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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2016

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of Stock Option Activity Under the 2012 and 2013 Plans

Stock option activity under the 2012 and 2013 plans is summarized as follows:

		Number of Options				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2015			1,229,339			$	7.32				9.0			$	(4,679	)
Granted			464,240				2.02
Exercised			(3,685	)			0.76
Cancelled			(112,878	)			4.97
Outstanding at December 31, 2016			1,577,016			$	5.95				8.4			$	71
Vested and expected to vest at December 31, 2016			1,492,341			$	5.97				8.4			$	69
Exercisable at December 31, 2016			561,693			$	6.79				7.8			$	52

Additional Information about Stock Option Activity

Additional information about the Company’s stock option activity is as follows:

		Year Ended December 31,
		2016				2015
Weighted-average grant date fair value per share of employee option grants within the year		$	1.26			$	4.08
Cash received upon exercise of options			3				39

Schedule of Restricted Stock Awards Under the 2012 and 2013 Plans

Restricted stock awards under the 2012 and 2013 plans are summarized as follows:

		Number of Shares				Weighted Average Grant Date Fair Value
Unvested at December 31, 2015			5,190			$	1.07
Vesting of restricted stock			(3,301	)
Unvested at December 31, 2016			1,889			$	0.83

Summary of Stock-Based Compensation

Stock-based compensation is as follows:

		Year Ended
		2016				2015
		(in thousands)
Research and development		$	491			$	451
General and administrative			1,057				777
Total stock-based compensation expense		$	1,548			$	1,228

Summary of Weighted-Average Assumptions Used in the Black-Scholes Option Pricing Model to Determine the Fair Value of the Employee Stock Option Grants

The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the employee stock option grants were as follows:

		Year Ended
		2016				2015
Risk-free interest rate			1.73	%			1.68	%
Expected volatility			72.5	%			62.6	%
Expected term (in years)			6.08				6.04
Expected dividend yield			0.0	%			0.0	%

Summary of Weighted-Average Assumptions Used in the Black-Scholes Option Pricing Model to Determine the Fair Value of the Non-Employee Stock Option Grants

The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the non-employee stock option grants were as follows:

		Year Ended
		2016				2015
Risk-free interest rate			1.57	%			1.79	%
Expected volatility			63.5	%			63.2	%
Expected term (in years)			7.00				6.16
Expected dividend yield			0.0	%			0.0	%

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Publisher FASB
-Name Accounting Standards Codification
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Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

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Tabular disclosure of the total intrinsic value of options exercised (or share units converted), share-based liabilities paid, and the total fair value of shares vested during the year.

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Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year.

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Tabular disclosure of each transaction in which an entity acquires goods or services other than employee services in exchange for equity securities of the company, including the purpose of the transaction, identification and quantity of the securities issued, the accounting made, disclosure of amounts by which report lines were affected, and noncash effects on the statement of cash flows.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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