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License and Collaboration Agreements (Details) - USD ($) shares in Millions |  | 12 Months Ended
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Sep. 27, 2019 | Dec. 31, 2022 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2014
License agreements: |  |  |  |  |  |  |
Research and development |  |  | $ 8,085,522 | $ 10,321,397 |  |  |
Collaboration Agreement with CanSino Biologics |  |  |  |  |  |  |
License agreements: |  |  |  |  |  |  |
Term (in years) | 10 years |  |  |  |  |  |
Period within with Cansino to provide development cost statement | 45 days |  |  |  |  |  |
Period within which to reimburse Cansino of development costs | 1 year |  |  |  |  |  |
Schepens Eye Research Institute |  |  |  |  |  |  |
License agreements: |  |  |  |  |  |  |
License fee paid |  |  |  |  | $ 100,000 |  |
Potential development and regulatory milestone payments |  |  |  |  | 6,000,000.0 |  |
Potential commercial milestone payment |  |  |  |  | $ 10,100,000 |  |
Milestone payment |  |  | 0 |  |  |  |
Royalty payments |  |  | 0 |  |  |  |
Cancellation period, written notice |  |  |  |  | 180 days |  |
Research and development |  |  | 600,000 | 500,000 |  |  |
Collaboration agreement with University of Illinois, Chicago |  |  |  |  |  |  |
License agreements: |  |  |  |  |  |  |
Potential development and regulatory milestone payments |  |  |  |  |  | $ 1,300,000 |
Milestone payment |  |  |  | $ 300,000 |  |  |
Cancellation period, written notice |  |  |  | 90 days |  |  |
Signing fee paid |  |  |  |  |  | $ 15,000 |
Minimum annual royalty payment |  |  | $ 20,000 |  |  |  |
Collaboration agreement with University of Illinois, Chicago | Forecast |  |  |  |  |  |  |
License agreements: |  |  |  |  |  |  |
Minimum annual royalty payment |  | $ 50,000 |  |  |  |  |
Collaboration agreement with University of Colorado |  |  |  |  |  |  |
License agreements: |  |  |  |  |  |  |
Potential development and regulatory milestone payments |  |  |  |  | $ 1,500,000 |  |
Cancellation period, written notice |  |  |  |  |  |  | 60 days
Minimum annual royalty payment |  |  |  |  | $ 20,000 |  |
Shares issued (in shares) |  |  |  |  |  |  | 0.1

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- Definition Period within which the entity is to reimburse a party to collaboration agreement of development costs after a statement of such is provided upon termination of the agreement, , in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition Period within which a party to collaboration agreement is to provide the entity statement of development costs after termination of agreement, , in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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