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v3.26.1

Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2026 | Jun. 30, 2025
Cash flows from operating activities: |  |
Net loss | $ (87,900) | $ 34,590
Adjustments to reconcile net loss to net cash used in operating activities |  |
Stock-based compensation expense | 11,919 | 10,192
Depreciation | 3,943 | 4,173
Net accretion of discounts/premiums on marketable securities | (1,960) | (1,766)
Gain on disposal of property and equipment | 0 | (59)
Changes in operating assets and liabilities |  |
Collaboration receivable | 7,000 | 0
Other receivables | (320) | (2,196)
Prepaid expenses and other assets | (1,581) | (1,713)
Accounts payable | 2,884 | (11,976)
Accrued expenses and other current liabilities | (1,502) | (5,077)
Defined benefit plan liability | 85 | 957
Right-of-use assets and operating lease liabilities | (874) | (427)
Deferred revenue | (13,177) | (106,910)
Net cash used in operating activities | (81,483) | (80,212)
Cash flows from investing activities: |  |
Purchases of property and equipment | (6,591) | (3,282)
Purchases of marketable securities | (408,071) | (157,047)
Proceeds from maturities of marketable securities | 124,805 | 85,424
Net cash used in investing activities | (289,857) | (74,905)
Cash flows from financing activities: |  |
Proceeds from exercise of employee stock options | 7,122 | 14
Proceeds from underwritten public offering, net of underwriter's commission of $20,700 | 324,300 | 0
Payment of offering costs | (487) | 0
Proceeds from employee stock purchase plan | 611 | 365
Net cash provided by financing activities | 331,546 | 379
Net decrease in cash, cash equivalents and restricted cash | (39,794) | (154,738)
Cash, cash equivalents and restricted cash—beginning of period | 134,837 | 229,117
Cash, cash equivalents and restricted cash-end of period | 95,043 | 74,379
Reconciliation of cash, cash equivalents and restricted cash |  |
Cash and cash equivalents | 90,104 | 69,429
Restricted cash | 4,939 | 4,950
Total cash, cash equivalents and restricted cash | 95,043 | 74,379
Supplemental disclosure of noncash items |  |
Purchases of property and equipment in accounts payable and accrued expenses | $ 1,450 | $ 450

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