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Operating expense - Schedule of Expenses by Nature (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Disclosure Of Detailed Information About Expenses By Nature [Line Items] |  |  |  |
Cost of product sales | $ 1,295 | $ 502 | $ 4,090 | $ 623
Research and development expense | 41,676 | 36,805 | 139,165 | 115,510
Sales and marketing expense | 16,847 | 17,045 | 52,876 | 46,177
General and administrative expense | 19,617 | 16,587 | 56,868 | 53,536
Operating expense | 79,435 | 70,939 | 252,999 | 215,846
External costs |  |  |  |
Disclosure Of Detailed Information About Expenses By Nature [Line Items] |  |  |  |
Research and development expense | 24,363 | 20,041 | 83,706 | 66,330
Sales and marketing expense | 8,236 | 7,973 | 26,406 | 18,989
General and administrative expense | 5,020 | 4,599 | 18,539 | 15,204
Employee expense |  |  |  |
Disclosure Of Detailed Information About Expenses By Nature [Line Items] |  |  |  |
Research and development expense | 17,313 | 16,764 | 55,459 | 49,180
Sales and marketing expense | 8,611 | 9,072 | 26,470 | 27,188
General and administrative expense | $ 14,597 | $ 11,988 | $ 38,329 | $ 38,332

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- Definition The amount of all expenses directly or indirectly attributed to the goods or services sold. Attributed expenses include, but are not limited to, costs previously included in the measurement of inventory that has now been sold, such as depreciation and maintenance of factory buildings and equipment used in the production process, unallocated production overheads, and abnormal amounts of production costs of inventories. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Name IAS -Number 1 -IssueDate 2022-03-24 -Paragraph 99 -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=1&code=ifrs-tx-2022-en-r&anchor=para_99&doctype=Standard -URIDate 2022-03-24 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Name IAS -Number 1 -IssueDate 2022-03-24 -Paragraph 103 -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=1&code=ifrs-tx-2022-en-r&anchor=para_103&doctype=Standard -URIDate 2022-03-24 + Details
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- Definition The amount of expense relating to general and administrative activities of the entity. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Name IAS -Number 1 -IssueDate 2022-03-24 -Paragraph 112 -Subparagraph c -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=1&code=ifrs-tx-2022-en-r&anchor=para_112_c&doctype=Standard -URIDate 2022-03-24 + Details
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- Definition The amount of expenditure directly attributable to research or development activities, recognised in profit or loss. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Name IAS -Number 38 -IssueDate 2022-03-24 -Paragraph 126 -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=38&code=ifrs-tx-2022-en-r&anchor=para_126&doctype=Standard -URIDate 2022-03-24 + Details
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- Definition The amount of expense relating to the marketing and selling of goods or services. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Name IAS -Number 1 -IssueDate 2022-03-24 -Paragraph 85 -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=1&code=ifrs-tx-2022-en-r&anchor=para_85&doctype=Standard -URIDate 2022-03-24 + Details
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