XML 19 R7.htm IDEA: XBRL DOCUMENT v3.25.3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Cash flows used in operating activities    
Net loss $ (136,214) $ (127,119)
Adjustments to reconcile net loss to net cash used in operations:    
Share-based compensation expense 6,232 4,952
Accretion expense of deferred royalty obligation 21,348 20,964
Cumulative catch-up adjustment, deferred royalty obligation (517) (732)
Impairment of long-lived assets and prepaid expenses, and other related costs 7,240 0
Write-downs of inventory 1,873 1,036
Depreciation 705 993
Amortization of operating lease right-of-use assets 1,058 1,490
Share of results in joint venture 0 1,544
Amortization of debt discount, senior secured term loan 1,574 1,459
Other 426 (369)
Changes in operating assets and liabilities:    
Accounts receivable, net (2,602) 1,058
Inventory (1,528) (930)
Prepaid expenses and other current assets 5,448 (2,055)
Other long-term assets (46) (457)
Accounts payable (9,970) (1,217)
Accrued expenses and other current liabilities (9,394) (165)
Operating lease liabilities (1,994) (1,499)
Other long-term liabilities 6,310 (936)
Net cash used in operating activities (110,051) (101,983)
Cash flows used in investing activities    
Payment for purchases of property and equipment (264) (777)
Net cash used in investing activities (264) (777)
Cash flows provided by financing activities    
Proceeds from the sale of common shares, net of transaction costs 42,760 60,506
Proceeds from Pre-Funded Warrants, net of transaction costs 50,760 36,925
Proceeds from share issuance under stock purchase plan 271 558
Proceeds from the exercise of stock options 315 185
Taxes paid related to net settled equity awards (250) 0
Net cash provided by financing activities 93,856 98,174
Net decrease in cash and cash equivalents (16,459) (4,586)
Exchange gains on cash and cash equivalents 330 260
Cash and cash equivalents at beginning of period 250,867 278,598
Cash and cash equivalents at end of period 234,738 274,272
Supplemental Cash Flow Information:    
Interest paid 10,882 11,942
Interest received 6,458 11,074
Payments made under royalty financing transaction 4,816 3,927
Supplemental Non-Cash Investing and Financing Activities:    
Transaction costs recorded in Accounts payable and other current liabilities and Other long-term liabilities 384 0
Capital expenditures recorded in Accounts payable and other current liabilities $ 0 $ 38