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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (9,415) $ (14,833)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation 6 172
Loss on asset impairment 750  
Deferred rent and lease incentive   853
Stock-based compensation 107 403
Change in fair value of warrant liability 1,407 8,753
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 94 (664)
Other assets and accrued lease obligations, net (49) (375)
Accounts payable (491) 586
Accrued expenses (901) (1,609)
Deferred revenue   10,000
Net cash provided by (used in) operating activities (8,492) 3,286
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of property and equipment   (1,255)
Proceeds from maturities of marketable securities   900
Net cash used in investing activities   (355)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Repayments on equipment term loan   (133)
Net proceeds from issuance of common stock   5,732
Expenses incurred for at-the-market sales agreement of common stock   (106)
Proceeds from exercise of warrants 326  
Proceeds from exercise of stock options   2
Net cash provided by financing activities 326 5,495
Net increase (decrease) in cash and cash equivalents and restricted cash (8,166) 8,426
Cash and cash equivalents and restricted cash-Beginning of period 15,679 7,218
Cash and cash equivalents and restricted cash-End of period 7,513 15,644
Reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets:    
Cash and cash equivalents 7,376 15,507
Restricted cash 137 137
Total cash, cash equivalents, and restricted cash at the end of period 7,513 15,644
Supplemental cash flow disclosures from investing and financing activities:    
Right-of-use assets and lease liability recorded upon adoption of ASC 842 $ 6,635  
Purchases of property and equipment in accounts payable and accrued expenses   905
Public offering costs in accounts payable   $ 106