc</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MyoKardia Inc</title>
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        <balance>17691.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1289408.54000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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          <other otherDesc="BlackRock Identifier" value="Z94FX28C2"/>
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        <balance>-36.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-69660.00000000</valUSD>
        <pctVal>-0.01560573028</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <optionSwaptionWarrantDeriv derivCat="OPT">
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
              <counterpartyLei>549300CII6SLYGKNHA04</counterpartyLei>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
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                <issuerName>Intuitive Surgical Inc</issuerName>
                <issueTitle>Intuitive Surgical Inc</issueTitle>
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                  <cusip value="46120E602"/>
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            </descRefInstrmnt>
            <shareNo>100.00000000</shareNo>
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            <delta>XXXX</delta>
            <unrealizedAppr>10371.74</unrealizedAppr>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Atreca Inc</name>
        <lei>549300B5CQV1OOXFLU71</lei>
        <title>Atreca Inc</title>
        <cusip>04965G109</cusip>
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          <isin value="US04965G1094"/>
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        <balance>19203.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>297070.41000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>CENTENE CORP JAN20 57.5 CALL</title>
        <cusip>000000000</cusip>
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          <other otherDesc="BlackRock Identifier" value="Z947PQU64"/>
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        <balance>-174.00000000</balance>
        <units>NC</units>
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        <valUSD>-97440.00000000</valUSD>
        <pctVal>-0.02182920412</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
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                <issuerName>Centene Corp</issuerName>
                <issueTitle>Centene Corp</issueTitle>
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            <shareNo>100.00000000</shareNo>
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            <delta>XXXX</delta>
            <unrealizedAppr>-68240.92</unrealizedAppr>
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      <invstOrSec>
        <name>Teladoc Health Inc</name>
        <lei>549300I2PVFBC9MFAC61</lei>
        <title>Teladoc Health Inc</title>
        <cusip>87918A105</cusip>
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          <isin value="US87918A1051"/>
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        <balance>36070.00000000</balance>
        <units>NS</units>
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        <valUSD>3019780.40000000</valUSD>
        <pctVal>0.676512754128</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Ra Pharmaceuticals Inc</name>
        <lei>549300JE4B54MQ4MWX95</lei>
        <title>Ra Pharmaceuticals Inc</title>
        <cusip>74933V108</cusip>
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          <isin value="US74933V1089"/>
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        <balance>45620.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2140946.60000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ZOETIS INC JAN20 125 CALL</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="BlackRock Identifier" value="Z92PNRG96"/>
        </identifiers>
        <balance>-73.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-56210.00000000</valUSD>
        <pctVal>-0.01259256531</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
              <counterpartyLei>549300CII6SLYGKNHA04</counterpartyLei>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
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                <issuerName>Zoetis Inc</issuerName>
                <issueTitle>Zoetis Inc</issueTitle>
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            </descRefInstrmnt>
            <shareNo>100.00000000</shareNo>
            <exercisePrice>125</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2020-01-17</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-48134.69</unrealizedAppr>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</name>
        <lei>8NAV47T0Y26Q87Y0QP81</lei>
        <title>BRTZB5016 JAN20 PFE US CALL JAN20 38.48 CALL</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="BlackRock Identifier" value="BRTZB5016"/>
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        <balance>-127.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-13531.98000000</valUSD>
        <pctVal>-0.00303153072</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
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              <counterpartyName>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</counterpartyName>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
            <descRefInstrmnt>
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                <issuerName>Pfizer Inc</issuerName>
                <issueTitle>Pfizer Inc</issueTitle>
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                  <cusip value="717081103"/>
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              </otherRefInst>
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            <shareNo>100.00000000</shareNo>
            <exercisePrice>38.48</exercisePrice>
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            <expDt>2020-01-31</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>153.4</unrealizedAppr>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ZOETIS INC JAN20 128 CALL</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="BlackRock Identifier" value="Z94FT46X9"/>
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        <balance>-100.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-57500.00000000</valUSD>
        <pctVal>-0.01288156031</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
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                <issuerName>Zoetis Inc</issuerName>
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            <shareNo>100.00000000</shareNo>
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            <expDt>2020-01-24</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-45524.14</unrealizedAppr>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>JP MORGAN CHASE BANK</name>
        <lei>7H6GLXDRUGQFU57RNE97</lei>
        <title>BRTZC0CQ8 JAN20 3692 HK CALL JAN20 24.2793 CALL</title>
        <cusip>000000000</cusip>
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          <other otherDesc="BlackRock Identifier" value="BRTZC0CQ8"/>
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        <balance>-324000.00000000</balance>
        <units>NC</units>
        <currencyConditional curCd="HKD" exchangeRt="7.79230000"/>
        <valUSD>-79143.60000000</valUSD>
        <pctVal>-0.01773031403</pctVal>
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        <assetCat>DE</assetCat>
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        <invCountry>HK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
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              <counterpartyName>JP MORGAN CHASE BANK</counterpartyName>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
            <descRefInstrmnt>
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                <issuerName>Hansoh Pharmaceutical Group Co Ltd</issuerName>
                <issueTitle>Hansoh Pharmaceutical Group Co Ltd</issueTitle>
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                  <isin value="KYG549581067"/>
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            <shareNo>1.00000000</shareNo>
            <exercisePrice>24.2793</exercisePrice>
            <exercisePriceCurCd>HKD</exercisePriceCurCd>
            <expDt>2020-01-14</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-55602.54</unrealizedAppr>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SUSQUEHANNA FINANCIAL GROUP LLLP</name>
        <lei>549300E8QX0ZMRDC2M81</lei>
        <title>BRTYUGMK8 JAN20 BMY US CALL JAN20 58.6 CALL</title>
        <cusip>000000000</cusip>
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          <other otherDesc="BlackRock Identifier" value="BRTYUGMK8"/>
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        <balance>-131.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-67685.21000000</valUSD>
        <pctVal>-0.01516332374</pctVal>
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        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

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              <counterpartyName>SUSQUEHANNA FINANCIAL GROUP LLLP</counterpartyName>
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                <issuerName>Bristol-Myers Squibb Co</issuerName>
                <issueTitle>Bristol-Myers Squibb Co</issueTitle>
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                  <isin value="US1101221083"/>
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            <shareNo>100.00000000</shareNo>
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            <expDt>2020-01-10</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-51603.83</unrealizedAppr>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ILLUMINA INC JAN20 320 CALL</title>
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          <other otherDesc="BlackRock Identifier" value="Z92HDVT84"/>
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        <balance>-10.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-18750.00000000</valUSD>
        <pctVal>-0.00420050879</pctVal>
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        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <putOrCall>Call</putOrCall>
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                <issuerName>Illumina Inc</issuerName>
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                  <isin value="US4523271090"/>
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            <shareNo>100.00000000</shareNo>
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            <expDt>2020-01-17</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-8560.11</unrealizedAppr>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>MEDTRONIC PLC JAN20 115 CALL</title>
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          <other otherDesc="BlackRock Identifier" value="Z94FLQ147"/>
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        <balance>-117.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-6376.50000000</valUSD>
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        <assetCat>DE</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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                <issuerName>Medtronic PLC</issuerName>
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            <shareNo>100.00000000</shareNo>
            <exercisePrice>115</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2020-01-10</expDt>
            <delta>XXXX</delta>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Urovant Sciences Ltd</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>Avantor Inc</name>
        <lei>5493003VM0XB4U8YD238</lei>
        <title>Avantor Inc</title>
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        <name>Options Clearing Corp.</name>
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        <name>NextCure Inc</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>MORGAN STANLEY &amp; CO. INTERNATIONAL</name>
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        <name>JEFFERIES LLC</name>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>WuXi AppTec Co Ltd</name>
        <lei>254900OEPQLZSPLN9175</lei>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Stryker Corp</name>
        <lei>5493002F0SC4JTBU5137</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>MORGAN STANLEY &amp; CO. INTERNATIONAL</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <unrealizedAppr>-8249.41</unrealizedAppr>
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      <invstOrSec>
        <name>Reata Pharmaceuticals Inc</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>Reata Pharmaceuticals Inc</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ABBOTT LABORATORIES JAN20 88 CALL</title>
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                <issuerName>Abbott Laboratories</issuerName>
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        <name>Pfizer Inc</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>Centene Corp</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>Centene Corp</title>
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        <name>Agilent Technologies Inc</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
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        <name>GOLDMAN SACHS &amp; CO. LLC</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>Apellis Pharmaceuticals Inc</name>
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        <name>Syndax Pharmaceuticals Inc</name>
        <lei>529900OF94TRHKZVBS87</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>Baxter International Inc</name>
        <lei>J5OIVXX3P24RJRW5CK77</lei>
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        <name>Incyte Corp</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>VARIAN MEDICAL SYSTEMS INC JAN20 135 CALL</title>
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        <name>JP MORGAN CHASE BANK</name>
        <lei>7H6GLXDRUGQFU57RNE97</lei>
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                <issuerName>Sanofi</issuerName>
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        <name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</name>
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        <name>Merck KGaA</name>
        <lei>529900OAREIS0MOPTW25</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>Options Clearing Corp.</name>
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        <name>Galapagos NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>Galapagos NV</title>
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        <name>Halozyme Therapeutics Inc</name>
        <lei>529900242I3SV9AGM753</lei>
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        <name>Guardant Health Inc</name>
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        <name>BARCLAYS BANK PLC</name>
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        <name>Principia Biopharma Inc</name>
        <lei>549300WHPKRLU16IRE69</lei>
        <title>Principia Biopharma Inc</title>
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        <name>MORGAN STANLEY &amp; CO LLC</name>
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        <title>BRW023WA9 JAN20 GSK LN C JAN20 17.7645 CALL</title>
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        <name>ABIOMED Inc</name>
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        <name>Humana Inc</name>
        <lei>529900YLDW34GJAO4J06</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>Mirati Therapeutics Inc</name>
        <lei>529900GYRW59IDQV6N54</lei>
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        <name>Hua Medicine</name>
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        <title>Hua Medicine</title>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>GOLDMAN SACHS INTERNATIONAL</name>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BioMarin Pharmaceutical Inc</title>
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        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>UnitedHealth Group Inc</name>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics Inc</title>
        <cusip>803607100</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ALNYLAM PHARMACEUTICALS INC JAN20 95 CALL</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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            <unrealizedAppr>-116177.89</unrealizedAppr>
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        <name>ResMed Inc</name>
        <lei>254900Q4WEDMZBOZ0002</lei>
        <title>ResMed Inc</title>
        <cusip>761152107</cusip>
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          <isin value="US7611521078"/>
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        <balance>26094.00000000</balance>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Genmab A/S</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>GENMAB A/S  SP ADR ADR</title>
        <cusip>372303206</cusip>
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          <isin value="US3723032062"/>
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        <balance>38411.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>857717.63000000</valUSD>
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        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ACADIA PHARMACEUTICALS INC JAN20 49 CALL</title>
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            <shareNo>100.00000000</shareNo>
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      <invstOrSec>
        <name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</name>
        <lei>8NAV47T0Y26Q87Y0QP81</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>MASIMO CORP JAN20 160 CALL</title>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>QIAGEN NV JAN20 40 CALL</title>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ALLAKOS INC FEB20 135 CALL</title>
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        <isRestrictedSec>N</isRestrictedSec>

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                <issuerName>Allakos Inc</issuerName>
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            <unrealizedAppr>65274.36</unrealizedAppr>
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        <name>Options Clearing Corp.</name>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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        <name>Options Clearing Corp.</name>
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        <name>Merck &amp; Co Inc</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>MORGAN STANLEY &amp; CO LLC</name>
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        <name>Amgen Inc</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
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        <name>Allogene Therapeutics Inc</name>
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        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences Inc</title>
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        <name>Acceleron Pharma Inc</name>
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        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Alexion Pharmaceuticals Inc</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>Options Clearing Corp.</name>
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        <name>Genmab A/S</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <name>Money Market Series a series of SL Liquidity Series, LLC</name>
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        <title>SL Liquidity Series, LLC, Money Market Series</title>
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        <fairValLevel>N/A</fairValLevel>
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        <name>Intuitive Surgical Inc</name>
        <lei>54930052SRG011710797</lei>
        <title>Intuitive Surgical Inc</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>MERCK + CO INC JAN20 92 CALL</title>
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        <valUSD>-22487.00000000</valUSD>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>INTUITIVE SURGICAL INC JAN20 600 CALL</title>
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        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>RESMED INC FEB20 155 CALL</title>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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            <unrealizedAppr>-482.26</unrealizedAppr>
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      <invstOrSec>
        <name>UBS AG</name>
        <lei>BFM8T61CT2L1QCEMIK50</lei>
        <title>BRW0AU6Q4 FEB20 BMRN US CALL FEB20 85.565 CALL</title>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>Eisai Co Ltd</name>
        <lei>N/A</lei>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
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        <isRestrictedSec>N</isRestrictedSec>

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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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      <invstOrSec>
        <name>Becton Dickinson and Co</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
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        <curCd>USD</curCd>
        <valUSD>-45987.50000000</valUSD>
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        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <putOrCall>Call</putOrCall>
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                <issuerName>Cigna Corp</issuerName>
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            <shareNo>100.00000000</shareNo>
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            <unrealizedAppr>9799.28</unrealizedAppr>
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      <invstOrSec>
        <name>Barclays Capital Securities Limited</name>
        <lei>K9WDOH4D2PYBSLSOB484</lei>
        <title>BRW066DF8 JAN20 SYK US CALL JAN20 205.479 CALL</title>
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        <curCd>USD</curCd>
        <valUSD>-78678.86000000</valUSD>
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        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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              <counterpartyName>Barclays Capital Securities Limited</counterpartyName>
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                <issuerName>Stryker Corp</issuerName>
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            <shareNo>1.00000000</shareNo>
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            <delta>XXXX</delta>
            <unrealizedAppr>-40645.1</unrealizedAppr>
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      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
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        <balance>73387.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>GOLDMAN SACHS &amp; CO. LLC</name>
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        <balance>-7000.00000000</balance>
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        <currencyConditional curCd="EUR" exchangeRt="0.89150400"/>
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        <pctVal>-0.00187087077</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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                <issuerName>Merck KGaA</issuerName>
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            <shareNo>1.00000000</shareNo>
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            <unrealizedAppr>58.12</unrealizedAppr>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>ACCELERON PHARMA INC JAN20 50 CALL</title>
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          <other otherDesc="BlackRock Identifier" value="Z94CFJW35"/>
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        <balance>-43.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-20102.50000000</valUSD>
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        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

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            <shareNo>100.00000000</shareNo>
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            <delta>XXXX</delta>
            <unrealizedAppr>-17780.07</unrealizedAppr>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>MEDTRONIC PLC JAN20 113 CALL</title>
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        <balance>-47.00000000</balance>
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        <valUSD>-3572.00000000</valUSD>
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        <isRestrictedSec>N</isRestrictedSec>

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                <issuerName>Medtronic PLC</issuerName>
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            <shareNo>100.00000000</shareNo>
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      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>HUMANA INC JAN20 375 CALL</title>
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        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>JOHNSON + JOHNSON JAN20 135 CALL</title>
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            <shareNo>100.00000000</shareNo>
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            <unrealizedAppr>-112286.71</unrealizedAppr>
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      <invstOrSec>
        <name>NOMURA SECURITIES INTERNATIONAL INC</name>
        <lei>OXTKY6Q8X53C9ILVV871</lei>
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        <units>NC</units>
        <curCd>USD</curCd>
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        <pctVal>-0.00006588638</pctVal>
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        <assetCat>DE</assetCat>
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                <identifiers>
                  <isin value="CH0432492467"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>100.00000000</shareNo>
            <exercisePrice>60.35</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2020-01-17</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>20431.43</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>MIRATI THERAPEUTICS INC JAN20 105 CALL</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="BlackRock Identifier" value="Z947S6AB6"/>
        </identifiers>
        <balance>-36.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-90540.00000000</valUSD>
        <pctVal>-0.02028341688</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>Options Clearing Corp.</counterpartyName>
              <counterpartyLei>549300CII6SLYGKNHA04</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Mirati Therapeutics Inc</issuerName>
                <issueTitle>Mirati Therapeutics Inc</issueTitle>
                <identifiers>
                  <cusip value="60468T105"/>
                  <isin value="US60468T1051"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>100.00000000</shareNo>
            <exercisePrice>105</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2020-01-17</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-62963.18</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-01-29</ncom:dateSigned>
      <ncom:nameOfApplicant>BlackRock Health Sciences Trust</ncom:nameOfApplicant>
      <ncom:signature>Ann Frechette</ncom:signature>
      <ncom:signerName>Ann Frechette</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
