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Segment reporting | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment reporting | Segment reporting The Company is managed and operated as one reportable segment, which includes all global activities related to the development and commercialization of targeted ADC cancer therapies. The determination of a single reportable segment is consistent with the consolidated financial information regularly provided to the Company’s CODM, which is its chief executive officer. The CODM uses loss from operations and consolidated net loss for purposes of assessing performance, making operating decisions, allocating resources and planning and forecasting for future periods. The CODM allocates resources and plans for the long-term growth of the Company based on the Company's available cash resources, forecasted cash flow, and expenditures on a consolidated basis, as well as an assessment of the probability of success of its research and development activities. Resource allocation and long-term growth decisions are informed by budgeted and forecasted expense information, along with actual expenses incurred to date. The measure of segment assets is reported on the consolidated balance sheets as total assets. The following table is the summary of the segment profit or loss information, including the significant expense categories for the three and nine months ended September 30, 2025 and 2024, respectively:
|  | Three Months Ended September 30, |  | Nine Months Ended September 30,
|  | 2025 |  | 2024 |  | 2025 |  | 2024
Total revenues, net |  | $ | 16,427 |  |  | $ | 18,464 |  |  | $ | 58,299 |  |  | $ | 53,927 |
Significant operating expenses: |  |  |  |  |  |  |  |
Cost of product sales |  | (1,202) |  |  | (851) |  |  | (4,099) |  |  | (4,578) |
Research and development(1) |  | (26,293) |  |  | (31,511) |  |  | (83,833) |  |  | (81,683) |
Selling and marketing(1) |  | (10,345) |  |  | (10,318) |  |  | (30,422) |  |  | (32,852) |
General and administrative(1) |  | (7,180) |  |  | (8,542) |  |  | (23,575) |  |  | (28,080) |
Restructuring and impairment expenses |  | (377) |  |  | — |  |  | (13,468) |  |  | — |
Share-based compensation |  | (1,999) |  |  | (2,806) |  |  | (6,482) |  |  | (4,952) |
Total operating expenses |  | (47,396) |  |  | (54,028) |  |  | (161,879) |  |  | (152,145) |
Loss from operations |  | (30,969) |  |  | (35,564) |  |  | (103,580) |  |  | (98,218) |
Other segment items(2) |  | (9,997) |  |  | (8,405) |  |  | (32,634) |  |  | (28,901) |
Net loss |  | $ | (40,966) |  |  | $ | (43,969) |  |  | $ | (136,214) |  |  | $ | (127,119) |
(1)Excludes share-based compensation. (2)Includes Other expense, net, Income tax expense and Equity in net losses of joint venture.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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