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Segment reporting - Schedule of Segment Reporting Information, by Segment (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Segment Reporting Information [Line Items]        
Total revenues, net $ 16,427 $ 18,464 $ 58,299 $ 53,927
Restructuring and impairment expenses (377) 0 (13,468) 0
Total operating expense (47,396) (54,028) (161,879) (152,145)
Loss from operations (30,969) (35,564) (103,580) (98,218)
Net loss (40,966) (43,969) (136,214) (127,119)
Reportable Segment        
Segment Reporting Information [Line Items]        
Total revenues, net 16,427 18,464 58,299 53,927
Cost of product sales (1,202) (851) (4,099) (4,578)
Research and development (26,293) (31,511) (83,833) (81,683)
Selling and marketing (10,345) (10,318) (30,422) (32,852)
General and administrative (7,180) (8,542) (23,575) (28,080)
Restructuring and impairment expenses (377) 0 (13,468) 0
Share-based compensation (1,999) (2,806) (6,482) (4,952)
Total operating expense (47,396) (54,028) (161,879) (152,145)
Loss from operations (30,969) (35,564) (103,580) (98,218)
Other segment items (9,997) (8,405) (32,634) (28,901)
Net loss $ (40,966) $ (43,969) $ (136,214) $ (127,119)