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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Cash flows used in operating activities |  |
Net loss | $ (136,214) | $ (127,119)
Adjustments to reconcile net loss to net cash used in operations: |  |
Share-based compensation expense | 6,232 | 4,952
Accretion expense of deferred royalty obligation | 21,348 | 20,964
Cumulative catch-up adjustment, deferred royalty obligation | (517) | (732)
Impairment of long-lived assets and prepaid expenses, and other related costs | 7,240 | 0
Write-downs of inventory | 1,873 | 1,036
Depreciation | 705 | 993
Amortization of operating lease right-of-use assets | 1,058 | 1,490
Share of results in joint venture | 0 | 1,544
Amortization of debt discount, senior secured term loan | 1,574 | 1,459
Other | 426 | (369)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (2,602) | 1,058
Inventory | (1,528) | (930)
Prepaid expenses and other current assets | 5,448 | (2,055)
Other long-term assets | (46) | (457)
Accounts payable | (9,970) | (1,217)
Accrued expenses and other current liabilities | (9,394) | (165)
Operating lease liabilities | (1,994) | (1,499)
Other long-term liabilities | 6,310 | (936)
Net cash used in operating activities | (110,051) | (101,983)
Cash flows used in investing activities |  |
Payment for purchases of property and equipment | (264) | (777)
Net cash used in investing activities | (264) | (777)
Cash flows provided by financing activities |  |
Proceeds from the sale of common shares, net of transaction costs | 42,760 | 60,506
Proceeds from Pre-Funded Warrants, net of transaction costs | 50,760 | 36,925
Proceeds from share issuance under stock purchase plan | 271 | 558
Proceeds from the exercise of stock options | 315 | 185
Taxes paid related to net settled equity awards | (250) | 0
Net cash provided by financing activities | 93,856 | 98,174
Net decrease in cash and cash equivalents | (16,459) | (4,586)
Exchange gains on cash and cash equivalents | 330 | 260
Cash and cash equivalents at beginning of period | 250,867 | 278,598
Cash and cash equivalents at end of period | 234,738 | 274,272
Supplemental Cash Flow Information: |  |
Interest paid | 10,882 | 11,942
Interest received | 6,458 | 11,074
Payments made under royalty financing transaction | 4,816 | 3,927
Supplemental Non-Cash Investing and Financing Activities: |  |
Transaction costs recorded in Accounts payable and other current liabilities and Other long-term liabilities | 384 | 0
Capital expenditures recorded in Accounts payable and other current liabilities | $ 0 | $ 38

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