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Property and equipment
 9 Months Ended
Sep. 30, 2025
Property, Plant and Equipment [Abstract]  
Property and equipment Property and equipment
Property and equipment as of September 30, 2025 and December 31, 2024 consisted of the following:
(in thousands)September 30, 2025December 31, 2024
Leasehold improvements
$1,472 $3,873 
Laboratory equipment2,949 4,415 
Office equipment770 970 
Hardware and computer software
1,144 1,137 
6,335 10,395 
Less: accumulated depreciation(6,335)(5,320)
Property and equipment, net$— $5,075 

Depreciation expense was nil and $705 for the three and nine months ended September 30, 2025, respectively, and $336 and $993 for the three and nine months ended September 30, 2024, respectively.

In connection with the 2025 Restructuring, the Company recorded impairment of property and equipment of $5.0 million during the second quarter of 2025,related to leasehold improvements, lab equipment and furniture and fixtures located at the UK facility. See Note 15 for further information regarding the restructuring and associated
impairment of long-lived assets. There were no impairments of property and equipment recorded during the three and nine months ended September 30, 2024.