<SEC-DOCUMENT>0001140361-20-011680.txt : 20200514
<SEC-HEADER>0001140361-20-011680.hdr.sgml : 20200514
<ACCEPTANCE-DATETIME>20200514205404
ACCESSION NUMBER:		0001140361-20-011680
CONFORMED SUBMISSION TYPE:	F-1MEF
PUBLIC DOCUMENT COUNT:		4
<REFERENCE-462B>333-237841
FILED AS OF DATE:		20200514
DATE AS OF CHANGE:		20200514
EFFECTIVENESS DATE:		20200514

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ADC Therapeutics SA
		CENTRAL INDEX KEY:			0001771910
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		F-1MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-238280
		FILM NUMBER:		20880154

	BUSINESS ADDRESS:	
		STREET 1:		BIOPOLE
		STREET 2:		ROUTE DE LA CORNICHE 3B
		CITY:			EPALINGES
		STATE:			V8
		ZIP:			1066
		BUSINESS PHONE:		41 21 653 02 00

	MAIL ADDRESS:	
		STREET 1:		BIOPOLE
		STREET 2:		ROUTE DE LA CORNICHE 3B
		CITY:			EPALINGES
		STATE:			V8
		ZIP:			1066
</SEC-HEADER>
<DOCUMENT>
<TYPE>F-1MEF
<SEQUENCE>1
<FILENAME>nt10009045x11_f1mef.htm
<DESCRIPTION>F-1MEF
<TEXT>
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  <div style="text-align: center;"><font style="font-weight: bold;">As filed with the Securities and Exchange Commission on May 14, 2020.</font>
    <div>
      <div>
        <div style="text-align: right; font-weight: bold;">Registration No. 333-&#160;&#160;&#160;&#160;&#160; <br>
        </div>
        <div style="text-align: right; font-weight: bold;">
          <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"> </div>
      </div>
      <div style="font-weight: bold;">UNITED STATES</div>
      <div style="font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="font-weight: bold;">Washington, D.C. 20549</div>
      <div>
        <hr style="height: 1px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
      <div style="font-weight: bold;">FORM F-1</div>
      <div style="font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="font-weight: bold;">UNDER</div>
      <div style="font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div>
        <hr style="height: 1px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
      <div style="font-weight: bold;">ADC THERAPEUTICS SA</div>
      <div>(Exact name of Registrant as specified in its charter)</div>
      <div style="font-weight: bold;">Not Applicable</div>
      <div>(Translation of Registrant&#8217;s name into English)</div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z02aec048d253428e9e7468c545539d97" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 33%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Switzerland</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">2834</div>
            </td>
            <td style="width: 33%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Not Applicable</div>
            </td>
          </tr>
          <tr>
            <td style="width: 33%; vertical-align: top;">
              <div style="text-align: center;">(State or other jurisdiction of</div>
              <div style="text-align: center;">incorporation or organization)</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center;">(Primary Standard Industrial</div>
              <div style="text-align: center;">Classification Code Number)</div>
            </td>
            <td style="width: 33%; vertical-align: top;">
              <div style="text-align: center;">(I.R.S. Employer</div>
              <div style="text-align: center;">Identification No.)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="font-weight: bold;">Biop&#244;le</div>
      <div style="font-weight: bold;">Route de la Corniche 3B</div>
      <div style="font-weight: bold;">1066 Epalinges</div>
      <div style="font-weight: bold;">Switzerland</div>
      <div style="font-weight: bold;">+41 21 653 02 00</div>
      <div>(Address, including zip code, and telephone number, including area code, of Registrant&#8217;s principal executive offices)</div>
      <div>
        <hr style="height: 1px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
      <div style="font-weight: bold;">ADC Therapeutics America, Inc.</div>
      <div style="font-weight: bold;">430 Mountain Avenue, 4th Floor</div>
      <div style="font-weight: bold;">Murray Hill, NJ 07974</div>
      <div style="font-weight: bold;">(908) 546-5556</div>
      <div>(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
      <div>
        <hr style="height: 1px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
      <div style="font-style: italic; font-weight: bold;">Copies to:</div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z6f2021d066424b0fb73c190f700e75fa" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 26.72%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Deanna L. Kirkpatrick</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Yasin Keshvargar</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Davis Polk &amp; Wardwell LLP</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">450 Lexington Avenue</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">New York, NY 10017</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(212) 450-4000</div>
            </td>
            <td style="width: 0.32%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.93%; vertical-align: middle;">&#160;</td>
            <td style="width: 21.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Dieter Gericke</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Benjamin Leisinger</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Homburger AG</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Hardstrasse 201</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CH-8005 Zurich,</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Switzerland</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">+41 43 222 10 00</div>
            </td>
            <td style="width: 1.09%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.09%; vertical-align: middle;">&#160;</td>
            <td style="width: 23.33%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Jacques Iffland</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Lenz &amp; Staehelin</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Route de Ch&#234;ne 30</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CH-1211 Geneva 6,</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Switzerland</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">+41 58 450 70 00</div>
            </td>
            <td style="width: 1.09%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.09%; vertical-align: middle;">&#160;</td>
            <td style="width: 23.33%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Divakar Gupta</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Richard C. Segal</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Alison A. Haggerty</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Cooley LLP</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">55 Hudson Yards</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">New York, NY 10001</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(212) 479-6000</div>
            </td>
          </tr>

      </table>
      <div>
        <hr style="height: 1px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
      <div style="text-align: left; text-indent: 18pt;"><font style="font-weight: bold;">Approximate date of commencement of proposed sale to the public: </font>As soon as practicable after the effective date of this registration statement.</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. &#8201;&#9744;</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement
        number of the earlier effective registration statement for the same offering. &#8201;&#9746; 333-237841</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier
        effective registration statement for the same offering. &#8201;&#9744;</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier
        effective registration statement for the same offering. &#8201;&#9744;</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933. Emerging growth company &#9746;</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for
        complying with any new or revised financial accounting standards&#8224; provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#8201;&#9744;</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">&#8224; The term &#8220;new or revised financial accounting standard&#8221; refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after April 5, 2012.</div>
      <div style="font-weight: bold;">
        <hr style="height: 1px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
      <div style="font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zf6d8c984da2b4ac2bcdcc02361779eb1" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 53.53%; vertical-align: bottom; border-top: #000000 4px double; border-bottom: #000000 2px solid;">
              <div style="text-align: center; font-weight: bold;">Title of each class of securities to be registered</div>
            </td>
            <td style="width: 0.53%; vertical-align: middle; border-right: #000000 2px solid; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 0.53%; vertical-align: middle; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 12.38%; vertical-align: bottom; border-top: #000000 4px double; border-bottom: #000000 2px solid;">
              <div style="text-align: center; font-weight: bold;">Amount to be</div>
              <div style="text-align: center; font-weight: bold;">&#160;registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)(2)</sup></div>
            </td>
            <td style="width: 0.53%; vertical-align: middle; border-right: #000000 2px solid; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 0.54%; vertical-align: middle; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 9.54%; vertical-align: bottom; border-top: #000000 4px double; border-bottom: #000000 2px solid;">
              <div style="text-align: center; font-weight: bold;">Proposed maximum</div>
              <div style="text-align: center; font-weight: bold;">&#160;aggregate offering price per unit</div>
            </td>
            <td style="width: 0.54%; vertical-align: middle; border-right: #000000 2px solid; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 0.54%; vertical-align: middle; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 9.54%; vertical-align: bottom; border-top: #000000 4px double; border-bottom: #000000 2px solid;">
              <div style="text-align: center; font-weight: bold;">Proposed maximum</div>
              <div style="text-align: center; font-weight: bold;">&#160;aggregate offering</div>
              <div style="text-align: center; font-weight: bold;">&#160;price</div>
            </td>
            <td style="width: 0.54%; vertical-align: middle; border-right: #000000 2px solid; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 0.54%; vertical-align: middle; border-top: #000000 4px double; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 10.68%; vertical-align: bottom; border-top: #000000 4px double; border-bottom: #000000 2px solid;">
              <div style="text-align: center; font-weight: bold;">Amount of registration fee<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
            </td>
          </tr>
          <tr>
            <td style="width: 53.53%; vertical-align: middle; border-bottom: #000000 4px double;">
              <div>Common shares, par value CHF 0.08 per share</div>
            </td>
            <td style="width: 0.53%; vertical-align: middle; border-right: #000000 2px solid; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 0.53%; vertical-align: middle; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 12.38%; vertical-align: middle; border-bottom: #000000 4px double;">
              <div style="text-align: center;">2,243,225<br>
              </div>
            </td>
            <td style="width: 0.53%; vertical-align: middle; border-right: #000000 2px solid; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 0.54%; vertical-align: middle; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 9.54%; vertical-align: middle; border-bottom: #000000 4px double;">
              <div style="text-align: center;">$19.00</div>
            </td>
            <td style="width: 0.54%; vertical-align: middle; border-right: #000000 2px solid; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 0.54%; vertical-align: middle; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 9.54%; vertical-align: middle; border-bottom: #000000 4px double;">
              <div style="text-align: center;">$42,621,275</div>
            </td>
            <td style="width: 0.54%; vertical-align: middle; border-right: #000000 2px solid; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 0.54%; vertical-align: middle; border-bottom: #000000 4px double;">&#160;</td>
            <td style="width: 10.68%; vertical-align: middle; border-bottom: #000000 4px double;">
              <div style="text-align: center;">$5,532.25</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z87d7ec61f1a147a884c0a0cda11b879b" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt; vertical-align: top; align: right;">(1)</td>
            <td style="width: auto; vertical-align: top;">
              <div>The common shares being registered in this Registration Statement are in addition to the 11,839,250 common shares registered pursuant to Registrant&#8217;s Registration Statement on Form F-1 (File No. 333-237841).</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z714f43290285470e92ec346a957a4013" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt; vertical-align: top; align: right;">(2)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Includes common shares granted pursuant to the underwriters&#8217; option to purchase additional common shares.</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze0f3c47126124c379dec7d8a16bb4935" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt; vertical-align: top; align: right;">(3)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Calculated pursuant to Rule 457(a) under the Securities Act of 1933, as amended, for the purpose of determining the registration fee. The Registrant previously registered securities with a proposed maximum aggregate offering price not to
                exceed $213,106,500 on the Registration Statement on Form F-1, as amended (File No. 333-237841), which was declared effective by the Securities and Exchange Commission on May 14, 2020. In accordance with Rule 462(b) under the Securities
                Act, an additional amount of securities having a proposed maximum aggregate offering price of $42,621,275 are hereby registered.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: left; font-weight: bold;">This Registration Statement shall become effective upon filing with the Securities and Exchange Commission in accordance with Rule 462(b) of the Securities Act.</div>
      <div>
        <div>
          <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;" align="center"></div>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div style="font-weight: bold;">EXPLANATORY NOTE AND INCORPORATION OF CERTAIN INFORMATION BY REFERENCE</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">This Registration Statement is being filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) pursuant to Rule 462(b) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;). This
        Registration Statement relates to the public offering of common shares, par value CHF 0.08 per share (the &#8220;Common Shares&#8221;), of ADC Therapeutics SA (the &#8220;Registrant&#8221;), contemplated by the Registration Statement on Form F-1, as amended (File No.
        333-237841), initially filed with the SEC by the Registrant on April 24, 2020 (as amended, the &#8220;Prior Registration Statement&#8221;) pursuant to the Securities Act, which was declared effective by the SEC on May 14, 2020. The contents of the Prior
        Registration Statement, including all amendments and exhibits thereto, are incorporated by reference into this Registration Statement.</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">The Registrant is filing this Registration Statement for the sole purpose of increasing the number of Common Shares to be registered for sale by 2,243,225 Common Shares. The additional Common Shares
        that are being registered for issuance and sale are in an amount and at a price that together represent no more than 20% of the maximum aggregate offering price set forth in the Calculation of Registration Fee table contained in the Prior
        Registration Statement. The information set forth in the Prior Registration Statement, and all exhibits to the Prior Registration Statement, are hereby incorporated by reference into this Registration Statement.</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">The required opinions and consents are listed on the Exhibit Index attached hereto and filed herewith.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
      </div>
      <div style="font-weight: bold;">EXHIBIT INDEX</div>
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 18pt;">The following documents are filed as part of this registration statement:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z6aec66f941e74ea2b1c85a116b423fbc" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div><a href="nt10009045x11_ex5-1.htm">5.1</a></div>
            </td>
            <td style="width: 1.96%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: bottom;">
              <div>Opinion of Homburger AG, Swiss counsel of ADC Therapeutics SA, as to the validity of the common shares</div>
            </td>
            <td style="width: 2.23%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: bottom;">
              <div><a href="nt10009045x11_ex23-1.htm">23.1</a></div>
            </td>
            <td style="width: 1.96%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: bottom;">
              <div>Consent of PricewaterhouseCoopers SA</div>
            </td>
            <td style="width: 2.23%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: bottom;">
              <div><a href="nt10009045x11_ex5-1.htm">23.2</a></div>
            </td>
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              <div>Consent of Homburger AG, Swiss counsel of ADC Therapeutics SA (included in Exhibit 5.1)</div>
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              <div><a href="http://www.sec.gov/Archives/edgar/data/1771910/000114036120009738/nt10009045x3_f1.htm#tSIGN">24.1**</a></div>
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              <div>Previously filed on the signature page to the Registrant&#8217;s Registration Statement on Form F-1, as amended (File No. 333-237841) filed with the Securities and Exchange Commission on May 24, 2020 and incorporated by reference herein.</div>
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      <div style="font-weight: bold;">SIGNATURES</div>
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      <div style="text-align: left; text-indent: 18pt;">Pursuant to the requirements of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
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              <div style="font-family: 'Times New Roman', Times, serif;">ADC THERAPEUTICS SA</div>
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            <td style="width: 47.6%; vertical-align: top;">&#160;</td>
            <td style="width: 3.75%; vertical-align: top;">&#160;</td>
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            <td style="width: 42%; vertical-align: top;">&#160;</td>
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              <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
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              <div style="font-family: 'Times New Roman', Times, serif;">/s/ Christopher Martin</div>
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      <div style="text-align: left; text-indent: 18pt;">Pursuant to the requirements of the Securities Act, this registration statement has been signed by the following persons on May 14, 2020 in the capacities indicated:</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Ron Squarer</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td rowspan="2" style="width: 55.29%; vertical-align: middle;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Peter B. Corr</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: top;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Stephen Evans-Freke</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td rowspan="2" style="width: 55.29%; vertical-align: middle;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Peter Hug</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td rowspan="2" style="width: 55.29%; vertical-align: middle;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Thomas Pfisterer</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Thomas M. Rinderknecht</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td rowspan="2" style="width: 55.29%; vertical-align: middle;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Tyrell J. Rivers</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td rowspan="2" style="width: 55.29%; vertical-align: middle;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Director</div>
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            <td style="width: 41.01%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Victor Sandor</div>
            </td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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          <tr>
            <td style="border-bottom: 1px solid #000000; vertical-align: top; width: 41.01%;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">*</div>
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            <td style="width: 3.69%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Jacques Theurillat</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
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            <td style="width: 41.01%; vertical-align: top;">&#160;</td>
            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: middle;">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Jay Feingold</div>
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              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">ADC Therapeutics America, Inc.</div>
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            <td style="width: 3.69%; vertical-align: top;">&#160;</td>
            <td style="width: 55.29%; vertical-align: top;">&#160;</td>
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            <td style="width: 8.76%; vertical-align: top;">&#160;</td>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>nt10009045x11_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 5.1</font><br>
    </div>
    <div> <br>
    </div>
    <div style="text-align: right;"> <img src="nt10009045x11_ex5-1image01.jpg">
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            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">ADC Therapeutics SA</div>
                <div style="font-family: 'Times New Roman', Times, serif;"><font style="background-color: #FFFFFF;">Biop&#244;le</font></div>
                <div style="font-family: 'Times New Roman', Times, serif;"><font style="background-color: #FFFFFF;">Route de la Corniche 3 B</font></div>
                <div style="font-family: 'Times New Roman', Times, serif;"><font style="background-color: #FFFFFF;">1066 Epalinges</font></div>
                <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;"><font style="background-color: #FFFFFF;">Switzerland</font></div>
              </td>
              <td style="width: 50.01%; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Homburger AG</div>
                <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Prime Tower</div>
                <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Hardstrasse 201 | CH&#8211;8005 Zurich</div>
                <div>&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">T&#160; +41 43 222 10 00</div>
                <div style="font-family: 'Times New Roman', Times, serif;">F&#160; +41 43 222 15 00</div>
                <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">lawyers@homburger.ch</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-weight: normal;">May 14, 2020</font></div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif; font-weight: bold;">ADC Therapeutics SA &#8211; Registration Statement on Form F-1</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Ladies and Gentlemen</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">We have acted as special Swiss counsel to ADC Therapeutics SA, a stock corporation incorporated under the laws of Switzerland (the<font style="font-weight: bold;">
          Company</font>), in connection with the filing of a registration statement on Form F-1, including the prospectus set forth therein (the <font style="font-weight: bold;">Registration Statement</font>), to be filed with the United States
        Securities and Exchange Commission (the <font style="font-weight: bold;">SEC</font>) on the date hereof for the purpose of registering under the United States Securities Act of 1933, as amended (the <font style="font-weight: bold;">Securities Act</font>),





        the offer and sale of up to 14,082,475 common shares of the Company, each with a nominal value of CHF 0.08 (the <font style="font-weight: bold;">Common Shares</font>), including any common shares with a nominal value of CHF 0.08 each to be sold,
        if and to the extent such option is exercised, to the underwriters pursuant to the over-allotment option granted by the Company to the underwriters. As such counsel, we have been requested to give our opinion as to certain legal matters of Swiss
        law.</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Capitalized terms used but not defined herein shall have the meaning ascribed to them in the Documents (as defined below).</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zaad559385765475399d66c5145615694" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 0pt;"><br>
            </td>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">I.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Basis of Opinion</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">This opinion is confined to and given on the basis of the laws of Switzerland in force at the date hereof. Such laws and the interpretation thereof are subject to change.
        In the absence of explicit statutory law, we base our opinion solely on our independent professional judgment. This opinion is also confined to the matters stated herein and is not to be read as extending, by implication or otherwise, to any
        document referred to in the Documents (other than listed below) or any other matter.</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">For purposes of this opinion we have not conducted any due diligence or similar investigation as to factual circumstances, which are or may be referred to in the
        Documents, and we express no opinion as to the accuracy of representations and warranties of facts set out in the Documents or the factual background assumed therein.</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">For purposes of this opinion, we have only reviewed originals or copies of the following documents we have deemed necessary or advisable for the purpose of rendering this
        opinion (collectively the <font style="font-weight: bold;">Documents</font>):</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8a5601c1902548df9fc75e4cf36a540b" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(i)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">an electronic copy of the Registration Statement; <br>
              </div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div>
        <table class="DSPFListTable" id="zb0244a3423594880b5bddb4a12a1ca73" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 28.35pt;">
                <div>(ii)</div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div>an electronic copy of the notarized shareholders&#8217; resolutions passed at the Company&#8217;s extraordinary general meeting held on April 24, 2020 (the <font style="font-weight: bold;">Shareholders&#8217; Resolutions</font>); and</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6da4317ad0f64c4eb89a435a6637daa7" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(iii)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">an electronic copy of the articles of association (<font style="font-style: italic;">statuts</font>) of the Company, the form of which is filed as Exhibit 3.1 to the Registration
                Statement (the <font style="font-weight: bold;">Articles of Association</font>).</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">No documents, other than the Documents, have been reviewed by us in connection with this opinion. Accordingly, we shall limit our opinion to the Documents and their legal
        implications under Swiss law.</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">In this opinion, Swiss legal concepts are expressed in English terms and not in their original language. These concepts may not be identical to the concepts described by
        the same English terms as they exist under the laws of other jurisdictions.</div>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div style="text-align: right;"><font style="font-family: Arial; font-size: 8pt;">2 | 4</font><br>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z054272574757479bbf3a9ea623c3b7ad" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 0pt;"><br>
            </td>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">II.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Assumptions</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">In rendering the opinion below, we have assumed the following:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd054e617c28f48fabae6d72d0b98f511" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(a)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">all documents produced to us as originals are authentic and complete, and all documents produced to us as copies (including, without limitation, electronic copies) conform to the
                original;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3da19aba0427467e87678f4877b4afe5" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(b)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">all documents produced to us as originals and the originals of all documents produced to us as copies were duly executed and certified, as applicable, by the individuals purported to
                have executed or certified, as the case may be, such documents;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zef756d8d98774e68a4141f573cb11a1b" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(c)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">all documents produced to us in draft form will be executed in the form of the draft submitted to us;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za01339ffdc5140ffba80df4418ff84bf" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(d)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">each party to the Documents is a corporation or other legal entity duly organized and validly existing and in good standing (if applicable) under the laws of the jurisdiction of its
                incorporation and|or establishment and none of the parties to the Documents (other than the Company) has passed or, until the issuance of all Common Shares, will have passed a voluntary winding-up resolution; no petition has been, or, until
                the issuance of all Common Shares, will be presented or order made by a court for the winding-up, dissolution, bankruptcy or administration of any party (other than the Company); and no receiver, trustee in bankruptcy, administrator or
                similar officer has been or, until the issuance of all Common Shares, will have been appointed in relation to any of the parties (other than the Company) or any of their assets or revenues;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z64572f4c38824d6ebf5c34d684162ade" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(e)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">to the extent relevant for purposes of this opinion, any and all information contained in the Docu-ments is and will be true, complete and accurate at all relevant times;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0112ff73234d4169b325b34b3bb3bc2d" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(f)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">no laws (other than those of Switzerland) affect any of the conclusions stated in this opinion;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3e13b9347b93491ebce7521c1d09f295" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(g)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">the Registration Statement is unchanged and correct, complete and up-to-date and in full force and effect as of the date hereof and no changes have been made which should have been or
                should be reflected in the Registration Statement as of the date hereof;</div>
            </td>
          </tr>

      </table>
      <br>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z89230d90d101420da34ba5643f977ad1" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(h)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">The Shareholders' Resolutions (i) have been duly resolved in a meeting duly convened and otherwise in the manner set forth therein, (ii)&#160; have not been amended and (iii) are&#160; in full
                force and effect;</div>
            </td>
          </tr>

      </table>
      <br>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z74e3b18cc34b423782f25e7dc7986d3c" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(i)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">prior to the issuance of any Common Shares, the board of directors of the Company will have duly authorized the issuance and sale of such Common Shares and will have validly excluded
                the pre-emptive rights of the existing shareholders for purposes of offering and selling the Common Shares as contemplated in the Registration Statement, and such authorization will not have been amended and will be in full force and effect
                until the issuance of all Common Shares;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf4649b62b5044e8993a7ec5fbcd77dea" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(j)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">the Company has not entered and will not enter into any transaction which could be construed as repayment of share capital (<font style="font-style: italic;">r&#233;stitution des
                  versements</font>) and has not undertaken and will not undertake an acquisition in kind (<font style="font-style: italic;">reprise des biens</font>) or intended acquisition in kind (<font style="font-style: italic;">reprise des biens
                  envisag&#233;e</font>) without complying with the formal procedure set forth in article 628 of the Swiss Code of Obligations; and</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div>
        <div style="text-align: right;"><font style="font-family: Arial; font-size: 8pt;">3 | 4</font><br>
        </div>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf901760b6da645a58b0227d6848d878c" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(k)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">all authorizations, approvals, consents, licenses, exemptions, other than as required by mandatory Swiss law applicable to the Company or the Articles of Association, and other
                requirements for the filing of the Registration Statement or for any other activities carried on in view of, or in connection with, the performance of the obligations expressed to be undertaken by the Company in the Registration Statement
                have been duly obtained or fulfilled in due time and are and will remain in full force and effect, and any related conditions to which the parties thereto are subject have been satisfied.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z02fa3a3776c84f2498433066afb92484" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 0pt;"><br>
            </td>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">III.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Opinion</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Based on the foregoing and subject to the qualifications set out below, we are of the opinion that <font style="background-color: #FFFFFF;">the Common Shares, when
          issued and paid for pursuant to the Articles of Association and Swiss law, in particular upon registration of the corresponding share capital increase into the Commercial Register of the Canton of Vaud, and entered into the Company&#8217;s book of
          uncertificated securities, will be </font>validly issued, fully paid as to their nominal value and non-assessable.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z47bd2d750ad544fbb99184afb0cad044" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 0pt;"><br>
            </td>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">IV.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Qualifications</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: -28.4pt; margin-left: 28.4pt; font-family: 'Times New Roman', Times, serif;">The above opinions are subject to the following qualifications:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd15c00650ece46119a8f0dae634d491e" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(a)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">The lawyers of our firm are members of the Zurich bar and do not hold themselves out to be experts in any laws other than the laws of Switzerland. Accordingly, we are opining herein
                as to Swiss law only and we express no opinion with respect to the applicability or the effect of the laws of any other jurisdiction to or on the matters covered herein.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z37efbed52a134be3b335ec2164dfbb10" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(b)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">The exercise of voting rights and rights related thereto with respect to any Common Shares is only permissible after registration in the Company&#8217;s share register as a shareholder with
                voting rights in accordance with the provisions of, and subject to the limitations provided in, the Articles of Association.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zceb921cf31574aaf8a088019f5f8507f" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(c)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">We express no opinion as to whether the Registration Statement is accurate, true, correct, complete or not misleading. In particular, and without limitation to the foregoing, we
                express no opinion on whether the Registration Statement provides sufficient information for investors to reach an informed assessment of the Company, any companies within the Company&#8217;s consolidation perimeter and the Common Shares.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4390830668bc45a293fdde8d28a5116e" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(d)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">Notwithstanding or irrespective of registration of the capital increase with the Commercial Register of the Canton of Vaud, the underlying shareholders&#8217; resolutions may be challenged
                by a dissenting shareholder of the Company or others in court or otherwise. However, we believe that a challenge of the underlying shareholders&#8217; resolution by a dissenting shareholder of the Company after registration of the Common Shares
                with the Commercial Register of the Canton of Vaud, even if successful, would not in itself void such Common Shares.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z223fdf3d7c97462e93edb274a5c5a721" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 28.35pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif;">(e)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman', Times, serif;">We express no opinion as to regulatory matters or as to any commercial, accounting, calculating, auditing or other non-legal matter.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">We have issued this opinion as of the date hereof and we assume no obligation to advise you of any changes in fact or in law that are made or brought to our attention
        hereafter.</div>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div>
        <div style="text-align: right;"><font style="font-family: Arial; font-size: 8pt;">4 | 4</font><br>
        </div>
        <div><br>
        </div>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">We hereby consent to the filing of this opinion as an exhibit to the Registration Statement and further consent to the reference to our name under the caption &#8220;Legal
        Matters&#8221; in the Prospectus. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.</div>
      <div><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">This opinion is governed by and shall be construed in accordance with the laws of Switzerland.</div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif;">Sincerely yours</div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif;">Homburger AG</div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif;">/s/ Benjamin Leisinger</div>
      <div style="font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif;">
        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
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      </div>
      <div><br>
      </div>
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<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>nt10009045x11_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
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      <div style="background-color: #FFFFFF;">
        <div style="text-align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Exhibit 23.1</div>
      </div>
      <div style="background-color: #FFFFFF;">
        <div><font style="font-family: 'Times New Roman',Times,serif;">&#160;<br>
          </font> </div>
        <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Consent of Independent Registered Public Accounting Firm</div>
        <div><font style="font-family: 'Times New Roman',Times,serif;">&#160;<br>
          </font> </div>
      </div>
      <div style="background-color: #FFFFFF;">
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          <div>
            <div>We hereby consent to the incorporation by reference in this Registration Statement on Form F-1 of our report dated March 2, 2020, except for the
              effects of the share consolidation discussed in Note 2 (v) to the consolidated financial statements, as to which the date is April 24, 2020 relating to the consolidated financial statements, which appears in Amendment No. 3 to the
              Registration Statement on Form F-1 (No. 333-237841) of ADC Therapeutics SA. We also consent to the reference to us under the heading &#8220;Experts&#8221; in Amendment No. 3 to the Registration Statement on Form F-1 (No. 333-237841) incorporated by
              reference in this Registration Statement.</div>
          </div>
        </div>
        <div><font style="font-family: 'Times New Roman',Times,serif;">&#160;<br>
          </font> </div>
        <div style="font-family: 'Times New Roman', Times, serif;">/s/ PricewaterhouseCoopers SA<br>
          Lausanne, Switzerland<br>
          May 14, 2020</div>
        <div style="font-family: 'Times New Roman', Times, serif;"> <font style="font-family: 'Times New Roman',Times,serif;"><br>
          </font> </div>
        <div style="font-family: 'Times New Roman', Times, serif;">
          <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
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