<SEC-DOCUMENT>0001437749-25-028477.txt : 20251205
<SEC-HEADER>0001437749-25-028477.hdr.sgml : 20251205
<ACCEPTANCE-DATETIME>20250905160715
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001437749-25-028477
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250905

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Monopar Therapeutics
		CENTRAL INDEX KEY:			0001645469
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				320463781
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		1000 SKOKIE BLVD SUITE 350
		CITY:			WILMETTE
		STATE:			IL
		ZIP:			60091
		BUSINESS PHONE:		8473880349

	MAIL ADDRESS:	
		STREET 1:		1000 SKOKIE BLVD SUITE 350
		CITY:			WILMETTE
		STATE:			IL
		ZIP:			60091
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Monopar Therapeutics Inc.</b><br>
1000 Skokie Blvd., Suite 350</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Wilmette, Illinois 60091</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">September 5, 2025</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b><u>VIA EDGAR</u></b></p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">U.S. Securities and Exchange Commission<br>
Division of Corporation Finance</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">100 F Street, N.E.<br>
Washington, D.C. 20549</p>

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			<p style="margin: 0pt; text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><b>Re:</b></p>
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			<p style="margin: 0pt; text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Monopar Therapeutics Inc.<br>
			Registration Statement on Form S-3<br>
			File No. 333-289947</p>
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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Ladies and Gentlemen:</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:36pt;">Pursuant to Rule 461 under the Securities Act of 1933, as amended (the &#8220;<u>Act</u>&#8221;), Monopar Therapeutics Inc. (the &#8220;<u>Company</u>&#8221;) hereby requests that the effective date of the above-referenced registration statement (the &#8220;<u>Registration Statement</u>&#8221;) be accelerated to September 9, 2025, at 5:00 p.m., Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Baker &amp; Hostetler LLP, request by telephone that such Registration Statement be declared effective at some other time. In making this acceleration request, the Company acknowledges that it is aware of its obligations under the Act.</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:36pt;">We request that we be notified of such effectiveness by a telephone call to John J. Harrington of Baker &amp; Hostetler LLP, counsel to the Company, at (216) 861-6697 and that such effectiveness also be confirmed in writing.</p>

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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Very truly yours,</p>

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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Monopar Therapeutics Inc.</p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;">Chandler D. Robinson</p>
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