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Commitments and Contingencies - Additional Information (Detail)
 1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2015
USD ($)
Jun. 30, 2012
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Options
Dec. 31, 2015
USD ($)
Loss Contingencies [Line Items]          
Rent expense under operating lease agreements       $ 1,000,000 $ 1,100,000
Research and development expense       $ 21,577,000 23,243,000
Waltham [Member]          
Loss Contingencies [Line Items]          
Number of additional renewal terms | Options       2  
Additional operating lease term       5 years  
Lexington [Member]          
Loss Contingencies [Line Items]          
Number of additional renewal terms | Options       1  
Additional operating lease term       5 years  
Hydrogel License Agreement [Member]          
Loss Contingencies [Line Items]          
Research and development expense       $ 3,200,000  
One-time payment amount     $ 3,000,000 3,000,000  
Tissue Regeneration License Agreement [Member]          
Loss Contingencies [Line Items]          
Research and development expense       700,000  
One-time payment amount     300,000 $ 300,000  
Percentage of royalty offsetting       50.00%  
Maximum [Member] | Waltham [Member]          
Loss Contingencies [Line Items]          
Construction allowance to total cost of tenant improvements       $ 3,200,000,000  
Maximum [Member] | Lexington [Member]          
Loss Contingencies [Line Items]          
Construction allowance to total cost of tenant improvements       1,000,000  
Minimum [Member] | Tissue Regeneration License Agreement [Member]          
Loss Contingencies [Line Items]          
Non-refundable royalty fee       10,000  
Tissue Processor Sub License Agreement [Member]          
Loss Contingencies [Line Items]          
Research and development expense       1,000,000  
Reimbursement for development cost   $ 300,000      
Potential milestone payments     10,200,000 10,200,000  
Additional non-refundable royalty fee       $ 30,000  
Additional non-refundable royalty fee payment description       2016 through 2019  
Tissue Processor Sub License Agreement [Member] | Minimum [Member]          
Loss Contingencies [Line Items]          
Non-refundable royalty fee       $ 20,000  
Engineering Agreement [Member]          
Loss Contingencies [Line Items]          
Amount paid to suppliers     200,000 600,000  
Additional payments due     0 $ 0  
Collagen Supply Agreement [Member]          
Loss Contingencies [Line Items]          
Minimum amount of material and/or services $ 200,000        
Non-refundable payment         $ 100,000
Initial term of the agreement 3 years        
Supplier agreement description       The initial term of the agreement is three years and will automatically renew from year to year thereafter unless otherwise terminated with at least 180 days' notice by either party.  
OCS Agreement [Member]          
Loss Contingencies [Line Items]          
Accrued and received grants, aggregate     $ 1,100,000 $ 1,100,000  
OCS Agreement [Member] | Maximum [Member]          
Loss Contingencies [Line Items]          
Royalties payment, rate       5.00%  
Royalty payment percentage as percentage of grant received       300.00%  
OCS Agreement [Member] | Minimum [Member]          
Loss Contingencies [Line Items]          
Royalties payment, rate       3.00%  
Royalty payment percentage as percentage of grant received       100.00%