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Convertible loans - Change in Fair Value (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
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Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Disclosure of detailed information about borrowings [line items] |  |  |  |
Gains (losses) on change in fair value of derivatives | $ (4,660) | $ (6,943) | $ 25,650 | $ 16,279
Facility Agreement With Deerfield Partners, L.P., Tranche One |  |  |  |
Disclosure of detailed information about borrowings [line items] |  |  |  |
Gains (losses) on change in fair value of derivatives | (2,822) | (3,913) | 15,556 | 16,867
Facility Agreement With Deerfield Partners, L.P., Tranche Two Prior to FDA Approval |  |  |  |
Disclosure of detailed information about borrowings [line items] |  |  |  |
Gains (losses) on change in fair value of derivatives | 0 | 0 | 0 | 3,454
Facility Agreement With Deerfield Partners, L.P., Tranche Two After FDA Approval |  |  |  |
Disclosure of detailed information about borrowings [line items] |  |  |  |
Gains (losses) on change in fair value of derivatives | $ (1,838) | $ (3,030) | $ 10,094 | $ (4,042)

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