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Nature of Business - Additional Information (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jul. 31, 2021 | Sep. 30, 2021 USD ($) | Jun. 30, 2021 USD ($) | Mar. 31, 2021 USD ($) | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Sep. 30, 2021 USD ($) geneticMutation product dose segment orphan_drug_designation | Sep. 30, 2020 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract] |  |  |  |  |  |  |  |  |  |  |
Number of operating segments | segment |  |  |  |  |  |  |  | 1 |  |  |
Number of vaccination dose regimen | dose |  |  |  |  |  |  |  | 2 |  |  |
Vaccination dose regimen, duration apart |  |  |  |  |  |  |  | 28 days |  |  |
Overall vaccine efficacy (percentage) | 77.80% |  |  |  |  |  |  |  |  |  |
Efficacy, severe cases (percentage) | 93.40% |  |  |  |  |  |  |  |  |  |
Efficacy, asymptomatic infection (percentage) | 63.60% |  |  |  |  |  |  |  |  |  |
Adverse events, side effects (percentage) | 12.40% |  |  |  |  |  |  |  |  |  |
Adverse events, serious adverse side effects (less than) (percentage) | 0.50% |  |  |  |  |  |  |  |  |  |
Efficacy against delta variant, B.1.617.2 (percentage) | 65.20% |  |  |  |  |  |  |  |  |  |
Single gene replacement therapies, number of genetic mutations target | geneticMutation |  |  |  |  |  |  |  | 1 |  |  |
Modifier gene therapy platform, number of products | product |  |  |  |  |  |  |  | 1 |  |  |
Number of ODDs received (orphan drug designation) | orphan_drug_designation |  |  |  |  |  |  |  | 4 |  |  |
Net loss |  | $ 10,755 | $ 25,952 | $ 7,077 | $ 10,474 | $ 3,614 | $ 3,944 | $ 43,784 | $ 18,032 |  |
Accumulated deficit |  | 117,086 |  |  |  |  |  | 117,086 |  | $ 73,302 |
Cash, cash equivalents and restricted cash |  | $ 107,500 |  |  | $ 19,257 |  |  | $ 107,500 | $ 19,257 | $ 24,190 | $ 7,595

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